你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
搜索结果：“jwh 250”

“jwh 250”的搜索结果

Quick View
AZD6244 (Selumetinib)

Catalog No. A10257
Quick View

添加到收藏
MEK 抑制剂

Selumetinib (AZD6244)是一种有效，高选择性的MEK抑制剂，ARRY142886，AZD-6244和ARRY-142886是MEK 1/2抑制剂，GI50值在14至50 nm之间。了解更多

Product Citations (1)

Bulk Inquiry
- Chia-Chi Chang, .et al. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 PMID: 27150057
Quick View
U0126-EtOH

Catalog No. A10957
Quick View

添加到收藏
MEK 抑制剂

U0126-EtOH是MEK1和MEK2的抑制剂，IC50分别为72 nM和58 nM。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Hanna Galganska, .et al. Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors, Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
- Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007
Quick View
Regorafenib (BAY 73-4506)

Catalog No. A10250
Quick View

添加到收藏
VEGFR 抑制剂

Regorafenib (BAY 73-4506)是一种多激酶抑制剂，IC50为17、40和69 nM c-KIT，VEGFR2，B-Raf。Regorafenib（BAY 73-4506）是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。了解更多

Product Citations (9)

Bulk Inquiry Free Sample
- Paula Sagmeister, .et al. Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis, J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
- Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
- Jindal A, .et al. Milciclib and sorafenib synergistically downregulate c-Myc to suppress tumor growth in an orthotopic murine model of human hepatocellular carcinoma, J Transl Sci, 2020, 7: 1-10
- Makoto Koyama, .et al. Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells, Int J Oncol, 2020, Sep 2 PMID: 32901840
- Mariko Fujisawa, .et al. Involvement of the Interferon Signaling Pathways in Pancreatic Cancer Cells, Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774
- Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298
- Sunil Kumar Yadava, .et al. Low Temperature, Easy Scaling Up Method for Development of Smart Nanostructure Hybrid Lipid Capsules for Drug Delivery Application, Colloids Surf B Biointerfaces, 2020, Mar 2;190:110927 PMID: 32169777
- Takeshi Uenaka, .et al. In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease, Hum Mol Genet, 2018, Nov 15; 27(22): 3974-3985 PMID: 30137437
- Yi Xu, .et al. Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2, Free Radic Biol Med, 2016, Jul; 96: 67-77 PMID: 27101738
Quick View
LY2228820 (Ralimetinib)

Catalog No. A10545
Quick View

添加到收藏
p38 MAPK 抑制剂

LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。了解更多

Bulk Inquiry Free Sample
Quick View
Asiatic acid

Catalog No. A10092
Quick View

添加到收藏
Anti-inflammatory agent

Asiatic acid常用于伤口愈合。亚洲酸具有抗氧化，抗炎和神经保护的特性。积雪草酸衍生物的合成可用作抗癌剂；糖原磷酸化酶抑制剂；保肝剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Rakhi Mishra, .et al. Comparative study of High-performance thin-layer chromatography and Antioxidant potential of Hydrocotyle asiatica mother tincture used in Homoeopathy, Indian J Res Homoeopathy, 2022, Sep 27
Quick View
AS 602801 (Bentamapimod)

Catalog No. A11296
Quick View

添加到收藏
JNK 抑制剂

AS 602801 (Bentamapimod)是一种新型口服活性Jun激酶抑制剂。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Shuai Zhang, .et al. AS602801 sensitizes glioma cells to temozolomide and vincristine by blocking gap junction communication between glioma cells and astrocytes, J Cell Mol Med, 2021, Apr;25(8):4062-4072 PMID: 33609076
- Kuramoto K, .et al. AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes, Anticancer Res, 2018, Sep;38(9):5093-5099 PMID: 30194154
Quick View
Dabrafenib (GSK2118436A)

