Raf

Catalog No.Inhibitor Name RafC-Raf/Raf-1B-RafA-rafOther
A10739Vemurafenib
*
**
SRMS,ACK1,MAP4K5 (KHS1)
A10002PLX-4720
***
***
BRK,FRK,CSK
A11381Dabrafenib
****
****
A10420GDC-0879
****
A10773RAF265
**
VEGFR2
A11063AZ 628
**
**
A10661NVP-BHG712
*
EphB4,c-Src,c-Abl
A10829SB590885
****
A11077ZM 336372
*
A10001Sorafenib
****
**
mVEGFR2(Flk1),mVEGFR3,mPDGFRβ
A11436GW5074
***
A13323TAK-632
****
***
Aurora B,PDGFRβ,FGFR3
A13772CEP-32496
**
***
RET,PDGFRβ,LCK
A13226Encorafenib
****
A14019RO5126766
*
***
MEK1
A15855PLX7904
A11240MLN2480
A10250Regorafenib (BAY 73-4506)
****
**
FGFR1, Kit, PDGFRβ, RET, Tie-2 , VEGFR1, VEGFR2, VEGFR3
A11211ML 786 dihydrochloride
****
****
Abl-1, DDR2, EPHA2, RET, PERK
A12739PF-04880594
****
****
A13525L-779450
****
p38α, GSK3β, Lck

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Sorafenib Tosylate (Nexavar)

    Catalog No. A10001
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    Raf 抑制剂
    Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂,Raf-1,wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。 了解更多
  2. CEP-32496 hydrochloride

    Catalog No. A15040
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    Raf 抑制剂
    CEP-32496 hydrochloride是野生型BRAF,V600E突变型BRAF和c-Raf的高效抑制剂,Kd值分别为14 nM,36 nM和39 nM。 了解更多
  3. TAK-632

    Catalog No. A13323
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    pan-RAF 抑制剂
    TAK-632是一种有效的泛RAF抑制剂,具有良好的体外活性(BRAF(V600E)IC50,2.4 nM; BRAF(wt),8.3 nM; CRAF,1.4 nM; pMEK(A375)IC50,12 nM; pMEK(HMVII ),49 nM。 了解更多
  4. Regorafenib monohydrate

    Catalog No. A15218
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    Tyrosine kinase 抑制剂
    Regorafenib monohydrate是VEGFR1/VEGFR2/VEGFR3/PDGFRβ/Kit/RET和Raf-1的多靶点抑制剂,IC50分别为13 nM/4.2 nM/46 nM/22 nM/7 nM/1.5 nM和2.5 nM。 了解更多
  5. CEP-32496

    Catalog No. A13772
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    Raf 抑制剂
    CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1(B-raf)丝氨酸/苏氨酸蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多

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