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PROTAC Degrader

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  1. PROTAC CRBN Degrader-1
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    PROTAC CRBN Degrader-1

    Catalog No. A18863
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    CRBN degrader
    PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. 了解更多
  2. PROTAC ERRα Degrader-2
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    PROTAC ERRα Degrader-2

    Catalog No. A18904
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    ERRa degrader
    PROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  3. PROTAC ERRα Degrader-1
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    PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  4. FKBP12 PROTAC dTAG-7
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    FKBP12 PROTAC dTAG-7

    Catalog No. A19081
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    heterobifunctional degrader
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. 了解更多
  5. THAL-SNS-032
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    THAL-SNS-032

    Catalog No. A19088
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    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
  6. PROTAC FLT-3 degrader 1
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    PROTAC FLT-3 degrader 1

    Catalog No. A18682
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    FLT-3 ITD degrader
    PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. 了解更多
  7. PROTAC ER Degrader-3
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    PROTAC ER Degrader-3

    Catalog No. A18519
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    PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多
  8. ARV-771
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    ARV-771

    Catalog No. A13255
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    BET degrader
    ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. 了解更多
  9. ZXH-3-26
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    ZXH-3-26

    Catalog No. A18399
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    PROTAC BRD4 degrader
    ZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM. 了解更多
  10. ERD-308
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    ERD-308

    Catalog No. A18446
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    ER PROTAC degrader
    ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. 了解更多
  11. MT-802
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    MT-802

    Catalog No. A18589
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    BTK degrader
    MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). 了解更多
  12. VZ185
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    VZ185

    Catalog No. A18685
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    dual BRD7/9 PROTAC degrader
    VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively. 了解更多
  13. MD-224
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    MD-224

    Catalog No. A18712
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    MDM2 degrader
    MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. 了解更多
  14. PROTAC Bcl2 degrader-1
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    PROTAC Bcl2 degrader-1

    Catalog No. A18355
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    degrader
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. 了解更多
  15. dMCL1-2
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    dMCL1-2

    Catalog No. A18378
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    MCL-1/PROTAC degrader
    dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1. 了解更多
  16. BETd-260
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    BETd-260

    Catalog No. A12563
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    BET degrader
    BETd-260 is a potent BET degrader based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line. 了解更多
  17. PROTAC Sirt2 Degrader-1
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    PROTAC Sirt2 Degrader-1

    Catalog No. A20005
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    Sirt2 degrader
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. 了解更多
  18. PROTAC BET degrader-2
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    PROTAC BET degrader-2

    Catalog No. A18785
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    PROTAC BET degrader
    PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. 了解更多
  19. dBET57
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    dBET57

    Catalog No. A19133
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    BRD4BD1degrader
    dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. 了解更多
  20. MZP-55
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    MZP-55

    Catalog No. A19415
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    BRD3/4 degrader
    MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. 了解更多
  21. MZP-54
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    MZP-54

    Catalog No. A19426
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    BRD3/4 degrader
    MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. 了解更多
  22. MZ1
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    MZ1

    Catalog No. A17014
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    BRD4 protein degrader
    MZ1是BRD2和BRD3上BRD4可逆，持久和选择性去除的有效诱导剂。 了解更多
  23. dBET1
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    dBET1

    Catalog No. A16858
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    BRD4 protein degrader
    dBET1是基于PROTAC技术的有效BRD4蛋白降解剂，EC50为430 nM。 了解更多

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