Topoisomerase

Catalog No.Inhibitor Name TopoisomeraseTopo ITopo IITopo IVOther
A10174Camptothecin
**
A10939Topotecan HCl
****
A10465Idarubicin HCl
***
Multicellular spheroids
A10194Daunorubicin HCl
***
A11999Betulinic acid
**
HIV-1,Aminopeptidase N
A11861Flumequine
*
A14403Doxorubicin
A10373Etoposide
A10478Irinotecan
A10345Epirubicin HCl
A10596Mitoxantrone HCl
A10609Moxifloxacin HCl
A10479Irinotecan HCl Trihydrate
A12011SN-38
A10071Amonafide
A10907Teniposide
A10419Gatifloxacin
A10426Genistein
EGFR
A10595Mitoxantrone
A10735Pirarubicin
A10041Adriamycin
A10557Marbofloxacin
A10666Ofloxacin
A10740Podophyllotoxin
A12663Amrubicin
A13059Beta-Lapachone
IDO1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 75个

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  1. Edotecarin

    Catalog No. A21233
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    Topoisomerase I inhibitor
    Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. 了解更多
  2. Karenitecin

    Catalog No. A21156
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    topoisomerase I inhibitor
    Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity. 了解更多
  3. Namitecan

    Catalog No. A21146
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    topoisomerase I inhibitor
    Namitecan is a potent topoisomerase I inhibitor, with antitumor property. 了解更多
  4. Gepotidacin

    Catalog No. A21086
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    topoisomerase II inhibitor
    Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. 了解更多
  5. Pirarubicin Hydrochloride

    Catalog No. A18037
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    topoisomerase II inhibitor
    Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. 了解更多
  6. Amsacrine hydrochloride

    Catalog No. A17707
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    antineoplastic agent
    Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. 了解更多
  7. 9-amino-CPT

    Catalog No. A12540
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    Topoisomerase I inhibitor
    9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity. 了解更多
  8. MAC glucuronide phenol-linked SN-38

    Catalog No. A18403
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    DNA topoisomerase I inhibitor
    MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. 了解更多
  9. CL2A-SN-38

    Catalog No. A18392
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    DNA Topoisomerase I inhibitor
    CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. 了解更多
  10. Epirubicin

    Catalog No. A12409
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    Topoisomerase 抑制剂
    Epirubicin是一种细胞可渗透的抗肿瘤抗生素。阿霉素的立体异构体,其心脏毒性降低。表柔比星的抗肿瘤作用是通过靶向和抑制Topo II(拓扑异构酶II)来介导的。 了解更多
  11. GENZ-644282

    Catalog No. A13206
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    topoisomerase 1 抑制剂
    GENZ-644282是拓扑异构酶I的非喜树碱抑制剂,具有潜在的抗肿瘤活性。 了解更多
  12. Beta-Lapachone

    Catalog No. A13059
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    DNA topoisomerase II 抑制剂
    Beta-Lapachone是一种选择性的DNA拓扑异构酶I抑制剂,对DNA拓扑异构酶II或连接酶没有抑制活性。 了解更多
  13. SN 38

    Catalog No. A12011
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    DNA topoisomerase 抑制剂
    SN 38是依立替康(喜树碱的类似物-拓扑异构酶I抑制剂)的活性代谢物。 了解更多
  14. Doxorubicin

    Catalog No. A14403
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    Topoisomerase II 抑制剂
    Doxorubicin是一种抑制DNA拓扑异构酶II并诱导DNA损伤和凋亡的抗生素。 了解更多
  15. Ellipticine

    Catalog No. A13780
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    DNA topoisomerase II 抑制剂
    Ellipticine是DNA嵌入剂和DNA拓扑异构酶II抑制剂。 了解更多
  16. NK314

    Catalog No. A13993
    Topoisomerase II 抑制剂
    NK314是一种新型的合成苯并[c]菲啶生物碱,具有很强的抗肿瘤活性。它抑制拓扑异构酶II活性并稳定拓扑异构酶II-DNA可裂解的复合物。 了解更多
  17. ABT 492 meglumine (Delafloxacin meglumine)

    Catalog No. A15064
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    ABT 492 meglumine (Delafloxacin meglumine)对喹诺酮敏感和耐药的革兰氏阳性生物更有力,对环丙沙星家族肠杆菌科的某些成员具有类似于环丙沙星的活性,对喹诺酮敏感,非发酵性,革兰氏阴性生物具有类似的活性。 了解更多
  18. (-)-Epigallocatechin gallate

    Catalog No. A10005
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    Antioxidant, antiangiogenic, antitumor agent
    (-)-Epigallocatechin gallate是一种从绿茶中分离出来的强效抗氧化剂多酚类黄酮。 了解更多
  19. Moxifloxacin HCl

    Catalog No. A10609
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    Topoisomerase 抑制剂
    Moxifloxacin HCl是一种喹诺酮/氟喹诺酮类抗菌剂。 了解更多
  20. TAS-103

    Catalog No. A21954
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    DNA topoisomerase I/II inhibitor
    TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. 了解更多
  21. Amonafide (AS1413)

    Catalog No. A10071
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    Topoisomerase 抑制剂
    Amonafide (AS1413)是一种DNA插入剂和拓扑异构酶II抑制剂,是治疗肿瘤疾病的抗肿瘤药物之一。 了解更多
  22. Daunorubicin

    Catalog No. A21903
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    topoisomerase II inhibitor
    Daunorubicin (Daunomycin; RP 13057; Rubidomycin) is a topoisomerase II inhibitor with potent antineoplastic activities. 了解更多
  23. Daun02

