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￥ 0.00 Neuronal Signaling
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FK 3311
Catalog No. A13332 -
Flufenamic acid
Catalog No. A13333 COX 抑制剂Flufenamic acid是一种非甾体类抗炎药（NSAID）。抑制钙激活的氯离子通道（CaCC）。也增加通过TRPC6通道的电流，并抑制通过TRPC3和TRPC7通道的电流。 了解更多 -
Valdecoxib
Catalog No. A13342 COX-2 抑制剂伐地考昔（Valdecoxib），也称为SC-65872，是一种非甾体类抗炎药（NSAID），用于治疗骨关节炎，类风湿性关节炎以及痛经和月经症状。 它是一种选择性的环氧合酶2（COX-2)抑制剂,IC50为5nM。 了解更多 -
Meclofenamate Sodium
Catalog No. A12520 -
Etoricoxib
Catalog No. A13770 COX-2 抑制剂Etoricoxib特异性结合并抑制环氧合酶2（COX-2），从而抑制花生四烯酸向前列腺素的转化。抑制COX-2可以诱导细胞凋亡并抑制肿瘤细胞的增殖和血管生成。 了解更多 -
Xanthohumol
Catalog No. A15919 -
SC 560
Catalog No. A13023 -
Etodolac (AY-24236)
Catalog No. A10371 COX inhibitorEtodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). 了解更多 -
Eicosatetraynoic acid
Catalog No. A19008 COX/LOX inhibitorEicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? 了解更多 -
Naproxen etemesil
Catalog No. A13052 COX-1 and COX-2 inhibitorNaproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多 -
Diclofenac diethylamine
Catalog No. A16503 COX inhibitorDiclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. 了解更多 -
Diclofenac
Catalog No. A17814 COX inhibitorDiclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. 了解更多 -
Etoricoxib D4
Catalog No. A21877 COX-2 inhibitorEtoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. 了解更多 -
Timosaponin b-II
Catalog No. A14591 -
Verubecestat (MK-8931)
Catalog No. A16113 β-secretase/BACE1 抑制剂Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂，是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。 了解更多 -
BACE1-IN-4
Catalog No. A18462 BACE1 inhibitorBACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多 -
PF-06751979
Catalog No. A20066 BACE1 inhibitorPF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多 -
Umibecestat (CNP520)
Catalog No. A18987 BACE-1 inhibitorUmibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多 -
Lanabecestat
Catalog No. A12282 BACE1 inhibitorLanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多 -
BACE1-IN-1
Catalog No. A12183 BACE1 inhibitorBACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多 -
β-Secretase Inhibitor IV
Catalog No. A21346 BACE-1 inhibitorβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多 -
AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase 抑制剂DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
BMS 433796
Catalog No. A11337 -
BMS 299897
Catalog No. A12444 γ-secretase 抑制剂BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。 了解更多 -
LY3039478
Catalog No. A13544 -
JLK 6
Catalog No. A15301 -
PF-03084014
Catalog No. A11259 -
Flurbiprofen Axetil
Catalog No. A13662 -
L-685458
Catalog No. A15899 -
Begacestat (GSI-953)
Catalog No. A11258 -
Z-Ile-Leu-aldehyde
Catalog No. A16215
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- β-Amyloid (6)
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- AChE (20)
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- nAChR (4)
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- GlyT (4)
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- 5-lipoxygenase (1)
- COX (13)
- COX-1 (13)
- COX-2 (23)
- Histamine H1 receptor (1)
- HSP90 (1)
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- Src (1)
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