Catalog No. A11381
Quick View

添加到收藏
Raf 抑制剂

Dabrafenib (GSK2118436A)是一种有效且选择性的B-RAF蛋白激酶抑制剂，具有V600E突变，目前正在临床试验中。了解更多

Product Citations (6)

Bulk Inquiry Free Sample
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Chenyang He, .et al. Detection of Dabrafenib using Optical Fibre Long Period Grating Sensor Modified with Surface Imprinted Polymers for Dose Detection and Prevention of Cancer Resistance, Clinical and Translational Biophotonics, 2020, TTh3B.2
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Quick View
TCS JNK 5a

Catalog No. A11969
Quick View

添加到收藏
JNK 抑制剂 IX

TCS JNK 5a是JNK2和JNK3的高度选择性抑制剂（对于JNK3，JNK2，JNK1和p38β，pIC50值分别为6.7、6.5，<5.0和<4.8）。了解更多

Bulk Inquiry Free Sample
Quick View
MLN2480 (BIIB-024)

Catalog No. A11240
Quick View

添加到收藏
pan-Raf 抑制剂

MLN2480 (BIIB-024)是一种口服的Raf激酶抑制剂。了解更多

Bulk Inquiry
Quick View
RO4927350

Catalog No. A11247
Quick View

添加到收藏
MEK1/2 抑制剂

RO4927350是一种有效且高度选择性的非ATP竞争性MEK1/2抑制剂。了解更多

Bulk Inquiry
Quick View
TCS ERK 11e (VX-11e)

Catalog No. A12505
Quick View

添加到收藏
ERK2 抑制剂

TCS ERK 11e (VX-11e)是一种有效且选择性的细胞外信号相关激酶2（ERK2）抑制剂（ERK2，GSK-3，Aurora激酶A和Cdk2的Ki值分别<2、395、540和852 nM）。有效阻断HT29细胞的增殖（IC50 = 48 nM）。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Qi-sang Guo, etc. Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. Sci Rep. 2017; 7: 2117.
Quick View
ML-3043

Catalog No. A12408
Quick View

添加到收藏
p38 MAPK 抑制剂

ML-3043是p38 MAPK抑制剂（IC50 = 0.38μM）。在外周血单核细胞（PBMC）分析中抑制IL-1β和TNF-α的释放（IC50值分别为0.039和0.16μM）。了解更多

Bulk Inquiry
Quick View
CGP 57380

Catalog No. A13883
Quick View

添加到收藏
MNK2 抑制剂

CGP 57380是MAP激酶相互作用激酶1（Mnk1，MKNK1）（IC50 = 2.2 uM）的抑制剂。了解更多

Bulk Inquiry
Quick View
Hypothemycin

Catalog No. A13750
Quick View

添加到收藏
Hypothemycin是间苯二酸内酯聚酮。已发现抑制用抗CD3 mAb+ PMA刺激的小鼠和人T细胞以及仅用抗CD3 mAb刺激的人PBMC的增殖。了解更多

Bulk Inquiry
Quick View
FR 180204

Catalog No. A14119
Quick View

添加到收藏
ERK 抑制剂

FR 180204是细胞外信号调节激酶（ERK）的新型选择性抑制剂，它可能是类风湿关节炎的潜在新疗法。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
- Dyshlovoy SA, .et al. Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin, Proteomics, 2017, Jun;17(11) PMID: 28445005
Quick View
B-Raf-inhibitor 1

Catalog No. A14122
Quick View

添加到收藏
B-Raf 抑制剂

B-Raf inhibitor 1是有效的选择性B-Raf抑制剂，对A375增殖和A375 p-ERK的细胞IC50分别为0.31 uM和2 nM。了解更多

Bulk Inquiry Free Sample
Quick View
CEP-32496

Catalog No. A13772
Quick View

添加到收藏
Raf 抑制剂

CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1（B-raf）丝氨酸/苏氨酸蛋白激酶抑制剂，具有潜在的抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
SB-242235

