NF-kB/IkB

产品 51 到 100 共 131个

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  1. CI994 (Tacedinaline)

    Catalog No. A11964
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    HDAC 抑制剂
    CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶(HDAC)抑制剂,可在活细胞中诱导组蛋白超乙酰化。 了解更多
  2. Romidepsin (FK228 ,Depsipeptide)

    Catalog No. A11920
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    HDAC 抑制剂
    Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2,IC50分别为1.6 nM和3.9 nM,但相对较弱地分别抑制HDAC4和HDAC6,IC50值为25 nM和79 nM。 了解更多
  3. Apicidin

    Catalog No. A12745
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    HDAC 抑制剂
    Apicidin是一种有效的组蛋白脱乙酰基酶(HDAC)抑制剂,具有潜在的抗癌活性。 了解更多
  4. RGFP966

    Catalog No. A13218
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    HDAC3 抑制剂
    RGFP966是一种HDAC3抑制剂,IC50为0.08μM,与其他HDAC相比,具有> 200倍的选择性。 了解更多
  5. BRD9757

    Catalog No. A12911
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    HDAC6 抑制剂
    BRD9757是一种高效且选择性的HDAC6抑制剂,对HDAC6的IC50为30 nM。 了解更多
  6. Resminostat

    Catalog No. A12556
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    HDAC 抑制剂
    Resminostat,也称为RAS2410,是一种有效的I和II类组蛋白脱乙酰基酶(HDAC)抑制剂。它结合并抑制HDAC,从而导致高度乙酰化的组蛋白的积累。选择性的抑制HDAC1/3/6,IC50为42.5 nM/50.1 nM/71.8 nM,作用于HDAC8效果弱,IC50为877 nM。 了解更多
  7. Scriptaid

    Catalog No. A12722
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    HDAC 抑制剂
    Scriptaid是一种HDAC抑制剂(组蛋白脱乙酰基酶)。 了解更多
  8. TMP 269

    Catalog No. A14128
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    HDAC 抑制剂
    TMP 269是一种有效的选择性IIa类HDAC抑制剂,对HDAC4,HDAC5,HDAC7和HDAC9的IC50分别为157 nM,97 nM,43 nM和23 nM。 了解更多
  9. RG2833 (RGFP109)

    Catalog No. A13139
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    HDAC 抑制剂
    RG2833 (RGFP109)是一种脑渗透性HDAC抑制剂,IC50为60 nM,HDAC1和HDAC3为50 nM。 了解更多
  10. BRD73954

    Catalog No. A15489
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    HDAC 抑制剂
    BRD73954是一种小分子抑制剂,可有效抑制HDAC6和HDAC8(IC50分别为36和120 nM)。 了解更多
  11. Resminostat hydrochloride

    Catalog No. A15220
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    HDAC 抑制剂
    Resminostat hydrochloride是HDAC1/3/6的有效抑制剂(IC50 = 43-72 nM);对HDAC8的效力较低,IC50为877 nM。 了解更多
  12. KD 5170

    Catalog No. A15354
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    HDAC 抑制剂
    KD 5170是一种新型的基于巯基酮的组蛋白脱乙酰基酶抑制剂,在体外和体内均表现出广谱的抗肿瘤活性。 了解更多
  13. NCH 51

    Catalog No. A15355
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    HDAC 抑制剂
    NCH 51是细胞可渗透的前药,可在细胞内转化为有效的HDAC抑制剂,IC50为48 nM。 了解更多
  14. NSC 3852

    Catalog No. A15356
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    HDAC 抑制剂
    NSC 3852是HDAC(组蛋白脱乙酰基酶)抑制剂。 了解更多
  15. TC-H 106

    Catalog No. A15357
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    HDAC 抑制剂
    TC-H 106是一种慢速,紧密结合的I类HDAC(组蛋白脱乙酰基酶)抑制剂。 了解更多
  16. TCS HDAC6 20b

    Catalog No. A15387
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    HDAC6 抑制剂
    TCS HDAC6 20b是组蛋白脱乙酰基酶6(HDAC6)的选择性抑制剂。与紫杉醇联合抑制HCT116的生长。还抑制雌激素刺激的MCF-7细胞的生长。 了解更多
  17. R306465

    Catalog No. A15437
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    HDAC 抑制剂
    R306465是一种新型的基于异羟肟酸酯的组蛋白脱乙酰基酶(HDAC)抑制剂,在临床前模型中具有针对实体和血液恶性肿瘤的广谱抗肿瘤活性。 了解更多
  18. Citarinostat (ACY-241)

    Catalog No. A12758
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    HDAC6 抑制剂
    ACY-241是HDAC6的新型,选择性和口服抑制剂。对HDAC6和HDAC3的IC50分别为2.6 nM和46 nM。 了解更多
  19. ACY-738

    Catalog No. A15934
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    HDAC6 抑制剂
    ACY-738是一种有效的选择性HDAC6抑制剂,具有改善的脑生物利用度。ACY-738抑制HDAC6的纳摩尔浓度低,选择性比I类HDAC高60到1500倍。 了解更多
  20. BML-210

    Catalog No. A15935
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    HDAC 抑制剂?
    BML-210是HDAC抑制剂。BML-210诱导宫颈癌细胞中的生长抑制和凋亡并调节HDAC和DAPC复合物的表达水平。 了解更多
  21. M344

