Memantine hydrochloride是nmda受体的拮抗剂，与离子通道位点结合。它还是CYP2B6和CYP2D6抑制剂，作用于重组CYP2B6和CYP2D6，Ki分别为0.51 nM和94.9 μM。它被用于治疗帕金森综合征。 了解更多

Tamsulosin hydrochloride是一种选择性的α1受体拮抗剂，是用于良性前列腺增生的药物。 了解更多

Atrasentan hydrochloride是一种开发用于治疗前列腺癌的内皮素拮抗剂受体（IC50 = 0.0551 nM，ETA）。 了解更多

SCH 23390 HCl是一种有效的多巴胺受体拮抗剂（D1和D5受体亚型的Ki值分别为0.2 nM和0.3 nM）。 了解更多

Azasetron HCl是一种选择性的5-HT3受体拮抗剂，IC50为0.33 nM，用于治疗癌症化学疗法引起的恶心和呕吐。 了解更多

Melitracen HCl ia potential dopamine D1/2 receptor antagonist used to treat depression. It is often co-administered with flupenthixol as a treatment for trigeminal neuralgia. It does not effect cardiovascular function. 了解更多

MK 3207 hydrochloride是一种有效的CGRP受体拮抗剂，IC50为0.12 nM。 了解更多

Biperiden HCl是毒蕈碱受体拮抗剂，对M1亚型表现出一定的选择性。 了解更多

CP 945598 HCl (Otenabant HCl)是一种有效且高度选择性的CB1拮抗剂。 了解更多

A 438079 hydrochloride是一种竞争性P2X7受体拮抗剂（抑制人重组P2X7细胞系中Ca2+流入的pIC50 = 6.9）。 了解更多

Clemizole hydrochloride是H1组胺受体的拮抗剂，对NS4B RNA结合的IC50值为8 mM。 了解更多

MTEP hydrochloride是一种有效的，选择性和非竞争性的mGlu5拮抗剂，IC50和Ki分别为5 nM和16 nM。 了解更多

SB408124 Hydrochloride是OX1受体的非肽拮抗剂，全细胞和膜的Ki分别为57 nM和27 nM。表现出比OX2受体高50倍的选择性。 了解更多

Alosetron Hydrochloride是一种5-羟色胺5HT3受体拮抗剂，可用于治疗肠易激综合症。 了解更多

CP 465022 hydrochloride是一种选择性的非竞争性AMPA拮抗剂，在大鼠皮质神经元中的IC50为25 nM，显示出有效的抗惊厥活性。 了解更多

Prasugrel Hydrochloride是噻吩并吡啶ADP受体（P2Y12）拮抗剂，用于减少血栓性心血管事件。 了解更多

Cyproheptadine hydrochloride是抗组胺药，是5-羟色胺和组胺的拮抗剂。 了解更多

Tripelennamine hydrochloride, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine. 了解更多

Chlorcyclizine hydrochloride is a histamine H1 antagonist. 了解更多

Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic. 了解更多

MPEP HCl是对mGlu5a受体亚型（IC50 = 36 nM）的有效，高度选择性的非竞争性拮抗剂，但在浓度高达30 uM的mGlu1b受体上无激动剂或拮抗剂活性。 了解更多

ARL-15896是新型的N-甲基-D-天冬氨酸受体离子通道拮抗剂。 了解更多

Amprolium HCl是硫胺素拮抗剂，可通过阻止硫胺素吸收来阻止碳水化合物的合成。 了解更多

Oxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue). It is non-selective and inhibits both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively). Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively). 了解更多

BRL-15572是一种选择性的h5-HT1D拮抗剂，相对于h5-HT1B表现出60倍的选择性，对一系列其他受体类型的亲和力很小或没有亲和力。 了解更多

Naftopidil 2HCl是选择性5-HT1A和α1-肾上腺素能受体拮抗剂，IC50分别为0.1μM和0.2μM。 了解更多

GYKI-52466 dihydrochloride是选择性非竞争性AMPA受体拮抗剂(对于AMPA、红藻氨酸和AMPA诱导的反应，IC50值分别为10-20、~ 450和> > 50 μM)。 了解更多

cis-(Z)-Flupentixol dihydrochloride是多巴胺受体拮抗剂、抗精神病药物、抗精神病药物。 了解更多

SB 399885 hydrochloride是一种有效的，脑渗透剂和口服活性的SR-6拮抗剂。它对SR-6的选择性比其他血清素受体高200倍（对于人类重组，天然大鼠和天然人类SR-6受体，pKi值分别为9.11、8.81和9.02）。 了解更多

Atipamezole hydrochloride是一种选择性α2肾上腺素受体拮抗剂（α2A、α2B、α2C、α1A和α1B受体的Ki值分别为1.1、1.0、0.89、1300和6500nm）。已经被证明是大脑的渗透剂。 了解更多

SB 258585 hydrochloride是一种选择性和有效的SR-6拮抗剂。该化合物显示出比其他5-羟色胺受体亚型高160倍的选择性。 了解更多

Bavisant dihydrochloride是一种人类H3受体的高选择性，口服活性拮抗剂。 了解更多

Bavisant dihydrochloride hydrate是人类H3受体的高度选择性口服活性拮抗剂。 了解更多

DG-172是一种口服活性强效PPARβ/δ反向激动剂 (IC50 = 26.9 nM)。DG-172在体外抑制小鼠成肌细胞中Angptl4基因的表达 (IC50 = 9.5 nM)。 了解更多

SB 399885 hydrochloride是一种有效的，脑渗透剂和口服活性的SR-6拮抗剂。它对SR-6的选择性比其他血清素受体高200倍（对于人类重组，天然大鼠和天然人类SR-6受体，pKi值分别为9.11、8.81和9.02）。 了解更多

Lomerizine dihydrochloride是L型和T型Ca2+通道和TRp5通道的拮抗剂，用于治疗偏头痛和眩晕。 了解更多

Levocetirizine dihydrochloride is a L-isomer of cetirizine and histamine H1 receptor antagonist. It incrases levels of CD4+ CD25+ T cells and decreases levels of eosinophils, decreasing allergy symptoms. 了解更多

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. 了解更多

Etripamil (MSP-2017) is a short-acting L-type calcium-channel antagonist with a rapid onset of action designed for intranasal administration, used to treat Paroxysmal Supraventricular Tachycardia (PSVT). Etripamil (MSP-2017) slows atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells. 了解更多

CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood?Cbrain barrier after peripheral administration, with an IC50 of 32?μM. CGP 36742 is useful in treatment of depression. 了解更多

PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema. 了解更多

LY-2940094 is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY-2940094 reduces ethanol self-administration in animal models. 了解更多

Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist. 了解更多

JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception. 了解更多

Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. 了解更多

SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. 了解更多

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. 了解更多

JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder. 了解更多

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist. 了解更多