Immunology & Inflammation

50 个项目

每页

设置降序顺序
  1. MK-0679 (Verlukast)

    Catalog No. A11607
    LTD4 receptor 拮抗剂
    MK-0679 (Verlukast)是有效的白三烯D4拮抗剂。 了解更多
  2. LY 255283

    Catalog No. A13090
    Quick View
    BLT2 receptors 拮抗剂
    LY 255283是一种有效的 BLT2 receptors 拮抗剂。 了解更多
  3. MK-571

    Catalog No. A12529
    Quick View
    CysLT1 receptor 拮抗剂
    MK-571是有效的CysLT1(LTD4)白三烯受体反向激动剂,EC50值为1.3 nM。 了解更多
  4. MK-571 sodium salt

    Catalog No. A15983
    Quick View
    CysLT1 receptor 拮抗剂
    MK-571 sodium salt是一种选择性的口服活性CysLT1受体拮抗剂。它阻断LTD4而不是LTC4与人和豚鼠肺膜的结合,Ki值分别为0.22 nM和2.1 nM。 了解更多
  5. Montelukast

    Catalog No. A17780
    Quick View
    LTR antagonist
    Montelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. 了解更多
  6. AS-35

    Catalog No. A19409
    Quick View
    LTR antagonist
    AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. 了解更多
  7. Plerixafor 8HCl (DB06809)

    Catalog No. A10913
    Quick View
    CXCR4 拮抗剂
    Plerixafor 8HCl (DB06809)是CXCR4趋化因子受体拮抗剂,作用于CXCR4和CXCL12介导调节的趋化性, IC50分别为44 nM和5.7 nM。 了解更多
  8. AMD 070

    Catalog No. A11315
    Quick View
    CXCR4 拮抗剂
    AMD 070是CXCR4趋化因子受体拮抗剂。 了解更多
  9. AMD 3465 Hexahydrobromide

    Catalog No. A11953
    Quick View
    CXCR4 拮抗剂
    AMD 3465 Hexahydrobromide是一种有效的选择性CXCR4拮抗剂。 了解更多
  10. WZ811

    Catalog No. A12588
    Quick View
    CXCR4 拮抗剂
    WZ811是4型C-X-C趋化因子受体(CXCR4)拮抗剂(EC50 = 0.3 nM)。在体外抑制CXCR4/基质细胞衍生因子1(SDF-1)介导的cAMP调节(EC50 = 1.2 nM)。 了解更多
  11. AMD3100 (Plerixafor)

    Catalog No. A13074
    Quick View
    CXCR4 拮抗剂
    AMD3100 (Plerixafor)是用于增殖造血干细胞的免疫刺激剂,并且是用于动员造血干细胞进行移植的趋化因子受体-4拮抗剂。 了解更多
  12. SCH-527123 (Navarixin)

    Catalog No. A11555
    Quick View
    CXCR1/CXCR2 拮抗剂
    SCH-527123 (Navarixin)是人CXCR1和CXCR2受体的强效选择性拮抗剂,IC50分别为42 nM和3 nM。 了解更多
  13. SB265610

    Catalog No. A14195
    Quick View
    CXCR2 拮抗剂
    SB265610是CXCR2 (Kd = 2.51 nM)的非肽变构反向激动剂,通过与不同于激动剂结合位点的区域结合来防止受体活化。它不与相关CXCR1受体结合。在体外和高氧诱导肺损伤的大鼠模型中,它已被证明能防止中性粒细胞趋化性。 了解更多
  14. SB225002

    Catalog No. A14209
    Quick View
    CXCR2 拮抗剂
    SB225002是一种有效的选择性CXCR2拮抗剂,IC50为22 nM,可抑制白介素IL-8与CXCR2的结合,选择性是其他测试的7-TMR的150倍以上。 了解更多
  15. SCH 563705

    Catalog No. A15234
    Quick View
    CXCR2/CXCR1 拮抗剂
    SCH 563705是有效的双重CXCR2(IC50 = 1.3 nM)/CXCR1(IC50 = 7.3 nM)拮抗剂。 了解更多
  16. AMD-070 HCl

    Catalog No. A14997
    Quick View
    CXCR4 拮抗剂
    在CXCR4 125I-SDF抑制结合试验中,AMD-070 HCl是一种有效的选择性CXCR4拮抗剂,IC50值为13 nM,抑制T-4型HIV-1(NL4.3株)在MT-4细胞中的复制和PBMC。 了解更多
  17. UNBS5162

    Catalog No. A15439
    Quick View
    CXCL chemokines 拮抗剂
    UNBS5162是一种新型萘二甲酰亚胺,可降低实验性前列腺癌中CXCL趋化因子的表达。9种癌细胞系的平均抗增殖活性IC50值为17.9 uM;UNBS3157的水解产物。 了解更多
  18. AZD-5069

    Catalog No. A15941
    Quick View
    CXCR2 拮抗剂
    AZD-5069是一种有效的选择性CXCR2拮抗剂,具有抑制COPD患者中性粒细胞向气管迁移的潜能。 了解更多
  19. MSX-130

    Catalog No. A17150
    Quick View
    CXCR4 拮抗剂
    MSX-130是CXCR4拮抗剂。 了解更多
  20. USL311

    Catalog No. A18778
    Quick View
    CXCR4 拮抗剂
    USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. 了解更多
  21. CXCR2-IN-1

    Catalog No. A12649
    Quick View
    CXCR2 激动剂
    CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3. 了解更多
  22. AMG 487

    Catalog No. A21162
    Quick View
    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. 了解更多
  23. SCH 546738

    Catalog No. A21554
    Quick View
    CXCR3 antagonist
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. 了解更多
  24. AMG 487 S-enantiomer

