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搜索结果：“MK 1775”

“MK 1775”的搜索结果

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MK-0359

Catalog No. A13467
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PDE4 抑制剂

MK-0359是一种选择性和有效的口服PDE4抑制剂，用于慢性哮喘。了解更多

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A-484954

Catalog No. A13447
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eEF2K (CAMKIII) 抑制剂

A-484954是一种有效的、选择性的真核细胞延长因子-2激酶（eEF2K）抑制剂。了解更多

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AAF-CMK

Catalog No. A13605
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Serine protease 抑制剂

AAF-CMK是一种丝氨酸蛋白酶抑制剂，它不可逆地抑制TPPII（三肽基肽酶II），TPPII是一种巨大的蛋白酶，可以替代某些蛋白酶体功能，并且可逆地抑制Cln2（TPPI）。了解更多

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Glycyl-H 1152 2HCl

Catalog No. A13659
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ROCK 抑制剂

Glycyl-H 1152 2HCl是一种选择性有效的ROCK抑制剂（ROCKII，Aurora A，CAMKII，PKG，PKA和PKC的IC50值分别为0.0118、2.35、2.57、3.26，> 10和> 10 uM。）了解更多

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MK-5172

Catalog No. A13787
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HCV NS3/4a 抑制剂

MK-5172是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂，在基因型和耐药变异中具有广泛的活性。了解更多

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Sitagliptin

Catalog No. A14377
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DDP-4 抑制剂

Sitagliptin是二肽基肽酶-4（DPP-4）抑制剂类别降糖药（抗糖尿病药）。了解更多

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- Hae Jin Kim, .et al. Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug, Korean J Physiol Pharmacol, 2018, Nov; 22(6): 713-719 PMID: 30402032
- Chintan N. Koyani, .et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes, Front Physiol, 2018, 9: 1622 PMID: 30487758
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Z-LEHD-FMK

Catalog No. A14358
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Caspase-9 抑制剂

Z-LEHD-FMK是一种不可逆抑制caspase-9和相关caspase活性的合成肽。了解更多

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- Wenquan Liang, .et al. Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species, Sci Rep, 2016, 6: 38267 PMID: 27905569
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K252a

Catalog No. A13897
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CaMK/Phosphorylase 抑制剂

K252a是CaM激酶和磷酸化酶激酶的高效细胞渗透抑制剂（IC50分别为1.8和1.7 nmol/L）。了解更多

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LMK-235

Catalog No. A14341
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HDAC4/5 抑制剂

LMK-235是选择性组蛋白脱乙酰基酶(HDAC) 4和HDAC5抑制剂。了解更多

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MK 8742 (elbasvir)

Catalog No. A13965
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HCV NS5A 抑制剂

MK 8742 (elbasvir)是HCV NS5A抑制剂，是一种用于治疗HCV感染的全口服，无干扰素的治疗方案。了解更多

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Z-FA-FMK

Catalog No. A14284
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Irreversible Cysteine Protease 抑制剂

Z-FA-FMK是不可逆的半胱氨酸蛋白酶抑制剂。了解更多

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XMD8-92

Catalog No. A11609
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BMK1/ERK5 抑制剂

XMD8-92是一种有效的选择性BMK1/ERK5抑制剂。了解更多

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KN-93 Phosphate

Catalog No. A14288
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CaMKII 抑制剂

KN-93 Phosphate是一种有效且特异性的Ca2+/钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，Ki为0.37μM，对APK，PKC，MLCK或Ca2+-PDE活性无明显抑制作用。了解更多

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- Kazuki Yuasa, .et al. Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy, Sci Rep, 2018, 8: 9037 PMID: 29899565
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Z-DEVD-FMK

Catalog No. A13503
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Caspase-3 抑制剂

Z-DEVD-FMK是一种特殊的不可逆的Caspase-3抑制剂。了解更多

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- Roi Ankawa, .et al. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration, Dev Cell, 2021, Jul 12;56(13):1900-1916 PMID: 34197726
- Yosefzon Y, .et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size, Mol Cell, 2018, May 17;70(4):573-587.e4 PMID: 29775577
- Akashi E, .et al. Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells, Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026
- Wenquan Liang, .et al. Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species, Sci Rep, 2016, 6: 38267 PMID: 27905569
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SL-327

