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￥ 0.00 Angiogenesis
Angiogenesis is the formation and remodelling of new blood vessels and capillaries from growth of pre-existing blood vessels. It normally occurs during wound healing and embryonic development, but is also required for tumour growth and metastasis in cancer.
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GDC-0834
Catalog No. A21243 -
Tirabrutinib
Catalog No. A21019 BTK inhibitorTirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. 了解更多 -
PCI-32765 (Ibrutinib)
Catalog No. A11020 Bruton tyrosine kinase 抑制剂PCI-32765 (Ibrutinib)是Bruton酪氨酸激酶（BTK）的口服生物利用小分子抑制剂，具有潜在的抗肿瘤活性。对Bmx，CSK，FGR，BRK及HCK适度有效，对EGFR，Yes，ErbB2，JAK3等作用效果较弱。 了解更多 -
CGI1746
Catalog No. A11348 -
GDC-0834 Racemate
Catalog No. A12706 -
AVL-292 benzenesulfonate
Catalog No. A15008 BTK 抑制剂AVL-292 benzenesulfonate是一种共价，高选择性，口服活性的Btk小分子抑制剂，IC50值为0.5 nM，选择性是其他测定激酶的1400倍以上。 了解更多 -
ACP-196 (Acalabrutinib)
Catalog No. A15824 Btk 抑制剂ACP-196是Bruton酪氨酸激酶（BTK）抑制剂，具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体（BCR）信号传导途径的激活。 了解更多 -
BMS-935177
Catalog No. A16905 -
Vecabrutinib
Catalog No. A17189 -
PF-06250112
Catalog No. A18612 BTK 抑制剂PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. 了解更多 -
PF-04554878 (Defactinib)
Catalog No. A11929 FAK 抑制剂PF-04554878 (Defactinib)是一种新型FAK激酶抑制剂，可降低胰腺神经内分泌肿瘤细胞的生长并诱导其凋亡。 了解更多 -
NVP-TAE 226
Catalog No. A11507 FAK 抑制剂NVP-TAE 226是一种强效FAK抑制剂，IC50为5.5 nM，对pyk2(IC50=3.5 nM)有适度的强效作用；对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。 了解更多 -
GSK2256098
Catalog No. A15765 -
PROTAC FAK degrader 1
Catalog No. A18946 FAK degraderPROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. 了解更多 -
Defactinib
Catalog No. A21958 FAK inhibitorDefactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. 了解更多 -
Defactinib hydrochloride
Catalog No. A22003 FAK inhibitorDefactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 了解更多 -
PF-03814735
Catalog No. A11171 Aurora A/B Kinase 抑制剂PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。 了解更多 -
PF-00562271
Catalog No. A12580 FAK 抑制剂PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK和Pyk2抑制剂，IC50分别为1.5 nM和14 nM。 了解更多 -
PF-4618433
Catalog No. A13461 -
R788 (Fostamatinib)
Catalog No. A11926 Syk 抑制剂R788 (Fostamatinib)是重要的脾酪氨酸激酶（Syk）抑制剂，显示出对激酶介导的IgG Fcγ受体信号转导的功效。 了解更多 -
BAY 61-3606
Catalog No. A11320 Syk 抑制剂BAY 61-3606是一种细胞可渗透的咪唑并嘧啶化合物，可作为Syk酪氨酸激酶活性的有效，ATP竞争性，可逆和高度选择性抑制剂，而对Btk，Fyn，Itk，Lyn和Src无抑制作用。 了解更多 -
P505-15 (PRT062607, BIIB057)
Catalog No. A11952 Syk 抑制剂P505-15 (PRT062607,BIIB057)是一种新型的，高度选择性的，Syk抑制剂（SYK IC（50）= 1 nM），具有比SYK活性至少高80倍的抗SYK活性。 了解更多 -
PRT 062070 (Cerdulatinib)
Catalog No. A14147 Dual Syk and JAK 抑制剂PRT 062070 (Cerdulatinib)是一种新型的口服双脾酪氨酸激酶（Syk）和janus激酶（JAK）抑制剂。Cerdulatinib优先抑制各种细胞类型中JAK1和JAK3依赖性细胞因子介导的信号传导和功能性反应。 了解更多 -
BAY 61-3606 dihydrochloride
Catalog No. A15017 -
R112
Catalog No. A14161 -
Lanraplenib
Catalog No. A12959 SYK inhibitorLanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. 了解更多 -
Fostamatinib disodium hexahydrate
Catalog No. A21873 Syk inhibitorFostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. 了解更多 -
TAK-659 hydrochloride
Catalog No. A21885 Syk inhibitorTAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. 了解更多 -
R935788 (Fostamatinib disodium, R788)
Catalog No. A10771 Syk 抑制剂R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂，可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。 了解更多 -
Piceatannol
Catalog No. A12162 -
GS-9973 (Entospletinib)
Catalog No. A13884 -
PRT062607 HCL
Catalog No. A12731 Syk 抑制剂PRT2607，也称为PRT062607，P505-15和BIIB057，是一种新型，高度选择性且口服可生物利用的小分子SYK抑制剂（SYK IC（50）= 1 nM），具有至少80倍的抗SYK活性 大于对其他激酶的亲和力。 了解更多 -
Gusacitinib
Catalog No. A19883 SYK/JAK inhibitorGusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM. 了解更多 -
Dasatinib (BMS-354825)
Catalog No. A10290 Abl-Src 抑制剂Dasatinib (BMS-354825)是一种口服多BCR/ABL和Src家族酪氨酸激酶抑制剂。Dasatinib (BMS-354825)的主要靶标是BCR/ABL，Src，c-Kit，ephrin受体和其他几种酪氨酸激酶，但不是erbB激酶，例如EGFR或Her2。 了解更多
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- EGFR (23)
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