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Cell Cycle

产品 151 到 200 共 257个

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  1. CDK9 inhibitor 2
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    CDK9 inhibitor 2

    Catalog No. A15039
    CDK9 抑制剂
    CDK9 inhibitor 2 是一种新型的细胞周期蛋白依赖性激酶9（CDK9）抑制剂。 了解更多
  2. AT7519 trifluoroacetate
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    AT7519 trifluoroacetate

    Catalog No. A15005
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    CDK 抑制剂
    AT7519 trifluoroacetate是CDK1、2、4、6和9的多CDK抑制剂，IC50为10-210 nM，对CDK3的效力较低，对CDK7的活性较低。 了解更多
  3. NG52
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    NG52

    Catalog No. A12494
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    Cell cycle-regulating kinase 抑制剂
    NG52 (Compound 52)是细胞周期调节激酶Cdc28p（IC50 = 7 μM）和相关Pho85p激酶（IC50 = 2 μM）的有效，可渗透细胞，可逆，选择性和ATP兼容的抑制剂。 了解更多
  4. LY2857785
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    LY2857785

    Catalog No. A15823
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    CDK9 抑制剂
    LY2857785是一种有效的选择性CDK9抑制剂。显着降低RNA聚合酶II CTD的磷酸化并显着降低MCL1蛋白水平，从而导致多种白血病和实体瘤细胞系发生凋亡。 了解更多
  5. RGB-286638
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    RGB-286638

    Catalog No. A13130
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    CDK 抑制剂
    RGB-286638是一种新型CDK抑制剂，对于细胞周期蛋白T1-CDK9/细胞周期蛋白B1-CDK1/细胞周期蛋白E-CDK2/细胞周期蛋白D1-CDK4/细胞周期蛋白E-CDK3的IC50为1 nM/2 nM/3 nM/4 nM/5 nM/p35-CDK5分别；对细胞周期蛋白H-CDK7和细胞周期蛋白D3-CDK6的效力较低。 了解更多
  6. ON123300
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    ON123300

    Catalog No. A12584
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    CDK4 抑制剂?
    ON123300是一种有效的多激酶抑制剂，对CDK4, Ark5, PDGFRβ, FGFR1, RET, Fyn的IC50分别为3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM和11nM，可能对脑肿瘤化学治疗有用。ON123300强烈抑制Ark5和CDK4，以及生长因子受体酪氨酸激酶，如β-型血小板衍生的生长因子受体（PDGFRβ）。 了解更多
  7. K03861
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    K03861

    Catalog No. A15889
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    CDK 抑制剂
    K03861是II型CDK2抑制剂，其CDK2（WT），CDK2（C118L），CDK2（A144C）和CDK2（C118L/A144C）的Kd分别为50 nM，18.6 nM，15.4 nM和9.7 nM。 了解更多
  8. Bohemine
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    Bohemine

    Catalog No. A15942
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    CDK 抑制剂
    Bohemine是一种有效且选择性的，细胞可渗透的，细胞周期蛋白依赖性激酶（CDK）抑制剂，IC50 = 1，M。 了解更多
  9. LY-3177833
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    LY-3177833

    Catalog No. A16325
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    CDC7 抑制剂
    LY-3177833是CDC7（细胞分裂循环7相关蛋白激酶）的有效和选择性抑制剂。 了解更多
  10. LY2835219 methanesulfonate
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    LY2835219 methanesulfonate

    Catalog No. A16386
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    CDK4/6 抑制剂
    LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。 了解更多
  11. SB1317 (TG02)
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    SB1317 (TG02)

    Catalog No. A13454
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    CDK/JAK2/FLT3 抑制剂
    SB1317是细胞周期蛋白依赖性激酶（CDKs）、类FMS酪氨酸激酶-3（FLT3）和Janus激酶2（JAK2）的有效抑制剂，CDK2、JAK2和FLT3的IC50值分别为13nM、56nM和73nM。 了解更多
  12. Atuveciclib (BAY-1143572)
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    Atuveciclib (BAY-1143572)

    Catalog No. A16810
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    Selective PTEFb/CDK9 抑制剂
    Atuveciclib (BAY-1143572)是目前处于I期的PTEFb/CDK9的高度选择性，有效且可口服的抑制剂。 了解更多
  13. ICEC0942 HCl
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    ICEC0942 HCl