Catalog No. A14137
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MKK/MEK 抑制剂

SL-327是MEK1和MEK2的选择性抑制剂（IC50值分别为0.18和0.22μM）；在体外阻断海马LTP。全身性给药后，体内的脑渗透剂会阻止大鼠的恐惧条件和学习，并在小鼠中产生神经保护作用。了解更多

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MK-3697

Catalog No. A12633
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OX2 拮抗剂

MK-3697是一种高效的，口服生物利用的选择性orexin 2受体拮抗剂，Ki值为0.95nM。了解更多

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Cambendazole

Catalog No. A13756
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Cambendazole用作驱赶恰加斯病的驱虫药。了解更多

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MK-8745

Catalog No. A13396
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Aurora Kinase A 抑制剂

MK-8745是一种新的极光特异性抑制剂。当在多种谱系的细胞系中进行体外试验时，它以p53依赖的方式诱导凋亡细胞死亡。了解更多

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Fosaprepitant dimeglumine

Catalog No. A11069
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neurokinin-1 receptor 拮抗剂

Fosaprepitant是一种选择性的神经激肽-1（NK-1）受体拮抗剂。了解更多

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CGP 57380

Catalog No. A13883
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MNK2 抑制剂

CGP 57380是MAP激酶相互作用激酶1（Mnk1，MKNK1）（IC50 = 2.2 uM）的抑制剂。了解更多

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Coluracetam

Catalog No. A13516
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Coluracetam (MKC-231)是一种新型胆碱吸收增强剂。了解更多

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MK 886

Catalog No. A13346
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leukotriene biosynthesis 抑制剂

MK-886是白三烯生物合成的抑制剂（人多形核白细胞中IC50 = 3 nM）。了解更多

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MK-3102

Catalog No. A13310
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DPP-4 抑制剂

Omarigliptin (MK-3102)是一种竞争性的、可逆的DPP-4抑制剂(IC50 = 1.6 nM, Ki = 0.8 nM)。在所有检测的蛋白酶中，包括QPP, FAP, PEP, DPP8和DPP9等，对DPP-4具有高选择性，具有微弱的离子通道活性（IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5）。了解更多

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Balamapimod (MKI-833)

Catalog No. A13119
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Ras/Raf/MEK 抑制剂

Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。了解更多

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MKT 077

Catalog No. A12388
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HSP70 抑制剂

MKT 077的p53结合位点，并使p53易位至细胞核。选择性细胞毒性；导致培养物中癌细胞生长停滞。也抑制端粒酶活性和交联f-肌动蛋白。了解更多

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MK7622

Catalog No. A12835
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M1 调节剂

MK7622是毒蕈碱M1受体阳性变构调节剂。了解更多

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Ibutamoren (MK-677)

Catalog No. A12802
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Ibutamoren，也称为MK-677（L-163,191），是一种有效的，口服活性的生长激素促分泌素，可模仿内源性生长激素释放素的GH刺激作用。了解更多

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Ibutamoren mesylate (MK-677)

Catalog No. A12781
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Ibutamoren mesylate (MK-677)是一种有效的，非肽段类生长激素促分泌素受体 (GHSR) 激动剂。了解更多

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SC-514

Catalog No. A12746
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IκB/IKK 抑制剂

SC-514是一种具有口服活性的，具有ATP竞争性的IKKβ抑制剂（IC50 = 3-12μM），其选择性是JNK，p38，MK2和ERK等28种其他激酶的10倍以上。了解更多

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Vorapaxar (SCH 530348)

Catalog No. A12832
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PAR-1 拮抗剂

