PDE

Catalog No.Inhibitor Name PDEPDE1PDE2PDE3PDE4PDE5PDE6PDE9APDE10AOther
A10804Roflumilast
****
A10216Cilomilast
***
A10883Tadalafil
***
A10733Pimobendan
**
A11073GSK256066
****
A11191PF-2545920
****
A10805Rolipram
**
A10217Cilostazol
**
A10592Milrinone
**
**
ATPase
A12619Avanafil
****
A10066Aminophylline
*
adenosine receptor
A15799TAK-063
****
A13722Deltarasin
***
A10541Luteolin
*
*
*
*
*
A10464Icariin
**
mAChR,AChR
A10480Irsogladine
A10319Dipyridamole
A10339Dyphylline
A11527PF-8380
***
A10965Vardenafil
***
****
A11019Ibudilast (KC-404)
A11289Apremilast (CC 10004)
***
A11326Bay 60-7550
****
A11602Vinpocetine
Sodium channel
A12550Zardaverine
**
**
A12631Sildenafil
***
***
A12776AN2728
***
A13121PF-04447943
***
A13467MK-0359
A13596Cilostamide
***
A15191Nortadalafil
A15197Oglemilast
****
A15198Olprinone Hydrochloride

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 71个

每页
页面:
  1. 1
  2. 2

设置降序顺序
  1. Deltarasin HCl

    Catalog No. A13722
    Quick View
    PDE-KRAS 抑制剂
    Deltarasin HCl是一种新型的抑制KRASPDEδ相互作用从而破坏致癌性KRAS信号的小分子。 了解更多
  2. HA130

    Catalog No. A15546
    Quick View
    Autotaxin 抑制剂
    HA130是一种选择性的autotaxin (ATX)抑制剂,IC50为 28 nM。 了解更多
  3. PF-8380

    Catalog No. A11527
    Quick View
    Autotaxin 抑制剂
    PF-8380是一种强效和特异的自动调节蛋白抑制剂,IC50值为2.8 nM。 了解更多
  4. Tadalafil

    Catalog No. A10883
    Quick View
    PDE5 抑制剂
    Tadalafil是一种PDE5抑制剂,IC50值为1.8 nM。 了解更多
  5. Sildenafil Mesylate

    Catalog No. A16142
    Quick View
    PDE5 抑制剂
    Sildenafil Mesylate是西地那非的甲磺酸盐形式,西地那非是磷酸二酯酶5的抑制剂。 了解更多
  6. Udenafil

    Catalog No. A13291
    Quick View
    PDE5 抑制剂
    Udenafil是一种PDE5抑制剂,用于泌尿科治疗勃起功能障碍。 了解更多
  7. Vesnarinone

    Catalog No. A13313
    Quick View
    PDE3 抑制剂
    Vesnarinone是一种喹啉酮衍生物,其药效作用包括抑制磷酸二酯酶III(PDE3)活性,增加钙通量和减少钾通量。 了解更多
  8. BW-A78U

    Catalog No. A17098
    Quick View
    PDE4 抑制剂
    BW-A78U是PDE4抑制剂,IC50为3μM。 了解更多
  9. BAY 73-6691

    Catalog No. A17024
    Quick View
    PDE9 抑制剂
    BAY 73-6691是一种有效的选择性脑渗透性PDE9A抑制剂。 了解更多
  10. BRL-50481

    Catalog No. A17008
    Quick View
    PDE7 抑制剂
    BRL-50481充当对PDE7亚型具有选择性的磷酸二酯酶抑制剂。 了解更多
  11. Roflumilast N-oxide

    Catalog No. A16984
    Quick View
    PDE4 抑制剂
    Roflumilast N-oxide是罗氟司特的活性代谢产物。Roflumilast N-oxide是磷酸二酯酶4抑制剂。 了解更多
  12. Ademetionine

    Catalog No. A17531
    Quick View
    PDE4B inhibitor
    Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. 了解更多
  13. Lodenafil

