PDGFR

Catalog No.Inhibitor Name PDGFRPDGFRαPDGFRβOther
A10001Sorafenib Tosylate
**
**
Raf-1,VEGFR2/Flk1,B-Raf
A10468Imatinib Mesylate
c-Kit,v-Abl
A10880Sunitinib Malate
****
FLT3,Kit,VEGFR2
A10080Ponatinib
****
Abl,VEGFR2,FGFR1
A10103Axitinib
***
****
VEGFR1/FLT1,VEGFR2/Flk1,VEGFR3
A10259Imatinib
**
c-Kit,v-Abl
A10137Nintedanib
**
**
VEGFR3,VEGFR2,LCK
A10699Pazopanib HCl
**
VEGFR1,VEGFR2,VEGFR3
A11411Dovitinib
*
***
FLT3,c-Kit,FGFR1
A10025Linifanib
**
VEGFR1/FLT1,CSF-1R,FLT3
A11052Crenolanib
****
****
A10558Masitinib
*
*
Kit,Lyn B,Abl1
A10101Tivozanib
***
**
VEGFR2,VEGFR3,EphB2
A10610Amuvatinib
***
c-Kit (D816H),FLT3 (D835Y)
A10608Motesanib Diphosphate
**
VEGFR1,VEGFR2,VEGFR3
A10953Orantinib
***
FGFR1,Flk1
A11350CP-673451
***
****
c-Kit,VEGFR2,VEGFR1
A10502Ki8751
**
VEGFR2,c-Kit,FGFR2
A10903Telatinib
***
c-Kit,VEGFR3,VEGFR2
A11207PP121
****
Hck,VEGFR,mTOR
A11518Pazopanib
**
VEGFR1,VEGFR2,VEGFR3
A10504KRN 633
*
*
VEGFR3,VEGFR2,VEGFR1
A10198Dovitinib Dilactic Acid
*
***
FLT3,c-Kit,VEGFR3/FLT4
A11753MK-2461
***
c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
A14156AZD2932
****
Flt3,VEGFR-2,c-Kit
A15062DCC-2618
***
***
c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. R1530

    Catalog No. A13111
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    Chk2, KDR, FGFR, Aurora A & Cdk2 抑制剂
    R1530是吡唑并苯并二氮杂小分子,具有潜在的抗血管生成和抗肿瘤活性。R1530也是一种有丝分裂-血管生成抑制剂(MAI),可抑制多种参与血管生成的受体酪氨酸激酶,如血管内皮生长因子受体(VEGFR)-1,-2,-3,血小板衍生生长因子受体(PDGFR)βFMS样酪氨酸激酶(Flt)-3和成纤维细胞生长因子受体(FGFR) -1,-2。 了解更多
  2. Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  3. TSU-68 (Orantinib, SU6668)

    Catalog No. A10953
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    PDFGRβ 抑制剂
    TSU-68 (Orantinib,SU6668)在无细胞试验中具有8 nM的Ki对PDGFR自磷酸化的最大效力,但也强烈抑制Flk-1和FGFR1反磷酸化,对IGF-1R,Met,Src, Lck,Zap70,Abl和CDK2; 不抑制EGFR。 了解更多
  4. Nintedanib esylate

    Catalog No. A16197
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    RTK 抑制剂
    Nintedanib esylate是多种受体酪氨酸激酶(RTK)和非受体酪氨酸激酶(nRTK)的有效抑制剂。 了解更多
  5. AP24534 (Ponatinib)

    Catalog No. A10080
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    BCR-ABL 抑制剂
    AP24534 (Ponatinib)是有效的多激酶和pan-BCR-ABL抑制剂。 了解更多

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