Aurora Kinase

Catalog No.Inhibitor Name Aurora AAurora BAurora COther
A10004Alisertib
****
*
A10981Tozasertib
****
**
***
Bcr-Abl,FLT3
A10109Barasertib
*
****
A11009ZM 447439
**
*
LCK,Src,MEK1
A10601MLN8054
****
*
LCK,PKA,CK2
A10715Danusertib
***
**
**
Abl,TrkA,RET
A10095AT9283
****
****
JAK3,JAK2,Abl1 (T315I)
A10494JNJ-7706621
***
***
CDK2/CyclinE,CDK2/CyclinA,CDK1/CyclinB
A10448Hesperadin
*
TbAUK1
A10100Aurora A Inhibitor I
****
*
*
A10508KW-2449
**
FLT3 (D835Y),Abl (T315I),FLT3
A10851SNS-314 Mesylate
***
**
****
A10352ENMD-2076
***
*
FLT3,RET,VEGFR3/FLT4
A10714PHA-680632
**
*
*
FGFR1,PLK1,FLT3
A11410MK-5108
****
A10248CYC116
***
***
VEGFR2,FLT3,CDK2/CyclinE
A11066AMG-900
***
****
****
p38α,TYK2,JNK2
A11171PF-03814735
****
***
FLT1,FAK,TrkA
A10184CCT129202
**
*
*
A11168GSK1070916
*
****
***
FLT1,Tie-2,SIK
A11067TAK-901
**
***
JAK3,c-Src,YES1
A11081CCT137690
***
**
**
A13396MK-8745
****
*
A10352ENMD-2076 L-(*)-Tartaric acid
***
*
FLT3,RET,VEGFR3/FLT4
A15762BI-847325
**
****
***
A13250Reversine
***
***
**
human A3 adenosine receptor

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SAR156497

    Catalog No. A14382
    Aurora Kinase 抑制剂
    SAR156497是一种选择性选择性的Aurora A,B和C抑制剂,具有体外和体内功效,IC50分别为0.5 nM(Aurora A),1 nM(Aurora B/incenp),3 nM(Aurora C/incenp)SAR156497组合具有很高的体外药效,具有令人满意的代谢稳定性,并且对CYP3A4和PDE3的抑制作用有限。 了解更多

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