Vorapaxar (SCH 530348)是一种有效的口服活性凝血酶受体（PAR-1）拮抗剂，Ki为8.1 nM。了解更多

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- Cansu Tekin, .et al. Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation, Cell Oncol (Dordr), 2020, Aug 18 PMID: 32809114
- Cansu Tekin, .et al. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer, Oncotarget, 2018, Aug 10; 9(62): 32010-32023 PMID: 30174793
- Claushuis TA, .et al. Thrombin contributes to protective immunity in pneumonia-derived sepsis via fibrin polymerization and platelet-neutrophil interactions, J Thromb Haemost, 2017, Apr;15(4):744-757 PMID: 28092405
- Maaike Waasdorp, .et al. Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner, Biochem Biophys Rep, 2017, Jul; 10: 152-156 PMID: 29114573
- Joseph C. Mudd, .et al. Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions, J Infect Dis, 2016, Dec 15; 214(12): 1808-1816 PMID: 27703039
- Corey E. Tabit, .et al. Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Non-Surgical Bleeding, Circulation, 2016, Jul 12; 134(2): 141-152 PMID: 27354285
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FMK

Catalog No. A11423
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RSK 抑制剂

FMK是p90核糖体蛋白S6激酶RSK1和RSK2的有效，高度特异性和不可逆的抑制剂。Fmk结合在CTKD ATP结合位点，并抑制Ser386处的RSK自磷酸化。Fmk诱导人类表达FGFR3的t（4; 14）阳性多发性骨髓瘤细胞发生明显凋亡。了解更多

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- Huang-Ming Chang, .et al. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling, Cell Death Dis, 2021, Apr 17;12(5):409 PMID: 33866326
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Z-VAD-FMK

Catalog No. A12373
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Pan Caspase 抑制剂

Z-VAD-FMK是一种细胞可渗透、不可逆的泛胱天蛋白酶抑制剂。体外抑制肿瘤细胞caspase加工和凋亡诱导(IC50 = 0.0015 - 5.8 mM)。活跃在体内。了解更多

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- Ming-Chun Hung, .et al. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer, Cell Biosci, 2022, 12: 122 PMID: 35918763
- Kaori Kanemaru, .et al. Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics, Nat Commun, 2022, May 9;13(1):2347 PMID: 35534464
- Chie Ishikawa, .et al. Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia, Invest New Drugs, 2022, Aug;40(4):718-727 PMID: 35477814
- Aida Falgas, .et al. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4 + lymphoma cells without toxicity in immunocompromised and immunocompetent mice, Biomed Pharmacother, 2022, Jun;150:112940 PMID: 35421785
- Sumire Suzuki, .et al. Lysosome-targeted drug combination induces multiple organelle dysfunctions and non?canonical death in pancreatic cancer cells, Oncol Rep, 2022, Feb;47(2):40 PMID: 34958115
- Lina Y Abou Zeid, .et al. Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression, Cell Stress Chaperones, 2022, Jan;27(1):11-25 PMID: 34719748
- Kosar Jabbari, .et al. Protein Ligands in the Secretome of CD36+ Fibroblasts Induce Growth Suppression in a Subset of Breast Cancer Cell Lines, Cancers (Basel), 2021, Sep 8;13(18):4521 PMID: 34572749
- Xiaoyue Deng, .et al. Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1, Invest Ophthalmol Vis Sci, 2021, May 3;62(6):1 PMID: 33938913
- Liqun Zhao, .et al. Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli, Apoptosis, 2021, Apr 27 PMID: 33905036
- Sofia Giacosa, .et al. Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction, Cancers (Basel), 2021, Feb 2;13(3):576 PMID: 33540838
- Hannes Schmid, .et al. Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells, Haematologica, 2021, Jan 14 PMID: 33440919
- Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
- El-Ashmawy NE, .et al. Modulatory Effect of Silymarin on Apoptosis in Testosterone -Induced Benign Prostatic Hyperplasia in Rats, Pathol Oncol Res, 2020, Jan 4 PMID: 31902118
- Schneider D, .et al. The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells, Clin Epigenetics, 2019, Jul 2;11(1):98 PMID: 31266541
- Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
- T Yamamoto, .et al. Mycoplasma pneumoniae protects infected epithelial cells from hydrogen peroxide-induced cell detachment, Cell Microbiol, 2019, 2019 PMID: 30702185
- Maeda N, .et al. Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells, J Biol Chem, 2019, Nov 13. pii: jbc.RA119.010379 PMID: 31723031
- Miyazawa S, .et al. Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines, Breast Cancer, 2019, Oct 17 PMID: 31625014
- Yeh HT, .et al. Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells, Eur J Pharmacol, 2019, Sep 10;863:172658 PMID: 31518562
- D. Bosc, .et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B, Sci Rep, 2018, 8: 11653 PMID: 30076329
- Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKε-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
- Hiroshi Kuribayashi, .et al. Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation, Cell Death Dis, 2018, Sep; 9(9): 891 PMID: 30166529
- Matsuo J, .et al. Activation of caspase-3 during Chlamydia trachomatis-induced apoptosis at a late stage, Can J Microbiol, 2018, Oct 18:1-9 PMID: 30336068
- Orly Ravid, .et al. Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties, Front Cell Neurosci, 2018, 12: 359 PMID: 30459557
- Im E, .et al. Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells, Life Sci, 2018, Sep 15;209:259-266 PMID: 30107166
- Szalai P, .et al. Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death, Cell Calcium, 2018, Dec;76:48-61 PMID: 30261424
- Im E, .et al. Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells, Life Sci, 2018, Jan 1;192:286-292 PMID: 29128513
- Iriyama N, .et al. The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells, Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692
- Birte Plitzko, .et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620
- Akashi E, .et al. Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells, Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026
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MK-0679 (Verlukast)

