CDK

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作用机制
  1. Inhibitor (抑制剂) (96)
  2. Agonist (激动剂) (1)
  3. Degrader (降解剂) (1)
靶点
  1. Aurora A (1)
  2. Aurora B (1)
  3. CDK (3)
  4. CDK4 (2)
  5. FLT3 (3)
  6. JAK2 (2)
Catalog No.Inhibitor Name CDK1CDK2CDK3CDK4CDK5CDK6CDK7CDK8CDK9CLKCDKCdcOther
A10701Palbociclib HCl
****
***
A10806Roscovitine
*
**
*
ERK2,GST-ERK1,ERK1
A10850SNS-032
*
***
*
*
**
****
GSK-3α,GSK-3β
A11129Dinaciclib
****
****
****
****
A10390Flavopiridol
***
***
***
**
*
A10093AT7519
**
**
**
***
**
*
****
GSK-3β
A11045Flavopiridol HCl
***
***
*
***
***
*
A10494JNJ-7706621
****
****
*
**
Aurora A,Aurora B,VEGFR2
A11105AZD5438
***
****
**
***
A11167MK-8776
**
Chk1,Chk2
A10716PHA-793887
**
****
**
****
****
**
GSK-3β
A10163BS-181 HCl
***
A13811Palbociclib Isethionate
****
***
A11034A-674563
**
Akt1,PKA,GSK-3β
A16386abemaciclib
****
****
A11154BMS-265246
****
****
**
A11164PHA-767491
**
**
*
***
****
****
GSK-3β,MK2,PLK1
A11047Milciclib
*
***
**
*
**
TrkA
A11190R547
****
****
****
GSK-3β
A14136NU6027
*
*
ATR,DNA-PK
A13547P276-00
**
**
**
*
*
***
GSK-3β,PKCα,c-Src
A11220Kenpaullone
*
*
*
GSK-3β,ERK2,c-Src
A15889K03861
****
A14192THZ1
****
A11313AT7519 HCl
**
**
*
**
***
**
*
****
GSK-3β
A15517Purvalanol A
***
*
****
A14437Ro-3306
***
PKCδ,SGK,ERK
A14318SU9516
***
***
**
PDGFR
A13677XL413
****
****
Pim1,CK2
A14273LDC000067
*
*
*
***
A14297ML167
**
A13721TG003
***
A13549Ribociclib
A12216Wogonin
A10471Indirubin
*
GSK-3β
A11347CGP60474
***
***
PKCα
A12352Purvalanol B
****
****
A12438NU 6102
***
****
*
A12989LY2835219 (abemaciclib)
****
***
A14025AMG-925
*
****
FLT3
A15054CVT 313
*
*
*
A15196NVP-LCQ195
****
***
****
CHK2
A15767NU2058
*
*
DNA topoisomerase II ATPase
A15823LY2857785
*
***
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 97个

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  1. P276-00

    Catalog No. A13547
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    CDK 抑制剂
    P276-00是一种新型CDK1,CDK4和CDK9抑制剂,IC50分别为79 nM,63 nM和20 nM。在第2/3阶段。 了解更多
  2. LEE011 (Ribociclib)

    Catalog No. A13549
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    CDK4/6 抑制剂
    LEE011 (Ribociclib)是一种可口服的细胞周期蛋白依赖性激酶(CDK)抑制剂,靶向细胞周期蛋白D1/CDK4和细胞周期蛋白D3/CDK6细胞周期途径,具有潜在的抗肿瘤活性。 了解更多
  3. LDC000067

    Catalog No. A14273
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    CDK 抑制剂
    LDC000067是一种高选择性CDK9抑制剂。 了解更多
  4. PD 0332991 Isethionate

    Catalog No. A13811
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  5. AMG-925

    Catalog No. A14025
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    Dual FLT3/CDK4 抑制剂
    AMG-925是一种有效,选择性和生物利用性的FLT3/细胞周期蛋白依赖性激酶4(CDK4)双激酶抑制剂。 了解更多
  6. CVT-313

    Catalog No. A15054
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    CDK2 抑制剂
    CVT-313是一种有效,选择性,可逆且具有ATP竞争性的CDK2抑制剂(对于Cdk2/A和Cdk2/E,IC50 = 0.5 uM;对于Cdk1/B为4.2 uM;对于Cdk4/D1为215 uM)。 了解更多
  7. Purvalanol A

