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搜索结果：“jwh 250”

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Mercaptopurine

Catalog No. A10568
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Mercaptopurine已显示出干扰DNA和RNA合成并引起从头嘌呤合成的抑制。了解更多

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Meropenem

Catalog No. A10569
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Meropenem是碳青霉烯亚类的β-内酰胺抗生素，已显示抑制青霉素酶阴性，阳性和对甲氧西林敏感的葡萄球菌。了解更多

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Heidi Kaech, .et al. Similar cost of Hamiltonella defensa in experimental and natural aphid-endosymbiont associations, Ecol Evol, 2022, Jan 24;12(1):e8551 PMID: 35127049
- Sreevalli Sharma, .et al. Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria, ACS Infect Dis, 2021, Nov 12;7(11):3009-3024 PMID: 34699190
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Mestranol

Catalog No. A10572
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Mestranol是炔雌醇的3-甲基醚。它是许多最初的口服避孕药中使用的雌激素。了解更多

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Methscopolamine bromide

Catalog No. A10579
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Methscopolamine bromide是一种竞争性抗毒蕈碱剂，可阻断乙酰胆碱与毒蕈碱型乙酰胆碱受体（mAChR M）的结合。了解更多

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Methylprednisolone

Catalog No. A10582
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Methylprednisolone是一种凋亡诱导剂，并且在体外也能抑制人小细胞肺癌细胞的生长。了解更多

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Mianserin hydrochloride

Catalog No. A10588
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5-HT2/5-HT1 拮抗剂

Mianserin hydrochloride是5-HT2/5-HT1拮抗剂。对5-HT6非选择性5-HT2受体拮抗剂具有中等亲和力。对5-HT6具有中等亲和力。了解更多

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Mifepristone (Mifeprex)

Catalog No. A10591
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Mifepristone (Mifeprex)是一种抗氧化剂和糖皮质激素受体拮抗剂，具有抑制NFκB活化的能力，NFκB是一种影响各种粘附分子和几种炎症基因表达的核转录因子。了解更多

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- Shuang Liang, .et al. Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b, Cardiovasc Ther, 2022, Apr 7;2022:7145699 PMID: 35474714
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Milrinone (Primacor)

Catalog No. A10592
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PDE3 抑制剂

Milrinone (Primacor)是一种有效的选择性磷酸二酯酶3抑制剂，IC50为0.42μM，可抑制FIII PDE。了解更多

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Mitotane

Catalog No. A10594
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Mitotane (Lysodren)是用于治疗肾上腺皮质癌的抗肿瘤药。了解更多

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Mitoxantrone Hydrochloride

Catalog No. A10596
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Mitoxantrone Dihydrochloride是一种抗病毒，抗菌，抗原生动物，免疫调节和抗肿瘤细胞抑制性蒽醌衍生物。了解更多

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Mycophenolic acid

Catalog No. A10614
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Mycophenolic Acid是一种免疫抑制剂小分子，是从几种青霉菌中分离出来的发酵产物。了解更多

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- Romana Vrzonova, .et al. OCT1 - a yeast mitochondrial thiolase involved in the 3-oxoadipate pathway, FEMS Yeast Res, 2021, Jun 29;21(5):foab034 PMID: 34089318
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Naftopidil (Flivas)

Catalog No. A10618
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Naftopidil (Flivas)是选择性的α1-肾上腺素能受体拮抗剂或α受体阻滞剂，Ki为58.3 nM。了解更多

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Phenoxybenzamine hydrochloride

Catalog No. A10719
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α-adrenergic (AR) 拮抗剂/CaM 抑制剂

Phenoxybenzamine hydrochloride是一种细胞可渗透的，非特异性的，不可逆的α-肾上腺素（AR）拮抗剂，也可作为CaM抑制剂。了解更多

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Phenytoin (Lepitoin)

Catalog No. A10721
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Phenytoin (Lepitoin)是钠通道蛋白抑制剂。了解更多

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Phenytoin sodium (Dilantin)

Catalog No. A10722
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Phenytoin sodium (Dilantin)是一种钠通道蛋白抑制剂。了解更多

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Pizotifen malate

Catalog No. A10738
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Pizotifen malate是苯并环庚噻吩的衍生物，是一种三环化合物，被发现是有效的SR-2受体活性抑制剂。了解更多

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Prednisone (Adasone)

Catalog No. A10752
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Glucocorticoid Receptor 激动剂