    Catalog No. A21818
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    prodrug of the topoisomerase inhibitor Daunorubicin
    Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. 了解更多
  24. Irinotecan

    Catalog No. A10478
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    Topoisomerase I 抑制剂
    Irinotecan通过抑制拓扑异构酶防止DNA解链。 了解更多
  25. Idarubicin HCl

    Catalog No. A10465
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    Topoisomerase 抑制剂
    Idarubicin HCl是蒽环类抗生素,是一种比柔红霉素具有更高DNA结合能力和更大细胞毒性的抗白血病药物。 了解更多
  26. Genistin (Genistoside)

    Catalog No. A10426
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    Genistin (Genistoside)是一种异黄酮,存在于许多饮食植物中,如大豆和葛根。显示出刺激体内雌激素依赖性乳腺癌细胞生长。 了解更多
  27. Etoposide (VP-16)

    Catalog No. A10373
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    Topoisomerase II 抑制剂
    Etoposide (VP-16)是通过抑制topoisomerase II活性而抑制DNA合成。 了解更多
  28. Dxd

    Catalog No. A21517
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    DNA topoisomerase I inhibitor
    Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). 了解更多
  29. Exatecan Mesylate

    Catalog No. A21515
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    DNA topoisomerase I inhibitor
    Exatecan Mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. 了解更多
  30. Voreloxin Hydrochloride

    Catalog No. A15280
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    Topoisomerase 抑制剂
    Voreloxin hydrochloride是一种小分子,是具有抗肿瘤活性的萘啶类似物;Topo II抑制剂。 了解更多
  31. Dexrazoxane

    Catalog No. A17714
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    topoisomerase IIα inhibitor
    Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. 了解更多
  32. Clorobiocin

    Catalog No. A15467
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    DNA Gyrase 抑制剂
    Clorobiocin是一种氨基香豆素。 了解更多
  33. Top1 inhibitor 1

    Catalog No. A13304
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    human topoisomerase I (Top1) inhibitor
    Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM. 了解更多
  34. SW044248

    Catalog No. A15837
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    TOP1 抑制剂?
    SW044248是一种新型的非规范性Top1抑制剂,对NSCLC细胞具有选择性毒性。 了解更多
  35. Rubitecan

    Catalog No. A22040
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    topoisomerase I inhibitor
    Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. 了解更多
  36. Teniposide

    Catalog No. A10907
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    Teniposide是鬼臼毒素的半合成衍生物,具有抗肿瘤活性。 了解更多
  37. Levofloxacin hydrate

    Catalog No. A16167
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    topoisomerase II IV 抑制剂
    Levofloxacin hydrate是广谱的第三代氟喹诺酮类抗生素,是具有抗菌活性的氧氟沙星的旋光性L-异构体。 了解更多
  38. Clinafloxacin

    Catalog No. A16458
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    DNA gyrase and topoisomerase IV 抑制剂
    Clinafloxacin是一种氟喹诺酮,可双重抑制肺炎链球菌中的DNA促旋酶和拓扑异构酶IV。 了解更多
  39. Zoliflodacin

    Catalog No. A22032
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    DNA gyrase/topoisomerase inhibitor
    Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. 了解更多
  40. Intoplicine

    Catalog No. A20104
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    DNA topoisomerase I/II inhibitor
    Intoplicine is a DNA topoisomerase I and II inhibitor. 了解更多
  41. Indotecan

    Catalog No. A20979
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    Top1 inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. 了解更多
  42. Pixantrone

    Catalog No. A13022
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    Topoisomerase II 抑制剂
    Pixantrone是一种拓扑异构酶II抑制剂和DNA嵌入剂,具有抗肿瘤活性。 了解更多
  43. Topotecan

    Catalog No. A16815
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    Topoisomerase 抑制剂
    Topotecan是用于治疗卵巢癌的抗肿瘤药,可通过抑制DNA拓扑异构酶起作用。 了解更多
  44. MAC glucuronide α-hydroxy lactone-linked SN-38

    Catalog No. A18407
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    Topoisomerase I inhibitor
    MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. 了解更多
  45. CL2-SN-38

    Catalog No. A18945
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    DNA topoisomerase I inhibitor
    CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. 了解更多
  46. Norfloxacin (Norxacin)

    Catalog No. A10652
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    Topoisomerase 抑制剂
    Norfloxacin(Norxacin)是一种广谱抗生素。 了解更多
  47. Marbofloxacin

    Catalog No. A10557
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    Topoisomerase 抑制剂
    Marbofloxacin是有效的第三代氟喹诺酮类抗生素,通过抑制细菌DNA复制起作用。 了解更多
  48. Topotecan HCl (Hycamtin)

    Catalog No. A10939
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    DNA topoisomerase I 抑制剂
    Topotecan HCl (Hycamtin)是一种化学治疗剂,是拓扑异构酶抑制剂。 了解更多
  49. Irinotecan HCl Trihydrate (Campto)

    Catalog No. A10479
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    Topoisomerase 抑制剂
    Irinotecan (CPT 11)是喜树碱家族的一种化合物,是参与细胞DNA复制和转录的拓扑异构酶1的抑制剂。 了解更多
  50. ABT-492 (Delafloxacin)

    Catalog No. A10023
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    Fluoroquinolone antibiotic
    ABT-492 (Delafloxacin)是一种新的氟喹诺酮类药物,可抵抗155种需氧和171种厌氧菌。 了解更多

产品 1 到 50 共 75个

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