    Catalog No. A15517
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    CDK 抑制剂
    Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶(cdk)抑制剂。对于cdc2/cyclin B,cdk2/cyclin A,cdk2/cyclin E,cdk4/cyclin D1和cdk5-p35,IC50值分别为4、70、35、850和75 nM。 了解更多
  8. NVP-LCQ195

    Catalog No. A15196
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    CDK 抑制剂
    NVP-LCQ195是CDK1,CDK2,CDK3和CDK5的小分子杂环抑制剂,IC50为1-42 nM。 了解更多
  9. AG-024322

    Catalog No. A15485
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    CDK 抑制剂
    AG-24322是第二代CDK抑制剂。AG-024322是有效的CDK1,CDK2和CDK4抑制剂,可在临床前模型中产生细胞周期停滞和抗肿瘤活性。 了解更多
  10. NU2058

    Catalog No. A15767
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    CDK 抑制剂
    NU2058是基于鸟嘌呤的CDK抑制剂,对CDK2和CDK1的IC50为17 uM和26 uM。 了解更多
  11. Palbociclib

    Catalog No. A14427
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    CDK 抑制剂
    Palbociclib是一种吡啶并嘧啶衍生的细胞周期蛋白依赖性激酶(CDK)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  12. CDK8-IN-1

    Catalog No. A12961
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    CDK8 inhibitor
    CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. 了解更多
  13. CDK-IN-2

    Catalog No. A11353
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    CDK9 inhibitor
    CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. 了解更多
  14. Senexin A

    Catalog No. A21166
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    CDK8 inhibitor
    Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. 了解更多
  15. Voruciclib hydrochloride

    Catalog No. A21385
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    CDK inhibitor
    Voruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. 了解更多
  16. PHA-767491 hydrochloride

    Catalog No. A21395
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    dual Cdc7/Cdk9 inhibitor
    PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. 了解更多
  17. CDKI-73

    Catalog No. A21467
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    CDK9 inhibitor
    CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). 了解更多
  18. CDK9-IN-1

    Catalog No. A21552
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    CDK9 inhibitor
    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87. 了解更多
  19. (±)-BAY-1251152

    Catalog No. A21564
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    PTEF/CDK9 inhibitor
    (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. 了解更多
  20. (-)-BAY-1251152

    Catalog No. A21570
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    PTEF/CDK9 inhibitor
    (-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. 了解更多
  21. Lerociclib dihydrochloride

    Catalog No. A21577
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    CDK4/CDK6 inhibitor
    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多
  22. LDC4297

    Catalog No. A21613
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    CDK7 inhibitor
    LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. 了解更多
  23. BS-181 hydrochloride

    Catalog No. A21988
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    CDK7 inhibitor
    BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. 了解更多
  24. SEL120-34A HCl

    Catalog No. A21485
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    CDK8 inhibitor
    SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. 了解更多
  25. NU6300

    Catalog No. A21025
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    ATP-competitive CDK2 inhibitor
    NU6300 is the first covalent ATP-competitive CDK2 inhibitor. 了解更多
  26. PD 0332991 HCl (Palbociclib)

    Catalog No. A10701
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    CDK 4/6 抑制剂
    PD 0332991 HCl (Palbociclib)是一种高度选择性的CDK4/6抑制剂,它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性,具有潜在的抗肿瘤活性。 了解更多
  27. Flavopiridol (Alvocidib)

    Catalog No. A10390
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    CDK 抑制剂
    Flavopiridol(Alvocidib)是一种细胞周期蛋白依赖性激酶抑制剂,与ATP竞争性抑制CDK,包括CDK1, CDK2, CDK4和CDK6,CDK9。作用于CDK1, 2, 4, 6,9比作用于CDK7更具有选择性,用于治疗慢性淋巴细胞性白血病。 了解更多
  28. A-674563

    Catalog No. A11034
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    Akt 抑制剂
    A-674563是一种B/Akt抑制剂,IC50为14 nM,并且还显示出对PKA和CDK2的抑制活性,IC50分别为16和46 nM。 了解更多
  29. Roscovitine (Seliciclib)

    Catalog No. A10806
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    CDK 抑制剂
    Roscovitine (Seliciclib)是一种CDK抑制剂,可优先抑制多种酶靶标,包括CDK2,CDK7和CDK9。 了解更多
  30. PHA-793887