Catalog No. A13678
Quick View

添加到收藏
p38 MAPK 抑制剂

SB-242235是一种有效的选择性p38 MAP激酶抑制剂，可能是细胞因子介导的疾病（例如自身免疫或炎性疾病）的有效疗法。了解更多

Bulk Inquiry
Quick View
BI-78D3

Catalog No. A13683
Quick View

添加到收藏
JNK 抑制剂

BI-78D3是一种竞争性JNK（c-Jun N端激酶）抑制剂（IC50 = 280 nM），其选择性是p38α的100倍以上，在mTOR和PI-3K上无活性。 BI 78D3抑制JIP1（JNK相互作用蛋白1）JNK结合（IC50 = 500 nM）。了解更多

Bulk Inquiry
Quick View
RWJ-67657

Catalog No. A13552
Quick View

添加到收藏
p38 MAPK 抑制剂

RWJ-67657是有效的p38 MAPK抑制剂。了解更多

Bulk Inquiry
Quick View
Cobimetinib (R-enantiomer)

Catalog No. A15051
Quick View

添加到收藏
MEK 抑制剂

Cobimetinib R-enantiomer是Cobimetinib的R对映异构体，Cobimetinib是一种有力的，高选择性的促分裂原活化蛋白激酶（MEK1/2）抑制剂。了解更多

Bulk Inquiry
Quick View
GDC-0623

Catalog No. A12974
Quick View

添加到收藏
MEK1 抑制剂

GDC-0623是一种有效的ATP竞争性MEK1抑制剂，Ki为0.13 nM。了解更多

Bulk Inquiry
Quick View
AMG 548

Catalog No. A10970
Quick View

添加到收藏
p38 MAPK 抑制剂

AMG 548是有效的p38α选择性抑制剂。它对其他36种激酶表现出> 1000倍的选择性，并且抑制全血LPS刺激的TNFα。了解更多

Bulk Inquiry
Quick View
ML 786 dihydrochloride

Catalog No. A11211
Quick View

添加到收藏
Raf 抑制剂

ML 786 dihydrochloride是一种有效的Raf激酶抑制剂（B-RafV600E，C-Raf和野生型B-Raf的IC50值分别为2.1、2.5和4.2 nM）。了解更多

Bulk Inquiry
Quick View
PD 334581

Catalog No. A16044
Quick View

添加到收藏
MEK1 抑制剂

PD 334581在生物学研究中用于评估卤素键合，作为合理药物设计的新型相互作用。它也是MEK1的抑制剂。了解更多

Bulk Inquiry
Quick View
Locostatin

Catalog No. A16079
Quick View

添加到收藏
RKIP/Raf1 抑制剂

Locostatin是Raf激酶抑制剂蛋白（RKIP/Raf1激酶相互作用的细胞渗透性强抑制剂，是细胞迁移的抑制剂。了解更多

Bulk Inquiry
Quick View
LXH254

Catalog No. A16841
Quick View

添加到收藏
pan-RAF 抑制剂

LXH254是II型ATP竞争性抑制剂，可在皮摩尔浓度下抑制B/C RAF激酶活性，对456种人类激酶和基于细胞的测定具有高度选择性。了解更多

Bulk Inquiry
Quick View
- 最新产品
AZ304

Catalog No. A17225
Quick View

添加到收藏
dual BRAF 抑制剂

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. 了解更多

Bulk Inquiry
Quick View
LUT014

Catalog No. A19449
Quick View

添加到收藏
B-Raf inhibitor

LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 . 了解更多

Bulk Inquiry
Quick View
B-Raf IN 1

Catalog No. A21055
Quick View

添加到收藏
B-Raf kinase inhibitor

B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. 了解更多

Bulk Inquiry
Quick View
Ralimetinib

Catalog No. A21942
Quick View

添加到收藏
p38 MAPK α/β inhibitor

Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. 了解更多

Bulk Inquiry

联系我们

Not your Region? View all Distributors

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.