FGFR

Catalog No.Inhibitor Name FGFRFGFR1FGFR2FGFR3FGFR4Other
A10080Ponatinib
****
Abl,PDGFRα,VEGFR2
A11159BGJ398
****
****
****
**
VEGFR2,Lyn,Kit
A10137Nintedanib
**
**
**
*
VEGFR3,VEGFR2,LCK
A10703PD173074
**
VEGFR2,c-Src
A11411Dovitinib
***
***
FLT3,c-Kit,VEGFR3/FLT4
A11075AZD4547
****
****
****
*
KDR,IGFR
A10715Danusertib
**
Aurora A,Abl,TrkA
A10953Orantinib
*
PDGFRβ,Flk1
A10254Brivanib
*
VEGFR2,Flk1,VEGFR1
A10198Dovitinib Dilactic Acid
***
***
FLT3,c-Kit,VEGFR3/FLT4
A11753MK-2461
**
**
**
A10162Brivanib Alaninate
*
VEGFR2,Flk1,VEGFR1
A13211SSR128129E
*
VEGFR2,PDGFRβ
A11558SU5402
**
A15534BLU9931
*
*
*
****
A12357FIIN-2
****
***
**
**
FLT3,c-Kit,VEGFR3/FLT4
A14415CH5183284
***
***
***
*
VEGFR2
A11244LY2874455
****
****
***
***
A15957Erdafitinib
A10508KW-2449
**
FLT3, Bcr-Abl, Aurora A, PDGFRβ, IGF-1R, EGFR
A10699Pazopanib HCl
*
VEGFR1, VEGFR2, VEGFR3, PDGFR, c-Kit, c-Fms
A11518Pazopanib
*
VEGFR1, VEGFR2, VEGFR3, PDGFR, c-Kit, c-Fms
A13111R 1530
*
Chk2, KDR, FGFR, Aurora A, Cdk2, VEGFR-2, PDGFRβ
A15073E-3810
***
**
VEGFR1, VEGFR2, VEGFR3
A15848FIIN-3
***
**
**
**
A15957Alofanib (RPT835)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Brivanib alaninate (BMS-582664)

    Catalog No. A10162
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    VEGFR 抑制剂
    Brivanib alaninate (BMS-582664)是VEGFR和FGFR信号转导的双重酪氨酸激酶抑制剂。 了解更多
  2. E-3810

    Catalog No. A15073
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    VEGFR/FGFR 抑制剂
    E-3810是一种有效且选择性的VEGF和FGF受体双重抑制剂,对VEGFR-1,VEGFR-2,VEGFR-3,FGFR-1和VEGF的IC50值分别为7nM,25nM,10nM,17.5nM和82.5nM。FGFR-2。 了解更多
  3. Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  4. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR 抑制剂
    Pazopanib (GW-786034)是VEGFR-1,VEGFR-2,VEGFR-3,PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂,可阻止肿瘤生长并抑制血管生成。 了解更多
  5. Dovitinib (TKI-258)

    Catalog No. A11411
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  6. Brivanib (BMS-540215)

    Catalog No. A10254
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    VEGFR-2 抑制剂
    Brivanib (BMS-540215)是一种VEGFR-2抑制剂,IC50为25 nM,Ki为26 nM。 了解更多
  7. Nintedanib esylate

    Catalog No. A16197
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    RTK 抑制剂
    Nintedanib esylate是多种受体酪氨酸激酶(RTK)和非受体酪氨酸激酶(nRTK)的有效抑制剂。 了解更多

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