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Pseudouridimycin
Catalog No. A18520 RNA polymerase 抑制剂Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria. 了解更多 -
PF-06250112
Catalog No. A18612 BTK 抑制剂PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. 了解更多 -
BMS-986165
Catalog No. A18726 TYK2 抑制剂BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. 了解更多 -
Epristeride
Catalog No. A18231 5 alpha-reductase inhibitorEpristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. 了解更多 -
Fondaparinux Sodium
Catalog No. A17918 factor Xa inhibitorFondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). 了解更多 -
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最新产品
AZ304
Catalog No. A17225 dual BRAF 抑制剂AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. 了解更多 -
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JNJ-38877618
Catalog No. A18325 c-Met inhibitorJNJ-38877618 is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. 了解更多 -
Porcn-IN-1
Catalog No. A18330 Potent porcupine inhibitorPorcn-IN-1 is potent porcupine inhibitor with an IC50 of 0.5??0.2 nM. 了解更多 -
GSK 2250665A
Catalog No. A17191 Itk 抑制剂GSK-2250665A是pKi = 9.2的Itk抑制剂，它对Aurora B激酶和Btk（pIC50值分别为6.4和6.5）和一组其他激酶表现出对Itk的选择性。 抑制PBMC中IFNγ的产生。 了解更多 -
Antineoplaston A10
Catalog No. A17183 -
Nedisertib
Catalog No. A17055 DNA-PK 抑制剂Nedisertib (M-3814,MSC2490484A)是一种可口服的DNA依赖性蛋白激酶（DNA-PK）抑制剂，具有潜在的抗肿瘤和化学/放射增敏活性。 了解更多 -
KDU691
Catalog No. A17066 -
PF-06855800
Catalog No. A16860 PRMT5 抑制剂PF-06855800 (PF06855800)是一种有效的，选择性的，SAM竞争性，BBB渗透性，口服活性的蛋白精氨酸甲基转移酶PRMT5抑制剂，Ki为0.02 nM。 了解更多 -
GSK-3326595 (EPZ015938)
Catalog No. A16862 PRMT5 抑制剂GSK-3326595 (EPZ015938)是一种有效的，选择性的，可逆的蛋白精氨酸甲基转移酶5（PRMT5）抑制剂，IC50为6.2 nM。 了解更多 -
CB-1158
Catalog No. A16864 -
AZD3229 Tosylate
Catalog No. A16867 -
PF-06873600
Catalog No. A16875 CDK 抑制剂PF-06873600是一种口服生物利用型，细胞周期蛋白依赖性激酶（CDK）抑制剂，其对 CDK2、CDK4和CDK6的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM。具有潜在的抗肿瘤活性。 了解更多 -
NSC117079
Catalog No. A16894 -
ICEC0942 HCl
Catalog No. A16903 CDK7 抑制剂ICEC0942 HCl，也称为CT7001，是CDK7的口服生物利用选择性抑制剂。它选择性抑制CDK7，IC50为40nM。CDK1，CDK2，CDK5和CDK9的IC50值分别高45倍，15倍，230倍和30倍。 了解更多 -
Vorasidenib
Catalog No. A16908 IDH1 抑制剂Vorasidenib (AG-881)是一种有效且选择性的口服抑制剂，可抑制细胞质中异柠檬酸脱氢酶1型(IDH1，IDH1 [NADP+]可溶)和2型（IDH2异柠檬酸脱氢酶[NADP+]）的突变形式。线粒体中的线粒体，具有潜在的抗肿瘤活性。 了解更多 -
KIN001-051
Catalog No. A16923 Lck 抑制剂KIN001-051是一种有效的、选择性的Lck抑制剂。淋巴细胞特异性蛋白酪氨酸激酶（Lck）是非受体蛋白酪氨酸激酶Src家族的成员，在触发细胞因子产生的T细胞受体信号转导的初始步骤中起着至关重要的作用。 了解更多 -
CB-1158
Catalog No. A16929 -
CAY10566
Catalog No. A16936 -
LF3
Catalog No. A16851 -
LXH254
Catalog No. A16841 -
Ruxolitinib Phosphate
Catalog No. A11552 JAK 抑制剂Ruxolitinib Phosphate是ruxolitinib的磷酸盐形式，ruxolitinib是一种口服生物可利用的Janus相关激酶(JAK)抑制剂，具有潜在的抗肿瘤和免疫调节活性。 了解更多 -
Amfenac Sodium Monohydrate
Catalog No. A16399 COX 抑制剂Amfenac Sodium Monohydrate是一种非甾体止痛消炎药，带有乙酸部分。COX1和COX2的IC50值分别为250 nM和150 nM。 了解更多 -
Apogossypolone (ApoG2)
Catalog No. A16314 -
Apoptosis Inhibitor (M50054)
Catalog No. A13058 -
D609
Catalog No. A11388 -
TRx0237 (LMTX) mesylate
Catalog No. A16124 tau protein aggregation 抑制剂TRx0237 (LMTX) mesylate是第二代tau蛋白聚集抑制剂，可用于治疗阿尔茨海默氏病（AD）和额颞痴呆。 了解更多 -
SPL-B
Catalog No. A16085
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