Prednisone (Adasone)可降低粘膜TNF-a的产生，肠道通透性和NF-kB表达水平。了解更多

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Terbinafine hydrochloride (Lamisil)

Catalog No. A10912
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Terbinafine hydrochloride (Lamisil)是烯丙胺类抗真菌药的一种，是通过角鲨烯环氧酶抑制作用合成麦角固醇的特异性抑制剂。了解更多

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Carvedilol

Catalog No. A11843
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β2-adrenergic receptor

Carvedilol是具有抗氧化特性的β1和β2肾上腺素能受体（AR）激动剂。了解更多

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Azacyclonol

Catalog No. A11806
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Azacyclonol，也称为γ-pipradol，是一种用于减少精神病患者幻觉的药物。了解更多

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Adrenalone HCl

Catalog No. A11807
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adrenergic 激动剂

Adrenalone HCl是一种肾上腺素能激动剂，用作局部血管收缩药和止血药，主要作用于α-1肾上腺素能受体。了解更多

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Azithromycin (Zithromax)

Catalog No. A11803
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Azithromycin (Zithromax)是一种氮杂内酯类抗生素，可抑制革兰氏阴性细菌（如流感嗜血杆菌）的生长。了解更多

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- T Azuma ,etc. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents. Science of The Total Environment, 2016, 548-549:189-97..
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Amidopyrine

Catalog No. A11805
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Amidopyrine是白色结晶物质，用作镇痛药和解热药。了解更多

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Nadifloxacin

Catalog No. A11894
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Nadifloxacin是一种细胞可渗透的，合成的广谱氟喹诺酮类抗生素，可抑制革兰氏阳性和革兰氏阴性菌的生长。了解更多

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Levosimendan

Catalog No. A11874
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Levosimendan是一种Ca2+敏化剂，通过与cardiac troponin C (cTnC)结合而发挥作用，这种作用具有钙依赖性。了解更多

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Ascomycin

Catalog No. A12592
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calcineurin 抑制剂

Ascomycin是一种有效的免疫抑制剂，可用作自身免疫性疾病的潜在治疗剂。了解更多

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(+)-Bicuculline

Catalog No. A12590
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GABAA 拮抗剂

(+)-Bicuculline是一种经典的GABAA拮抗剂。了解更多

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- Maryam Adenike Salaudeen, .et al. Anticonvulsant Activity of Tapinanthus dodoneifolius (DC.) Danser in Chicks and Mice: A Potential Source of Novel Anticonvulsant Agent, J Pharmacy and Drug Innovations, 2022, 3(4)
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Articaine HCl

Catalog No. A11808
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Articaine HCl是一种牙科局部麻醉剂，含有一个附加的酯基，该酯基可以被血液和组织中的酯酶代谢掉。了解更多

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Altrenogest

Catalog No. A11809
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Altrenogest是与兽医类固醇群勃龙在结构上相关的孕激素。了解更多

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NMDA

Catalog No. A12751
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NMDA receptor 激动剂

NMDA是一种原型NMDA受体激动剂。了解更多

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Ouabain

Catalog No. A12755
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a-K-ATPase 抑制剂

Ouabain是一种选择性的Na+，K+-ATPase抑制剂。了解更多

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- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
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Regorafenib (BAY 73-4506)

Catalog No. A10250
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VEGFR 抑制剂

Regorafenib (BAY 73-4506)是一种多激酶抑制剂，IC50为17、40和69 nM c-KIT，VEGFR2，B-Raf。Regorafenib（BAY 73-4506）是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。了解更多

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- Paula Sagmeister, .et al. Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis, J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
- Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
- Jindal A, .et al. Milciclib and sorafenib synergistically downregulate c-Myc to suppress tumor growth in an orthotopic murine model of human hepatocellular carcinoma, J Transl Sci, 2020, 7: 1-10
- Makoto Koyama, .et al. Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells, Int J Oncol, 2020, Sep 2 PMID: 32901840
- Mariko Fujisawa, .et al. Involvement of the Interferon Signaling Pathways in Pancreatic Cancer Cells, Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774
- Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298
- Sunil Kumar Yadava, .et al. Low Temperature, Easy Scaling Up Method for Development of Smart Nanostructure Hybrid Lipid Capsules for Drug Delivery Application, Colloids Surf B Biointerfaces, 2020, Mar 2;190:110927 PMID: 32169777
- Takeshi Uenaka, .et al. In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease, Hum Mol Genet, 2018, Nov 15; 27(22): 3974-3985 PMID: 30137437
- Yi Xu, .et al. Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2, Free Radic Biol Med, 2016, Jul; 96: 67-77 PMID: 27101738
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ABT-263 (Navitoclax)