Catalog No. A11607
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LTD4 receptor 拮抗剂

MK-0679 (Verlukast)是有效的白三烯D4拮抗剂。了解更多

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MK-4305 (Suvorexant)

Catalog No. A11500
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OX receptor 拮抗剂

Suvorexant (MK-4305)是OX1R和OX2R的有效，选择性和口服可生物利用的拮抗剂，目前正在临床研究中作为失眠的新疗法。了解更多

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- Richard L Spinieli, .et al. Orexin contributes to eupnea within a critical period of postnatal development, Am J Physiol Regul Integr Comp Physiol, 2021, Oct 1;321(4):R558-R571 PMID: 34405704
- Jacob W Clark, .et al. Manipulation of REM sleep via orexin and GABAA receptor modulators differentially affects fear extinction in mice: effect of stable versus disrupted circadian rhythm, Sleep, 2021, Mar 15;zsab068 PMID: 33720375
- Zhang B, .et al. Hypothalamic orexin and mechanistic target of rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex, Neurobiol Dis, 2019, Oct 9;134:104615 PMID: 31605778
- Obara K, .et al. Assessment of Inhibitory Effects of Hypnotics on Acetylcholine-Induced Contractions in Isolated Rat Urinary Bladder Smooth Muscle, Biol Pharm Bull, 2019, 42(2):280-288 PMID: 30713259
- James B Jaggard, .et al. Hypocretin underlies the evolution of sleep loss in the Mexican cavefish, eLife, 2018, 7: e32637 PMID: 29405117
- Skillman B, .et al. Quantification of suvorexant in blood using liquid chromatography-quadrupole/time of flight (LC-Q/TOF) mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 2018, Aug 1;1091:87-95 PMID: 29859493
- Clark L, .et al. On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies, J Biomol NMR, 2018, Aug;71(4):203-211 PMID: 30121871
- Sullinger S, .et al. Identification of Suvorexant in Urine Using Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry (LC-Q/TOF-MS), J Anal Toxicol, 2017, Apr 1;41(3):224-229 PMID: 28035034
- Carson M, .et al. Quantification of suvorexant in urine using gas chromatography/mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 2017, Jan 1;1040:289-294 PMID: 27825624
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MK-2894

Catalog No. A11497
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EP4 receptor 拮抗剂

MK-2894是一种高度有效和选择性的第二代EP4拮抗剂。了解更多

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MK 0893

Catalog No. A11495
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GCGR 抑制剂

MK 0893是胰高血糖素受体拮抗剂作为抗糖尿病药物，IC50 值为 6.6 nM。了解更多

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Doravirine (MK-1439)

Catalog No. A12443
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NNRT 抑制剂

MK-1439是非核苷逆转录酶抑制剂。了解更多

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MK-0517 (Fosaprepitant)

Catalog No. A11756
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neurokinin-1 receptor 拮抗剂

