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ACP-196 (Acalabrutinib)
Catalog No. A15824 Btk 抑制剂ACP-196是Bruton酪氨酸激酶（BTK）抑制剂，具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体（BCR）信号传导途径的激活。 了解更多 -
Fiacitabine
Catalog No. A11422 HSV DNA replication 抑制剂Fiacitabine是单纯疱疹病毒(HSV)DNA复制的选择性抑制剂，HSV1和HSV2的IC50值分别为2.5 nM和12.6 nM。 了解更多 -
Napabucasin
Catalog No. A13474 -
NVP-BAW2881
Catalog No. A12693 VEGFR 抑制剂NVP-BAW2881是有效的选择性VEGFR抑制剂（血管内皮生长因子受体酪氨酸激酶抑制剂），IC50 为值9 nM，具有抑制慢性和急性皮肤炎症的作用。 了解更多 -
GZD824 Dimesylate
Catalog No. A15849 Bcr-Abl 抑制剂GZD824 Dimesylate是Bcr-Abl（WT）和Bcr-Abl（T315I）的新型生物可用Bcr-Abl抑制剂，IC50分别为0.34 nM和0.68 nM。 了解更多 -
Abametapir
Catalog No. A15945 metalloproteinase 抑制剂ABAMETAPIR是Xeglyze乳液的活性成分。ABAMETAPIR抑制金属蛋白酶；对卵子发育，若虫和成年虱子存活至关重要的生理过程必不可少的酶。 了解更多 -
MLN1117 (Serabelisib)
Catalog No. A15529 p110α 抑制剂MLN1117，也称为INK1117和TAK-117，是具有潜在抗肿瘤活性的I类磷酸肌醇3激酶（PI3K）α同工型的生物利用抑制剂。 了解更多 -
WWL70
Catalog No. A15994 -
GSK744 (S/GSK1265744)
Catalog No. A16014 HIV integrase 抑制剂GSK744 (S/GSK1265744)是一种有效的HIV整合酶抑制剂，可作为口服导入片剂和长效注射剂，用于治疗和预防HIV感染。 了解更多 -
Butabindide oxalate
Catalog No. A16029 -
Tiagabine hydrochloride
Catalog No. A16135 -
Flumatinib
Catalog No. A16258 multi-kinase 抑制剂Flumatinib是一种多激酶抑制剂，对c-Abl，PDGFRbeta和c-Kit的IC50值分别为1.2 nM，307.6 nM和2662 nM。 了解更多 -
GZD824
Catalog No. A16264 -
Lyn-IN-1
Catalog No. A16265 -
WEHI-539 hydrochloride
Catalog No. A13327 -
AN3365
Catalog No. A16329 -
LY2835219 methanesulfonate
Catalog No. A16386 -
Talabostat mesylate
Catalog No. A14080 -
Avitinib (AC0010)
Catalog No. A16826 irreversible EGFR 抑制剂Avitinib (AC0010)是一种基于吡咯并嘧啶的不可逆EGFR抑制剂，对EGFR L858R/T790M双重突变具有突变选择性，IC50值为0.18 nM，效力比野生型EGFR（IC50值为7.68 nM）高近43倍。它具有可比的抗肿瘤活性和耐受的毒性。 了解更多 -
ABBV-744
Catalog No. A16831 -
Glecaprevir
Catalog No. A16948 HCV NS3/4A protease 抑制剂Glecaprevir，也称为ABT-493和A-1282576，是一种新型的HCV NS3/4A蛋白酶抑制剂，IC50值在3.5至11.3 nM之间。 了解更多 -
ABX-464
Catalog No. A16912 -
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YHO-13177
Catalog No. A17127 -
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Vecabrutinib
Catalog No. A17189 -
CMP3a
Catalog No. A18347 NEK2 kinase inhibitorCMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. 了解更多 -
Ethopabate
Catalog No. A17296 folate metabolism inhibitorEthopabate is a folate metabolism inhibitor used in the prophylaxis and treatment of coccidiosis in chickens. 了解更多 -
AX-024 hydrochloride
Catalog No. A18332 TNF receptor inhibitorAX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases. 了解更多 -
PF-6260933
Catalog No. A18326 MAP4K4 inhibitorPF-06260933 is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM. 了解更多 -
JNJ-38877618
Catalog No. A18325 c-Met inhibitorJNJ-38877618 is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. 了解更多 -
Abrocitinib (PF-04965842)
Catalog No. A18318 JAK1 抑制剂Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease. 了解更多 -
Upadacitinib (ABT-494)
Catalog No. A18316 JAK-1 抑制剂Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM. IC50 & Target: IC50: 43 nM (JAK1), 200 nM (JAK2) 了解更多 -
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最新产品
SAR-7334 HCl
Catalog No. A17237 TRPC6 inhibitorSAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多 -
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最新产品
KC01
Catalog No. A17229 -
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最新产品
Mivebresib (ABBV-075)
Catalog No. A17226 BET inhibitorMivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. 了解更多 -
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WEHI-9625
Catalog No. A18351 tricyclic sulfone inhibitorWEHI-9625 is a tricyclic sulfone small molecule inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK, but is completely inactive against both human BAK and the closely related apoptosis effector BAX. 了解更多 -
Rabeprazole
Catalog No. A17437 H(+)-K(+)-exchanging ATPase inhibitorRabeprazole is an inhibitor of H(+)-K(+)-exchanging atpase in gastric parietal cells. 了解更多
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