Proteases

产品 201 到 250 共 319个

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  1. Velpatasvir

    Catalog No. A17302
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    HCV NS5A inhibitor
    Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. 了解更多
  2. Ombitasvir (ABT-267)

    Catalog No. A17624
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    HCV NS5A inhibitor
    Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. 了解更多
  3. Paritaprevir (ABT-450)

    Catalog No. A17625
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    HCV NS3/4A inhibitor
    Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. 了解更多
  4. Ledipasvir acetone

    Catalog No. A18055
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    HCV NS5A inhibitor
    Ledipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. 了解更多
  5. Voxilaprevir

    Catalog No. A12067
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    HCV NS 3/4A protease inhibitor
    Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs). 了解更多
  6. PSI-7409

    Catalog No. A13962
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    nucleotide analog HCV inhibitor
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. 了解更多
  7. Mericitabine

    Catalog No. A11539
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    HCV NS5B polymerase inhibitor
    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. 了解更多
  8. R-1479

    Catalog No. A11540
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    HCV replication inhibitor
    R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). 了解更多
  9. PSI-352938

    Catalog No. A21253
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    HCV nucleotide inhibitor
    PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor. 了解更多
  10. Beclabuvir

    Catalog No. A21511
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    HCV NS5B RNA-dependent RNA polymerase inhibitor
    Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. 了解更多
  11. PSI-7976

    Catalog No. A21631
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    HCV RNA replication inhibitor
    PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. 了解更多
  12. Sofosbuvir impurity C

    Catalog No. A21636
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    HCV RNA replication inhibitor
    Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. 了解更多
  13. Sofosbuvir impurity A

    Catalog No. A21641
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    HCV RNA replication inhibitor
    Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity. 了解更多
  14. NM107

    Catalog No. A21761
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    HCV NS5B polymerase
    NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM. 了解更多
  15. PSI-6206 13CD3

    Catalog No. A21782
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    HCV NS5B polymerase inhibitor
    PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. 了解更多
  16. HCV-IN-3

    Catalog No. A20957
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    HCV NS3/4a protein inhibitor
    HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. 了解更多
  17. MLN9708

    Catalog No. A10602
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    Proteasome 抑制剂
    MLN9708是一种蛋白酶体抑制剂,可抑制蛋白酶体的活性,从而阻断通常由蛋白酶体进行的靶向蛋白水解。 了解更多
  18. Bortezomib (Velcade)

    Catalog No. A10160
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    Proteasome 抑制剂
    Bortezomib (Velcade)是26S蛋白酶体的高度选择性,可逆抑制剂。 了解更多
  19. MG-132

    Catalog No. A11043
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    Proteasome 抑制剂
    MG-132是蛋白酶体(IC50 = 100 nM)和钙蛋白酶(IC50 = 1.2μM)的有效的细胞渗透抑制剂。 了解更多
  20. MLN2238 (Ixazomib)

    Catalog No. A10600
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    Proteasome 抑制剂
    MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点,IC50值为3.4 nM。 了解更多
  21. CEP-18770 (Delanzomib)

    Catalog No. A11145
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    Proteasome 抑制剂
    CEP-18770 (Delanzomib)是一种新型口服活性蛋白酶体抑制剂,IC50为3.8 nM,具有良好的肿瘤选择性,可用于治疗对蛋白酶体抑制有反应的MM和其他恶性肿瘤。 了解更多
  22. PR-171 (Carfilzomib)

    Catalog No. A11278
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    Proteasome 抑制剂
    PR-171 (Carfilzomib)是四肽环氧酮和选择性蛋白酶体抑制剂。它是环氧霉素的类似物。 了解更多
  23. ONX-0914

    Catalog No. A12653
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    Immunoproteasome 抑制剂
    ONX 0914是有效,选择性的免疫蛋白酶体亚基LMP7的抑制剂,在自身免疫性疾病(如类风湿性关节炎,炎性肠病和狼疮)中具有潜在的治疗应用。ONX 0914被设计为一种有效的免疫蛋白酶抑制剂,对组成型蛋白酶体的交叉反应最小。 了解更多
  24. Lactacystin

    Catalog No. A12768
    proteasome 抑制剂
    Lactacystin是一种细胞可渗透的,有效的和选择性的蛋白酶体抑制剂。 了解更多
  25. Gliotoxin

    Catalog No. A13711
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    20S proteasome 抑制剂
    Gliotoxin是由曲霉菌和其他真菌的致病菌株产生的一种免疫抑制性真菌毒素。 了解更多
  26. PSI

    Catalog No. A14048
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    Proteasome 抑制剂
    PSI是蛋白酶体抑制剂,其抑制蛋白酶体的胰凝乳蛋白酶样活性。 了解更多
  27. ONX 0912 (Oprozomib)

    Catalog No. A14181
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    Proteasome 抑制剂
    ONX 0912 (Oprozomib)是一种三肽环氧酮,可抑制对常规和硼替佐米治疗耐药的MM细胞的生长并诱导其凋亡。 了解更多
  28. PI-1840

    Catalog No. A14146
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    reversible proteasome 抑制剂
    PI-1840是一种具有抗肿瘤活性的新型非共价快速可逆蛋白酶体抑制剂。 了解更多
  29. Marizomib (NPI-0052, salinosporamide A)

    Catalog No. A13853
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    Proteasome 抑制剂
    Marizomib (NPI-0052,salinosporamide A)是一种天然存在的salinosporamide,从海洋放线菌Salinospora tropica中分离出来,具有潜在的抗肿瘤活性。 了解更多
  30. Aclacinomycin A