Catalog No. A10022
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Bcl-2 抑制剂

ABT-263 (Navitoclax)是一种有效的Bcl-2家族抑制剂 (Bcl-2，Bcl-xL和Bcl-w的Ki <1 nmol/L)。ABT-263对Bcl- xL，Bcl-2和Bcl-w，( Ki≤1nmol/ L) 维持高亲和力，但与Mcl-1和A1的结合更弱。了解更多

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- Rindert Missiaen, .et al. GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment, Cell Metab, 2022, Aug 2;34(8):1151-1167 PMID: 35839757
- Ashlyn Parkhurst, .et al. Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors, Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114
- Suzuki, Keiji, .et al. Characterization of radiation-induced micronuclei associated with premature senescence, and their selective removal by senolytic drug, ABT-263, Mutat Res Genet Toxicol Environ Mutagen, 2022, 876-877. 503448
- Rotem Ben-Hamo, .et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers, Nat Commun, 2020, 11: 3296
- Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
- Hiroki Akiyama, .et al. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically With BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells, Cancers, 2020, 12 (2) PMID: 32050632
- Stephanie Ketterer, .et al. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling, Nat Commun, 2020, Oct 12;11(1):5133 PMID: 33046706
- Makoto Koyama, .et al. Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells, Int J Oncol, 2020, Sep 2 PMID: 32901840
- Min Li, .et al. Clearance of HIV infection by selective elimination of host cells capable of producing HIV, Nat Commun, 2020, 11: 4051 PMID: 32792548
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
- Anderson R, .et al. Length-independent telomere damage drives postmitotic cardiomyocyte senescence, EMBO J, 2019, Feb 8. pii: e100492 PMID: 30737259
- Shinya Ishida, .et al. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2, Oncotarget, 2018, Jun 1; 9(42): 26834-26851 PMID: 29928488
- Rhys Anderson, .et al. Length-independent telomere damage drives cardiomyocyte senescence, bioRxiv, 2018, 2018
- Ryuta Mikawa, .et al. Elimination of p19ARF?\expressing cells protects against pulmonary emphysema in mice, Aging Cell, 2018, Oct; 17(5): e12827 PMID: 30058137
- Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327
- Toshiyuki Sumi, .et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609
- Wei TW, .et al. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA, Cancer Res, 2017, Jan 15;77(2):494-508 PMID: 28069801
- Yusuke Takagi, .et al. SPIB is a novel prognostic factor in diffuse large B?\cell lymphoma that mediates apoptosis via the PI3K-AKT pathway, Cancer Sci, 2016, Sep; 107(9): 1270-1280 PMID: 27348272
- Matsumoto M, .et al. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells, Biochem Biophys Res Commun, 2016, Apr 29;473(2):490-6 PMID: 26996126
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MLN9708

Catalog No. A10602
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Proteasome 抑制剂

MLN9708是一种蛋白酶体抑制剂，可抑制蛋白酶体的活性，从而阻断通常由蛋白酶体进行的靶向蛋白水解。了解更多

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Temsirolimus (Torisel)

Catalog No. A10906
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mTOR 抑制剂

Temsirolimus (Torisel)是mTOR的特异性抑制剂，会干扰调节肿瘤细胞增殖，生长和存活的蛋白质的合成。了解更多

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AZD8931 (Sapitinib)

Catalog No. A10116
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pan-EGFR/pan-erbB 抑制剂

AZD8931 (Sapitinib)是ErbB1，ErbB2和ErbB3受体信号传导的等效抑制剂。了解更多

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- Takeshi Ito, .et al. Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification, Biochem Biophys Res Commun, 2019, in Press
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17-AAG (KOS953)

Catalog No. A10010
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HSP90 抑制剂

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。了解更多

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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
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TGX-221

Catalog No. A10923
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PI3K 抑制剂

TGX-221是PI3Kp110β的有效，选择性和细胞渗透性抑制剂。了解更多

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- Mostafa Khater, .et al. Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK, J Biol Chem, 2021, Jan-Jun, 296:100805 PMID: 34022220
- Mostafa Khater, .et al. G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers, J Biol Chem, 2021, Jan 22;296:100325 PMID: 33493514
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
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AG-1478 (Tyrphostin AG-1478)

Catalog No. A11022
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EGFR 抑制剂

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。了解更多

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- Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
- Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733
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SGI-1776 (free base)