    Catalog No. A11355
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    HDAC 抑制剂
    M344是HDAC的有效抑制剂,IC50为100 nM,能够诱导细胞分化。 了解更多
  22. BG45

    Catalog No. A11361
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    HDAC 抑制剂
    BG45是一种HDAC I类抑制剂,对HDAC3具有选择性(IC50 = 289 nM)。它抑制HDAC1,HDAC2和HDAC6的效力大大降低(IC50分别为2、2和> 20μM)。 了解更多
  23. ITSA-1

    Catalog No. A16127
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    HDAC 抑制剂
    ITSA-1具有膜渗透性,可以特异性抑制TSA对HDAC(组蛋白脱乙酰基酶)的抑制,但不能抑制其他HDAC抑制剂。 了解更多
  24. CAY10603

    Catalog No. A16431
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    HDAC6 抑制剂
    CAY10603是一种有效的选择性HDAC6抑制剂,IC50为2 pM,选择性是其他HDAC的200倍以上。 了解更多
  25. CRA-026440

    Catalog No. A12179
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    HDAC inhibitor
    CRA-026440 is a potent, broad-spectrum HDAC inhibitor. 了解更多
  26. Valproic acid sodium salt

    Catalog No. A10855
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    HDAC inhibitor
    Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. 了解更多
  27. JAK/HDAC-IN-1

    Catalog No. A13362
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    JAK2/HDAC dual inhibitor
    JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. 了解更多
  28. Sodium phenylbutyrate

    Catalog No. A16714
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    HDAC/ER stress inhibitor
    Sodium phenylbutyrate is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. 了解更多
  29. Tubastatin A

    Catalog No. A16770
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    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). 了解更多
  30. CG-200745

    Catalog No. A20939
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    HDAC inhibitor
    CG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. 了解更多
  31. Givinostat

    Catalog No. A21126
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    HDAC inhibitor
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. 了解更多
  32. HDAC-IN-7

    Catalog No. A21252
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    HDAC1/2/3/10 inhibitor
    HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. 了解更多
  33. Givinostat hydrochloride

    Catalog No. A21487
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    HDAC inhibitor
    Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. 了解更多
  34. Nanatinostat

    Catalog No. A21625
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    HDAC inhibitor
    Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. 了解更多
  35. Belinostat

    Catalog No. A21772
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    HDAC inhibitor
    Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. 了解更多
  36. HDAC-IN-5

    Catalog No. A20972
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    HDAC inhibitor
    HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. 了解更多
  37. Domatinostat tosylate

    Catalog No. A20986
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    HDAC1 inhibitor
    Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 了解更多
  38. BX-795

    Catalog No. A11148
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    PDK-1 抑制剂
    BX-795是有效的PDK1抑制剂,可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。 了解更多
  39. Bay 11-7821

    Catalog No. A11957
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    E2 ubiquitin conjugating enzyme 抑制剂
    Bay 11-7821是TNF-α刺激的IκBα磷酸化的不可逆抑制剂。 了解更多
  40. SC-514

    Catalog No. A12746
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    IκB/IKK 抑制剂
    SC-514是一种具有口服活性的,具有ATP竞争性的IKKβ抑制剂(IC50 = 3-12μM),其选择性是JNK,p38,MK2和ERK等28种其他激酶的10倍以上。 了解更多
  41. IKK-16

    Catalog No. A12836
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    IKK 抑制剂
    IKK 16是针对IKK-2,IKK复合物和IKK-1的选择性IκB激酶(IKK)抑制剂,IC50分别为40 nM,70 nM和200 nM。 了解更多
  42. IMD 0354

    Catalog No. A12837
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    IKK 抑制剂
    IMD 0354是IκB激酶-β(IKKβ)抑制剂,可阻断NF-κB核易位。 了解更多
  43. PHA 408

    Catalog No. A13108
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    IKK-2 抑制剂
    PHA 408是一种有效的,高度选择性的,具有ATP竞争性的IKB激酶2(IKK-2)抑制剂(IC50:40 nM),它以相对较慢的释放速率紧密结合IKK-2。 强烈推荐您研究IKK-2调节NF-KB信号传导机制的工具。 了解更多
  44. TPCA-1

    Catalog No. A11579
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  45. WS3

    Catalog No. A12952
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    EBP1 抑制剂
    WS3是通过调节Erb3结合蛋白1(EBP1)和IκB激酶途径的β细胞增殖诱导剂。 了解更多
  46. WS6

    Catalog No. A12953
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    EBP1 抑制剂
    WS6是通过调节Erb3结合蛋白1(EBP1)和IκB激酶途径的β细胞增殖诱导剂。 了解更多
  47. BAY 11-7085

    Catalog No. A12470
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    κB/IKK 抑制剂
    BAY 11-7085是TNFα诱导的IκBα磷酸化的不可逆抑制剂,IC50为10μM。 了解更多
  48. BMS-345541

    Catalog No. A12559
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    IKK2/IKK1 抑制剂
    BMS-345541是IKK-2和IKK-1催化亚基的高度选择性抑制剂,IC50为0.3 μM和4 μM。 了解更多
  49. BI605906

    Catalog No. A13537
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    IKKβ 抑制剂
    BI605906是IKK beta的新型抑制剂。 了解更多
  50. PS-1145

    Catalog No. A12789
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    IKK 抑制剂
    PS-1145是一种高度特异性的IKB激酶(IKK)抑制剂,可有效抑制PC细胞的基础和诱导型NF-kB活性。 了解更多

产品 51 到 100 共 131个

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