    Catalog No. A10716
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    CDK 抑制剂
    PHA-793887是一种新型有效的CDK2,CDK5和CDK7抑制剂,IC50分别为8 nM,5 nM 和10 nM,作用于CDK2,5,和7比作用于CDK1,4,和9选择性高6倍以上。可在低浓度下靶向多种细胞周期蛋白依赖性激酶,并具有针对多种癌细胞的高活性。 了解更多
  31. PHA-767491

    Catalog No. A11164
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    Cdc7/cdk9 抑制剂
    PHA-767491是一种有效的,具有ATP竞争性的双重cdc7/cdk9抑制剂 (IC50值分别为10和34 nM),可防止DNA复制的启动。 了解更多
  32. SCH 900776 (MK-8776)

    Catalog No. A11167
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    Chk1 抑制剂
    SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1(Chk1)的药物,无细胞试验中IC50为3 nM,比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。 了解更多
  33. Dinaciclib (SCH 727965)

    Catalog No. A11129
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    CDK 抑制剂
    Dinaciclib (SCH 727965)是一种有效且选择性的细胞周期蛋白依赖性激酶(CDK)抑制剂,选择性抑制CDK1,CDK2,CDK5和CDK9,IC50值分别为3、1、1和4 nM。 了解更多
  34. Kenpaullone

    Catalog No. A11220
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    CDK 抑制剂
    Kenpaullone是CDK1/细胞周期蛋白B(IC 50 = 400 nM),CDK2/细胞周期蛋白A(IC 50 = 680nM),CDK5(IC 50 = 850nM)的有效抑制剂,对其他激酶的作用要小得多。 了解更多
  35. BMS-863233 (XL-413)

    Catalog No. A13677
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    CDK 抑制剂
    BMS-863233,也称为XL-413,是一种具有潜在抗肿瘤活性的细胞分裂周期7同系物(CDC7)激酶抑制剂。 了解更多
  36. LY2835219 (abemaciclib)

    Catalog No. A12989
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    CDK4/6 抑制剂
    LY2835219 (abemaciclib)是一种细胞周期蛋白依赖性激酶(CDK)抑制剂,靶向CDK4(cyclin D1)和CDK6(cyclin D3)细胞周期途径,具有潜在的抗肿瘤活性。 了解更多
  37. BAY 1000394 (Roniciclib)

    Catalog No. A12742
    CDK 抑制剂
    BAY 1000394 (Roniciclib)是一种口服生物利用细胞周期蛋白依赖性激酶(CDK)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  38. Abemaciclib Metabolites M2

    Catalog No. A18416
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    CDK4/CDK6 inhibitor
    Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多
  39. CDK2-IN-4

    Catalog No. A18667
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    CDK2 inhibitor
    CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM). 了解更多
  40. FMF-04-159-2

    Catalog No. A18911
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    CDK14 inhibitor
    FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. 了解更多
  41. THAL-SNS-032

    Catalog No. A19088
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    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
  42. SY-1365

    Catalog No. A18482
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    CDK7 inhibitor
    SY-1365 is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. 了解更多
  43. bio-THZ1

    Catalog No. A18559
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    covalent CDK7 inhibitor
    bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. 了解更多
  44. CDK4/6-IN-2

    Catalog No. A18657
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    CDK4/CDK6 inhibitor
    CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively. 了解更多
  45. BI-1347

    Catalog No. A18769
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    CDK8 inhibitor
    BI-1347 is a selective inhibitor of CDK8/cyclin C with an IC50 of 1.1 nM. 了解更多
  46. MC180295

    Catalog No. A18892
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    CDK9 inhibitor
    MC180295 is a highly selective CDK9 inhibitor (IC50 = 5 nM). MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect. 了解更多
  47. Lerociclib (G1T38)

    Catalog No. A18320
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    CDK inhibitor
    Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多
  48. AZD4573

    Catalog No. A18321
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    CDK9 inhibitor
    AZD4573 is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. 了解更多
  49. NVP-2

    Catalog No. A17022
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    CDK9 抑制剂
    NVP-2是一种有效的选择性ATP竞争性CDK9抑制剂,IC50值为0.5 nM。 了解更多
  50. BAY-1251152

    Catalog No. A17029
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    CDK9 抑制剂
    BAY-1251152,也称为(+)-BAY-1251152,是CDK9抑制剂。 了解更多

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