MK-0517 (Fosaprepitant,L-758,298)是Aprepitant的水溶性磷酰基前药，它是NK1拮抗剂。了解更多

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Staurosporine

Catalog No. A10864
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PKC 抑制剂

Staurosporine是一种天然产物，最初于1977年从Streptomyces staurosporeus细菌中分离出来。星形孢菌素的主要生物学活性是通过防止ATP与激酶的结合来抑制蛋白激酶。是一种有效的PKC抑制剂，在无细胞试验中作用于PKCα，PKCγ 和PKCη，IC50分别为2 nM，5 nM 和 4 nM，对PKCδ(20 nM)和PKCε(73 nM作用较弱，对PKCζ (1086 nM)的活性很低。同时对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。了解更多

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- Lisa M Kim, .et al. Sustained Oncogenic Signaling in the Cytostatic State Enables Targeting of Nonproliferating Persistent Cancer Cells, Cancer Res, 2022, Sep 2;82(17):3045-3057 PMID: 35792658
- Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
- Birte Plitzko, .et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620
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KN-62

Catalog No. A11473
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CaM kinase II 抑制剂

KN-62是一种有效，选择性的钙调蛋白依赖性蛋白激酶 II (CaMK-II)抑制剂。了解更多

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Laropiprant (MK0524)

Catalog No. A11483
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DP1 抑制剂

Laropiprant (MK0524)与烟酸合用可降低血液胆固醇。是一种有效的，选择性的 DP receptor 拮抗剂，Ki 值为 0.57 nM，对 TP 受体的 Ki 值为 2.95 nM。了解更多

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Azilsartan (TAK-536)

Catalog No. A11775
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AT1 Receptor Blocker

Azilsartan (TAK-536)是一种用于治疗高血压的血管紧张素II受体拮抗剂。了解更多

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MK-2461

Catalog No. A11753
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c-Met 抑制剂

MK-2461是一种新型的多靶点激酶抑制剂，优先抑制活化的c-Met受体。了解更多

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Amiloride HCl

Catalog No. A10064
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Na+ channel blocker

Amiloride HCl是一种Na+通道阻滞剂，还抑制TRPP3通道和Na+/H+交换剂（NHE）。了解更多

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- Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986
- Thomas D. Williams, .et al. The physiological regulation of macropinocytosis during Dictyostelium growth and development, J Cell Sci, 2018, Mar 15; 131(6): jcs213736 PMID: 29440238
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Odanacatib (MK-0822)

Catalog No. A11265
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Cathepsin K 抑制剂

Odanacatib (MK-0822)是组织蛋白酶K（一种参与骨吸收的酶）的抑制剂。了解更多

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MK-0974 (Telcagepant)

Catalog No. A11255
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CGRP receptor 拮抗剂

MK-0974 (Telcagepant)是人和恒河猴CGRP受体的有效和选择性拮抗剂。了解更多

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Alendronate sodium hydrate

Catalog No. A10050
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Alendronate sodium hydrate是一种含氮的双膦酸盐，通常用于治疗骨质疏松症和其他代谢性骨疾病。了解更多

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MK 3207 HCl

Catalog No. A10598
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CGRP Receptor 拮抗剂

MK 3207 hydrochloride是一种有效的CGRP受体拮抗剂，IC50为0.12 nM。了解更多

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- Marlene Dallmayer, .et al. Targeting the CALCB/RAMP1-axis inhibits growth of Ewing sarcoma, bioRxiv, 2018, 2018
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Deforolimus (Ridaforolimus)

Catalog No. A10295
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mTOR 抑制剂

Deforolimus (Ridaforolimus)是mTOR蛋白的研究目标靶向小分子抑制剂。阻断mTOR通过干扰细胞生长，分裂，代谢和血管生成，在癌细胞中产生饥饿样的效应。了解更多

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MK-0812

Catalog No. A11127
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CCR2 拮抗剂

MK-0812是一种有效的选择性CCR2拮抗剂，对人单核细胞上CCR2的亲和力低，而在趋化性测定中的亲和力却低。它在临床前物种中具有良好的PK分布，并在动物模型中证明了功效。了解更多

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- Murakami K, .et al. CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis, Vet Immunol Immunopathol, 2016, Dec;182:52-58 PMID: 27863550

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