    Catalog No. A18029
    Quick View
    PDE5 inhibitor
    Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). 了解更多
  14. Fosphenytoin disodium

    Catalog No. A18184
    Quick View
    PDE3 inhibitor
    Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. 了解更多
  15. CM-675

    Catalog No. A18741
    Quick View
    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. 了解更多
  16. BPN14770

    Catalog No. A18663
    Quick View
    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. 了解更多
  17. MT-3014

    Catalog No. A18580
    Quick View
    PDE 10A inhibitor
    MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. 了解更多
  18. PDE12-IN-3

    Catalog No. A18579
    Quick View
    PDE12 inhibitor
    PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. 了解更多
  19. VP3.15

    Catalog No. A18538
    Quick View
    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多
  20. TPN171

    Catalog No. A18464
    Quick View
    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. 了解更多
  21. PF-05085727

    Catalog No. A20098
    Quick View
    PDE2A inhibitor
    PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. 了解更多
  22. R 80123

    Catalog No. A21836
    Quick View
    phosphodiesterase inhibitor
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. 了解更多
  23. Cilostazol

    Catalog No. A10217
    Quick View
    PDE3 抑制剂
    Cilostazol是3型磷酸二酯酶(PDE3)的选择性抑制剂,IC50为0.2 μM,其治疗重点是cAMP。 了解更多
  24. Rolipram

    Catalog No. A10805
    Quick View
    PDE4 抑制剂
    Rolipram是一种PDE4抑制剂,IC50 = 2.0μM。 了解更多
  25. Icariin

    Catalog No. A10464
    Quick View
    PDE5 抑制剂
    Icariin对抑制PDE5A1、PDE5A2和PDE5A3的所有三种PDE5A亚型均有抑制作用,IC50值分别为1.0、0.75和1.1 μM。 了解更多
  26. Pimobendan (Vetmedin)

    Catalog No. A10733
    Quick View
    PDE 抑制剂
    Pimobendan (Vetmedin)是一种钙增敏剂,具有正性肌力和血管舒张作用。它也是磷酸二酯酶III(PDE3)的选择性抑制剂。 了解更多
  27. GSK256066

    Catalog No. A11073
    Quick View
    PDE 抑制剂
    GSK256066是PDE4的极高亲和力和选择性抑制剂,它以相等的亲和力抑制PDE4亚型A-D,并具有很高的HARBS(高亲和力利普兰结合位点)比率(> 17)。 了解更多
  28. PF-2545920

    Catalog No. A11191
    Quick View
    PDE10A 抑制剂
    PF-2545920是对PDE10A亚型具有选择性的磷酸二酯酶抑制剂。 了解更多
  29. Ibudilast (KC-404)

    Catalog No. A11019
    Quick View
    PDE 抑制剂
    Ibudilast (KC-404)是一种相对非选择性的phosphodiesterase抑制剂,具有抗炎和神经保护活性。 了解更多
  30. Cilomilast (SB-207499)

    Catalog No. A10216
    Quick View
    PDE-4 抑制剂
    Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂,具有抗炎作用。可针对与COPD相关的支气管收缩,粘液分泌过多和气道重塑。 了解更多
  31. Hesperetin

    Catalog No. A10449
    Quick View
    PDE4 抑制剂
    Hesperetin是一种选择性磷酸二酯酶(PDE)4抑制剂,存在于中药“陈皮”中。橙皮素是一种柑橘类黄酮,据报道可以降低血浆胆固醇。橙皮素降低Hep-G2细胞中ACAT-2 mRNA的转录,并以剂量依赖的方式降低ApoB蛋白的合成。它也是类癌的潜在疗法。 了解更多
  32. Luteolin