    Catalog No. A14910
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    20S proteasome 抑制剂
    Aclacinomycin A是一种蒽环类药物,是20S蛋白酶体胰凝乳蛋白酶样活性的特异性抑制剂。 了解更多
  31. Dihydroeponemycin

    Catalog No. A14932
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    Proteasome 抑制剂
    Dihydroeponemycin是蛋白酶体和抗肿瘤剂的抑制剂。 了解更多
  32. Clasto-Lactacystin b-lactone

    Catalog No. A15427
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    20S proteasome 抑制剂
    Clasto-Lactacystin b-lactone被鉴定为乳酸的活性代谢产物,这是由于半胱氨酸的消除和反应性b-内酯的形成所致。 了解更多
  33. MG-115

    Catalog No. A11601
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    Reversible Proteasome 抑制剂
    MG-115是一种有效的,可逆的肽醛抑制剂,具有蛋白酶类胰凝乳蛋白酶样和胱天蛋白酶样活性。 它诱导p53依赖性细胞凋亡。 了解更多
  34. MG-262

    Catalog No. A12220
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    Proteasome 抑制剂
    MG-262一种硼酸肽,是一种有效的蛋白酶体抑制剂,它选择性地和可逆地抑制蛋白酶体的糜蛋白酶活性。 了解更多
  35. AM 114

    Catalog No. A14922
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    20S proteasome 抑制剂
    AM 114是硼查尔酮的衍生物,是一种有效的蛋白酶体小分子抑制剂,可抑制20S蛋白酶体的胰凝乳蛋白酶样活性,其50%抑制浓度的IC50值约为1 uM,导致大量积累 泛素化的p53和其他细胞蛋白在整个细胞中的表达,而不会显着破坏p53与鼠类double minutes 2(mdm2)蛋白的相互作用。 了解更多
  36. Epoxomicin

    Catalog No. A12730
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    Proteasome 抑制剂
    Epoxomicin是从放线菌中分离出来的一种有效的抗肿瘤药,被用作20S蛋白酶体的选择性和不可逆抑制剂。 了解更多
  37. VR23

    Catalog No. A13650
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    Proteasome 抑制剂?
    VR23是一个小分子,可有效抑制胰蛋白酶样蛋白酶体(IC50 = 1 nM),胰凝乳蛋白酶样蛋白酶体(IC50 = 50-100 nM)和半胱天冬酶样蛋白酶体(IC50 = 3uM)的活性。 了解更多
  38. ML604440

    Catalog No. A18826
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    proteasome β1i (LMP2) subunit inhibitor
    ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor. 了解更多
  39. Proteasome-IN-1

    Catalog No. A12254
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    proteasome inhibitor
    Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1. 了解更多
  40. Ixazomib citrate

    Catalog No. A18017
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    20S proteasome inhibitor
    Ixazomib citrate (MLN9708) is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM. 了解更多
  41. (R)-MG-132

    Catalog No. A21980
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    proteasome inhibitor
    (R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132. 了解更多
  42. RO4929097

    Catalog No. A10802
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    Gamma-secretase 抑制剂
    RO4929097是一种γ secretase抑制剂,无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工,EC50分别为14 nM和5 nM。 了解更多
  43. BMS-708163 (Avagacestat)

    Catalog No. A10157
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    Gamma-secretase 抑制剂
    BMS-708163 (Avagacestat)是口服生物有效的,选择性的γ-分泌酶抑制剂,作用于Aβ40和Aβ42时,IC50分别为0.3 nM和0.27 nM。 了解更多
  44. MK-0752

    Catalog No. A11194
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    Gamma-secretase 抑制剂
    MK-0752抑制Notch信号通路,这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。 了解更多
  45. DAPT (GSI-IX)

    Catalog No. A10288
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    Gamma secretase 抑制剂
    DAPT (GSI-IX)是一种γ-分泌酶抑制剂,可导致人原代神经元培养物中Aβ40和Aβ42水平降低,总Aβ和Aβ42的IC50值分别为115和200 nM。 了解更多
  46. YO-01027

    Catalog No. A11174
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    γ-secretase 抑制剂
    YO-01027是一种二肽γ-secretase抑制剂,作用于APPL和Notch分裂, 无细胞试验中IC50分别为2.6 nM和2.9 nM,一种抗阿尔茨海默氏病药物。 了解更多
  47. LY-411575

    Catalog No. A11176
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    Gamma secretase 抑制剂
    LY-411575是一种选择性的,细胞可渗透的小分子γ-secretase抑制剂。在表达APP或NΔE的HEK293细胞中IC50为0.078 nM/0.082 nM(基于膜/细胞),也抑制Notch分裂,IC50为0.39 nM。 了解更多
  48. Semagacestat (LY450139)

    Catalog No. A10836
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    Gamma-secretase 抑制剂
    Semagacestat (LY450139)是一种针对Aβ42,Aβ40和Aβ38的γ-分泌酶阻滞剂,IC50分别为10.9 nM,12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导,IC50为14.1 nM。 了解更多
  49. LY2811376

    Catalog No. A11776
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    BACE1 抑制剂
    LY2811376是第一种可口服的非肽类BACE1抑制剂,可在动物体内产生显着的Aβ降低作用。 了解更多
  50. BMS 433796

    Catalog No. A11337
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    γ-Secretase 抑制剂
    BMS 433796是在阿尔茨海默病转基因小鼠模型中具有Aβ降低活性的γ分泌酶抑制剂。 了解更多

产品 201 到 250 共 319个

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  5. 7

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