Catalog No. A10838
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PIM1 抑制剂

SGI-1776 (free base)是Pim1的一种新型ATP竞争性抑制剂，在无细胞试验中的IC50为7 nM，选择性是Pim2和Pim3的50倍和10倍，对Flt3和haspin也有效。阶段1。了解更多

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- Ishikawa C, .et al. Expression and significance of Pim-3 kinase in adult T-cell leukemia, Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639
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VX-765 (Belnacasan)

Catalog No. A10984
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Caspase-1/4 抑制剂

VX-765 (Belnacasan)是一种新型的Caspase-1抑制剂，是一种控制两种细胞因子IL-1b和IL-18生成的酶。了解更多

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- Arjun Thapa, .et al. Danger-associated molecular pattern molecules take unexpectedly a central stage in Nlrp3 inflammasome-caspase-1-mediated trafficking of hematopoietic stem/progenitor cells, Leukemia, 2021, 23 February
- Prenitha Mercy Ignatius Arokia Doss, .et al. Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity, Cell Rep, 2021, Mar 9;34(10):108833 PMID: 33691111
- Joseph Flores, .et al. Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging, Nat Commun, 2020, Sep 11;11(1):4571 PMID: 32917871
- Joseph Flores, .et al. Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model, Nat Commun, 2018, 9: 3916 PMID: 30254377
- Mohamed F. Ali, .et al. Canonical Stimulation of the NLRP3 Inflammasome by Fungal Antigens Links Innate and Adaptive B-Lymphocyte Responses by Modulating IL-1β and IgM Production, Front Immunol, 2017, 8: 1504 PMID: 29170665
- García-Fernández A, .et al. Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles, J Control Release, 2017, Feb 28;248:60-70 PMID: 28069553
- Jiujiu Yu, .et al. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy, Proc Natl Acad Sci U S A, 2014, 111(43): 15514-15519 PMID: 25313054
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ICG-001

Catalog No. A11039
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Wnt/beta-catenin 抑制剂

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。了解更多

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- Seonmin Choi, .et al. Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors, Yonsei Med J, 2021, Nov;62(11):1042-1051 PMID: 34672138
- Jasper C.Munro, .et al. Cardiac function and feed efficiency: increased right-heart workload in feed inefficient beef cattle, Livest Sci, 2019, 229 (2019) 159-169
- Kim JH, .et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus, Cell Rep, 2019, May 14;27(7):2105-2118.e5 PMID: 31091449
- Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
- Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536
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SNS-032 (BMS-387032)

Catalog No. A10850
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CDK 抑制剂

SNS-032（BMS-387032）是细胞周期蛋白依赖性激酶（Cdks）2、7和9的高度选择性和有效抑制剂，具有体外生长抑制作用，并具有诱导恶性B细胞凋亡的能力。了解更多

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LY2228820 (Ralimetinib)

Catalog No. A10545
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p38 MAPK 抑制剂

LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。了解更多

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Agomelatine

Catalog No. A10048
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5-HT Receptor 拮抗剂

Agomelatine是一种褪黑素激动剂（MT1和MT2受体）和5-HT2C拮抗剂。了解更多

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OSI-906

Catalog No. A11053
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IGF-1R 抑制剂

OSI-906是一种选择性IGF-1R抑制剂，在无细胞试验中IC50为35 nM；对InsR抑制作用适中，IC50为75 nM，对Abl，ALK，BTK，EGFR， FGFR1/2，PKA等没有抑制活性。了解更多

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- Masao Kakoki, .et al. Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling, Communications Biology, 2021, 4:775
- Nakamura T, .et al. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production, J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
- Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Takata N, .et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358
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Topotecan HCl (Hycamtin)

Catalog No. A10939
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DNA topoisomerase I 抑制剂

Topotecan HCl (Hycamtin)是一种化学治疗剂，是拓扑异构酶抑制剂。了解更多

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TW-37

Catalog No. A10955
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Bcl-2 抑制剂

TW-37是Bcl-2的小分子抑制剂，可抑制胰腺癌细胞的生长，并通过一种涉及Notch-1和Jagged-1失活的新途径介导的胰腺癌细胞凋亡。了解更多

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S/GSK1349572 (Dolutegravir)

Catalog No. A11068
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HIV integrase 抑制剂

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。了解更多

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- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
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MK-0752

Catalog No. A11194
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Gamma-secretase 抑制剂

MK-0752抑制Notch信号通路，这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。了解更多

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