    Catalog No. A10541
    Quick View
    PDE4 抑制剂
    Luteolin是PDE4抑制剂、磷酸二酯酶抑制剂和白细胞介素6抑制剂,影响木聚嗪/氯胺酮诱导的小鼠麻醉。Luteolin作为单胺转运蛋白激活剂,是少数证明具有这种性质的化学物质之一。 了解更多
  33. Apremilast (CC 10004)

    Catalog No. A11289
    Quick View
    PDE4 抑制剂
    Apremilast (CC 10004)是一种新型的PDE4抑制剂,可抑制人类风湿性滑膜细胞自发产生肿瘤坏死因子-α,并改善实验性关节炎。 了解更多
  34. Vardenafil

    Catalog No. A10965
    Quick View
    PDE-5 抑制剂
    Vardenafil是用于治疗勃起功能障碍的PDE5抑制剂。 了解更多
  35. Roflumilast

    Catalog No. A10804
    Quick View
    PDE 抑制剂
    Roflumilast可作为PDE-4酶的选择性长效抑制剂,无细胞试验中IC50为0.2-4.3 nM。 了解更多
  36. Bay 60-7550

    Catalog No. A11326
    PDE-2 抑制剂
    Bay 60-7550是一种强效PDE2抑制剂,IC50值为2.0 nM(牛)和4.7 nM(人)。 了解更多
  37. Dipyridamole

    Catalog No. A10319
    Quick View
    PDE 抑制剂
    Dipyridamole (Persantine)是一种磷酸二酯酶抑制剂,可阻止红细胞和血管内皮细胞摄取和代谢腺苷。 了解更多
  38. Milrinone (Primacor)

    Catalog No. A10592
    Quick View
    PDE3 抑制剂
    Milrinone (Primacor)是一种有效的选择性磷酸二酯酶3抑制剂,IC50为0.42μM,可抑制FIII PDE。 了解更多
  39. Zardaverine

    Catalog No. A12550
    Quick View
    PDE 3/4 抑制剂
    Zardaverine是一种磷酸二酯酶抑制剂,对PDE3和4具有选择性(IC50值分别为0.5和0.8 uM)。 了解更多
  40. Avanafil

    Catalog No. A12619
    Quick View
    PDE5 抑制剂
    Avanafil是用于治疗勃起功能障碍的PDE5抑制剂,IC50为5.2 nM,对PDE1,PDE6和PDE11活性较低。 了解更多
  41. PF-04447943

    Catalog No. A13121
    Quick View
    PDE9 抑制剂
    PF-04447943是一种有效的选择性脑渗透pde9抑制剂,在大鼠和小鼠的多种认知模型中增加海马突触可塑性的指标并改善认知功能。 了解更多
  42. Crisaborole (AN2728)

    Catalog No. A12776
    Quick View
    PDE4 抑制剂?
    AN2728是一种局部给药的含硼抗炎化合物,可抑制PDE4活性,从而抑制TNFalpha,IL-12,IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。 了解更多
  43. D159687

    Catalog No. A21228
    Quick View
    PDE4D inhibitor
    D159687 is a selective PDE4D inhibitor. 了解更多
  44. PF-04957325

    Catalog No. A21246
    Quick View
    PDE8 inhibitor
    PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. 了解更多
  45. Mirodenafil

    Catalog No. A21260
    Quick View
    PDE-5 inhibitor
    Mirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多
  46. Saterinone hydrochloride

    Catalog No. A21402
    Quick View
    PDE3 inhibitor
    Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. 了解更多
  47. ITI214

    Catalog No. A21422
    Quick View
    PDE1 inhibitor
    ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多
  48. AMG 579

    Catalog No. A21478
    Quick View
    PDE10A inhibitor
    AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. 了解更多
  49. BAY 73-6691 racemate

    Catalog No. A21745
    Quick View
    PDE9 inhibitor
    BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. 了解更多
  50. VP3.15 dihydrobromide

    Catalog No. A21789
    Quick View
    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多

产品 1 到 50 共 71个

每页
页面:
  1. 1
  2. 2

设置降序顺序
Rewards