    Catalog No. A21874
    Quick View
    CXCR3 antagonist
    AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3. 了解更多
  25. NBI-74330

    Catalog No. A21158
    Quick View
    CXCR3 antagonist
    NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. 了解更多
  26. IAXO-102

    Catalog No. A18543
    Quick View
    TLR4 antagonist
    IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. 了解更多
  27. Maraviroc (UK-427857)

    Catalog No. A10556
    Quick View
    CCR 拮抗剂
    Maraviroc (UK-427857)是CCR5受体拮抗剂类别的抗逆转录病毒药物,用于治疗HIV感染。 了解更多
  28. Vicriviroc Malate

    Catalog No. A10971
    Quick View
    CCR5 拮抗剂
    Vicriviroc Malate是CCR5拮抗剂,也是HIV-1进入靶细胞的有效抑制剂,对HIV分离株的平均IC50 = 0.46 nM,IC50 = 1?10 nM(n = 52)。 了解更多
  29. INCB8761 (PF-4136309)

    Catalog No. A11136
    Quick View
    CCR2 拮抗剂
    INCB8761 (PF-4136309)是一种有效的,选择性的,口服可生物利用的CCR2拮抗剂。 了解更多
  30. INCB 3284 dimesylate

    Catalog No. A11104
    Quick View
    HCCR2 拮抗剂
    INCB 3284 dimesylate是一种有效的选择性hCCR2拮抗剂,对单核细胞趋化因子分子与hCCR2的结合和趋化活性表现出强烈的拮抗作用。 了解更多
  31. MK-0812

    Catalog No. A11127
    Quick View
    CCR2 拮抗剂
    MK-0812是一种有效的选择性CCR2拮抗剂,对人单核细胞上CCR2的亲和力低,而在趋化性测定中的亲和力却低。它在临床前物种中具有良好的PK分布,并在动物模型中证明了功效。 了解更多
  32. BX471

    Catalog No. A14409
    Quick View
    CCR1 拮抗剂
    BX471是一种有效的选择性非肽CCR1拮抗剂(对于人CCR1,Ki = 1 nM),对CCR1的选择性是CCR2,CCR5和CXCR4的250倍。 了解更多
  33. TAK-779

    Catalog No. A13846
    Quick View
    CCR5 拮抗剂
    TAK-779是一种新颖,有效和选择性的CCR5小分子拮抗剂,在结合试验中IC50值为1.4nM。 了解更多
  34. RS 504393

    Catalog No. A15227
    Quick View
    CCR2 拮抗剂
    RS 504393是一种选择性CCR2趋化因子受体拮抗剂(IC50值分别为98 nM和> 100 uM,分别抑制人重组CCR2b和CCR1受体)。 了解更多
  35. Vicriviroc maleate

    Catalog No. A15276
    Quick View
    CCR5 拮抗剂
    Vicriviroc maleate是一种CCR5拮抗剂,在临床开发中用于治疗HIV-1的IC50为0.91 nM。 了解更多
  36. BMS-813160

    Catalog No. A17040
    Quick View
    CCR2/CCR5 拮抗剂
    BMS-813160是一种有效的选择性CCR2/CCR5拮抗剂,具有潜在的免疫调节和抗肿瘤活性。 了解更多
  37. BI-639667

    Catalog No. A18747
    Quick View
    Human CCR1 拮抗剂
    BI-639667 is a potent and selective antagonist of human CCR1. 了解更多
  38. PF-04634817

    Catalog No. A18659
    Quick View
    CCR2 /CCR5 dual 拮抗剂
    PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema. 了解更多
  39. INCB3344

    Catalog No. A11465
    Quick View
    CCR2 拮抗剂
    INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. 了解更多
  40. GW 766994

    Catalog No. A20039
    Quick View
    CCR3 拮抗剂
    GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. 了解更多
  41. AZ084

    Catalog No. A19143
    Quick View
    CCR8 拮抗剂
    AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. 了解更多
  42. CCR4 antagonist 2

    Catalog No. A18471
    Quick View
    CCR4 拮抗剂
    CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. 了解更多
  43. Teijin compound 1

    Catalog No. A13380
    Quick View
    CCR 2 antagonist
    Teijin compound 1 is a specific CCR 2 antagonist with IC50s of 24 and 180 nM in chemotaxis and binding assay, respectively. 了解更多
  44. GSK2239633A

    Catalog No. A12175
    Quick View
    CCR4 antagonist
    GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96????0.11. 了解更多
  45. PF-4136309

    Catalog No. A15127
    Quick View
    CCR2 antagonist
    PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. 了解更多
  46. RS102895 hydrochloride

    Catalog No. A20918
    Quick View
    CCR2 antagonist
    RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1. 了解更多
  47. Vercirnon

    Catalog No. A21315
    Quick View
    CCR9 antagonist
    Vercirnon (GSK-1605786) is an orally bioavailable, selective, and potent antagonist of CCR9, with an IC50 of 10 nM, used in the research of inflammatory bowel diseases. 了解更多
  48. BX471 hydrochloride

    Catalog No. A21886
    Quick View
    non-peptide CCR1 antagonist
    BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. 了解更多
  49. YM-90709

    Catalog No. A15999
    Quick View
    interleukin-5 receptor 拮抗剂
    YM-90709是白介素5受体拮抗剂。YM-90709抑制IL-5与其周围人嗜酸性粒细胞和丁酸处理的嗜酸性HL-60克隆15细胞的受体结合,IC50值分别为1.0和0.57 microM。 了解更多
  50. AF 12198

    Catalog No. A17213
    Quick View
    IL-1 receptor 拮抗剂
    AF 12198是人I型白介素1(IL-1)受体的有效选择性拮抗剂。 了解更多

50 个项目

每页

设置降序顺序
Rewards