Aurora Kinase

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Aurora A	Aurora B	Aurora C	Other
A10004	Alisertib	****	*
A10981	Tozasertib	****	**	***	Bcr-Abl,FLT3
A10109	Barasertib	*	****
A11009	ZM 447439	**	*		LCK,Src,MEK1
A10601	MLN8054	****	*		LCK,PKA,CK2
A10715	Danusertib	***	**	**	Abl,TrkA,RET
A10095	AT9283	****	****		JAK3,JAK2,Abl1 (T315I)
A10494	JNJ-7706621	***	***		CDK2/CyclinE,CDK2/CyclinA,CDK1/CyclinB
A10448	Hesperadin		*		TbAUK1
A10100	Aurora A Inhibitor I	****	*	*
A10508	KW-2449	**			FLT3 (D835Y),Abl (T315I),FLT3
A10851	SNS-314 Mesylate	***	**	****
A10352	ENMD-2076	***	*		FLT3,RET,VEGFR3/FLT4
A10714	PHA-680632	**	*	*	FGFR1,PLK1,FLT3
A11410	MK-5108	****
A10248	CYC116	***	***		VEGFR2,FLT3,CDK2/CyclinE
A11066	AMG-900	***	****	****	p38α,TYK2,JNK2
A11171	PF-03814735	****	***		FLT1,FAK,TrkA
A10184	CCT129202	**	*	*
A11168	GSK1070916	*	****	***	FLT1,Tie-2,SIK
A11067	TAK-901	**	***		JAK3,c-Src,YES1
A11081	CCT137690	***	**	**
A13396	MK-8745	****	*
A10352	ENMD-2076 L-(*)-Tartaric acid	***	*		FLT3,RET,VEGFR3/FLT4
A15762	BI-847325	**	****	***
A13250	Reversine	***	***	**	human A3 adenosine receptor

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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KW-2449

Catalog No. A10508
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FLT3/FGFR/Bcr-Abl/Aurora 抑制剂

KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。了解更多

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PF-03814735

Catalog No. A11171
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Aurora A/B Kinase 抑制剂

PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。了解更多

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ENMD-2076

Catalog No. A10352
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Aurora A / FLT3 抑制剂

ENMD-2076具有针对Aurora A和Flt3的选择性活性，IC50为14 nM和1.86 nM，对Aurora A的选择性是Aurora B的25倍，对VEGFR2/KDR和VEGFR3，FGFR1和FGFR2和PDGFRα的作用较小。阶段2。了解更多

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