Aurora Kinase

Catalog No.Inhibitor Name Aurora AAurora BAurora COther
A10004Alisertib
****
*
A10981Tozasertib
****
**
***
Bcr-Abl,FLT3
A10109Barasertib
*
****
A11009ZM 447439
**
*
LCK,Src,MEK1
A10601MLN8054
****
*
LCK,PKA,CK2
A10715Danusertib
***
**
**
Abl,TrkA,RET
A10095AT9283
****
****
JAK3,JAK2,Abl1 (T315I)
A10494JNJ-7706621
***
***
CDK2/CyclinE,CDK2/CyclinA,CDK1/CyclinB
A10448Hesperadin
*
TbAUK1
A10100Aurora A Inhibitor I
****
*
*
A10508KW-2449
**
FLT3 (D835Y),Abl (T315I),FLT3
A10851SNS-314 Mesylate
***
**
****
A10352ENMD-2076
***
*
FLT3,RET,VEGFR3/FLT4
A10714PHA-680632
**
*
*
FGFR1,PLK1,FLT3
A11410MK-5108
****
A10248CYC116
***
***
VEGFR2,FLT3,CDK2/CyclinE
A11066AMG-900
***
****
****
p38α,TYK2,JNK2
A11171PF-03814735
****
***
FLT1,FAK,TrkA
A10184CCT129202
**
*
*
A11168GSK1070916
*
****
***
FLT1,Tie-2,SIK
A11067TAK-901
**
***
JAK3,c-Src,YES1
A11081CCT137690
***
**
**
A13396MK-8745
****
*
A10352ENMD-2076 L-(*)-Tartaric acid
***
*
FLT3,RET,VEGFR3/FLT4
A15762BI-847325
**
****
***
A13250Reversine
***
***
**
human A3 adenosine receptor

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PF-03814735

    Catalog No. A11171
    Aurora A/B Kinase 抑制剂
    PF-03814735是一种新颖,有效且可逆的Aurora A/B抑制剂,IC50为0.8 nM/5 nM,对Flt3,FAK,TrkA的效力较低,对Met和FGFR1的活性最低。 了解更多
  2. ENMD-2076

    Catalog No. A10352
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    Aurora A / FLT3 抑制剂
    ENMD-2076具有针对Aurora A和Flt3的选择性活性,IC50为14 nM和1.86 nM,对Aurora A的选择性是Aurora B的25倍,对VEGFR2/KDR和VEGFR3,FGFR1和FGFR2和PDGFRα的作用较小。阶段2。 了解更多
  3. KW-2449

    Catalog No. A10508
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    FLT3/FGFR/Bcr-Abl/Aurora 抑制剂
    KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。 了解更多

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