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30 个项目
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GDC-0575 dihydrochloride
Catalog No. A21567 CHK1 inhibitorGDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. 了解更多 -
GDC-0575 (ARRY-575, RG7741)
Catalog No. A16811 -
GDC-0032 (Taselisib)
Catalog No. A12831 -
GDC-0834 Racemate
Catalog No. A12706 -
GDC-0879
Catalog No. A10420 -
GDC-0980 (Apitolisib, RG7422)
Catalog No. A11023 mTOR/PI3K 抑制剂GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。 了解更多 -
GDC-0941 (Pictilisib)
Catalog No. A10421 PI3K 抑制剂GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂，p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。 了解更多 -
GDC-0834
Catalog No. A21243 -
GDC-0068 (Ipatasertib, RG-7440)
Catalog No. A11246 Akt 抑制剂GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3的IC50值分别为5、18和8 nM。 了解更多 -
GDC-0973 (Cobimetinib)
Catalog No. A11441 MEK1 抑制剂GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂，IC50为4.2 nM，对MEK1的选择性选择性是对MEK2的100倍以上，并且当针对一组超过100个丝氨酸的抑制剂进行测试时，没有显示出明显的抑制作用。 了解更多 -
Pictilisib dimethanesulfonate
Catalog No. A11444 PI3Kα/δ inhibitorPictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). 了解更多 -
GDC0994 (Ravoxertinib)
Catalog No. A13420 ERK1/2 抑制剂GDC-0994是一种强效选择性Erk1/2抑制剂。GDC-0994抑制ERK磷酸化和ERK介导的信号转导通路的激活。 了解更多 -
GF 109203X
Catalog No. A13197 PKC 抑制剂GF 109203X是一种有效且选择性的蛋白激酶C抑制剂，对α和β1亚型具有选择性（对于α，β1，δ，δ，ε和ζ亚型，IC50分别为0.0084、0.0180、0.210、0.132和5.8μM）。对MLCK，PKG和PKA具有选择性（IC50值分别为0.6、4.6和33μM）。5-HT3受体的强效拮抗剂（Ki = 29.5 nM）。= 29.5 nm)。 了解更多 -
Ipatasertib dihydrochloride
Catalog No. A21734 pan-Akt inhibitorIpatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. 了解更多 -
Cobimetinib hemifumarate
Catalog No. A18033 MEK1 inhibitorCobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. 了解更多 -
Belvarafenib
Catalog No. A13177 pan RAF inhibitorBelvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. 了解更多 -
Cobimetinib (racemate)
Catalog No. A15050 -
Cobimetinib (R-enantiomer)
Catalog No. A15051 MEK 抑制剂Cobimetinib R-enantiomer是Cobimetinib的R对映异构体，Cobimetinib是一种有力的，高选择性的促分裂原活化蛋白激酶（MEK1/2）抑制剂。 了解更多 -
ABT-199 (Venetoclax)
Catalog No. A12500 Bcl-2 抑制剂ABT-199 (Venetoclax) 是一种所谓的BH3类似药物，旨在阻断Bcl 2蛋白的功能。 了解更多 -
PF-06700841 P-Tosylate
Catalog No. A21652 dual JAK1/TYK2 inhibitorPF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. 了解更多 -
PF-06700841 tosylate
Catalog No. A17176 -
G-479
Catalog No. A14380 -
Arbutin (Uva, p-Arbutin)
Catalog No. A10084 Tyrosinase 抑制剂Arbutin (Uva,p-Arbutin)是用于中药（TCM）的糖基化对苯二酚。 熊果苷由于其酪氨酸酶抑制活性而抑制黑色素的形成。 了解更多
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