    Catalog No. A16903
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    CDK7 抑制剂
    ICEC0942 HCl，也称为CT7001，是CDK7的口服生物利用选择性抑制剂。它选择性抑制CDK7，IC50为40nM。CDK1，CDK2，CDK5和CDK9的IC50值分别高45倍，15倍，230倍和30倍。 了解更多
  14. PF-06873600
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    PF-06873600

    Catalog No. A16875
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    CDK 抑制剂
    PF-06873600是一种口服生物利用型，细胞周期蛋白依赖性激酶（CDK）抑制剂，其对 CDK2、CDK4和CDK6的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM。具有潜在的抗肿瘤活性。 了解更多
  15. SEL120-34A
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    SEL120-34A

    Catalog No. A17086
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    CDK8 抑制剂
    SEL120-34A是一种有效且选择性的CDK8抑制剂，在AML细胞中具有高水平的STAT1和STAT5反式激活域丝氨酸磷酸化活性。 了解更多
  16. Trilaciclib
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    Trilaciclib

    Catalog No. A17084
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    CDK4/6 抑制剂
    Trilaciclib是潜在的一流的短效CDK4/6抑制剂，正在开发中，可在化学疗法中保存造血干细胞并增强免疫系统功能。 了解更多
  17. THZ531
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    THZ531

    Catalog No. A17036
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    CDK12 and CDK13 covalent 抑制剂
    THZ531是CDK12和CDK13共价抑制剂。THZ531不可逆地靶向位于激酶结构域外部的半胱氨酸。THZ531导致基因表达缺失，同时延伸和过度磷酸化RNA聚合酶II缺失。 了解更多
  18. BAY-1251152
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    BAY-1251152

    Catalog No. A17029
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    CDK9 抑制剂
    BAY-1251152，也称为(+)-BAY-1251152，是CDK9抑制剂。 了解更多
  19. NVP-2
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    NVP-2

    Catalog No. A17022
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    CDK9 抑制剂
    NVP-2是一种有效的选择性ATP竞争性CDK9抑制剂，IC50值为0.5 nM。 了解更多
  20. AZD4573
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    AZD4573

    Catalog No. A18321
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    CDK9 inhibitor
    AZD4573 is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. 了解更多
  21. Lerociclib (G1T38)
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    Lerociclib (G1T38)

    Catalog No. A18320
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    CDK inhibitor
    Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多
  22. MC180295
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    MC180295

    Catalog No. A18892
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    CDK9 inhibitor
    MC180295 is a highly selective CDK9 inhibitor (IC50 = 5 nM). MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect. 了解更多
  23. BI-1347
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    BI-1347

    Catalog No. A18769
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    CDK8 inhibitor
    BI-1347 is a selective inhibitor of CDK8/cyclin C with an IC50 of 1.1 nM. 了解更多
  24. CDK4/6-IN-2
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    CDK4/6-IN-2

    Catalog No. A18657
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    CDK4/CDK6 inhibitor
    CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively. 了解更多
  25. bio-THZ1
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    bio-THZ1

    Catalog No. A18559
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    covalent CDK7 inhibitor
    bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. 了解更多
  26. SY-1365
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    SY-1365

    Catalog No. A18482
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    CDK7 inhibitor
    SY-1365 is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. 了解更多
  27. THAL-SNS-032
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    THAL-SNS-032

    Catalog No. A19088
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    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
  28. FMF-04-159-2
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    FMF-04-159-2

    Catalog No. A18911
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    CDK14 inhibitor
    FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. 了解更多
  29. CDK2-IN-4
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    CDK2-IN-4

    Catalog No. A18667
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    CDK2 inhibitor
    CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM). 了解更多
  30. Abemaciclib Metabolites M2
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    Abemaciclib Metabolites M2

    Catalog No. A18416
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    CDK4/CDK6 inhibitor
    Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多
  31. MSC2530818
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    MSC2530818

    Catalog No. A12644
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    CDK8 inhibitor
    MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. 了解更多
  32. FN-1501
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    FN-1501

    Catalog No. A13559
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    FLT3/CDK inhibitor
    FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. 了解更多
  33. Ca2+ channel agonist 1
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    Ca2+ channel agonist 1

    Catalog No. A12186
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    Ca2+ channel agonist/CDK2 inhibitor
    Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. 了解更多
  34. P276-00
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    P276-00

    Catalog No. A13547
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    CDK 抑制剂
    P276-00是一种新型CDK1，CDK4和CDK9抑制剂，IC50分别为79 nM，63 nM和20 nM。在第2/3阶段。 了解更多
  35. LEE011 (Ribociclib)
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    LEE011 (Ribociclib)

    Catalog No. A13549
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    CDK4/6 抑制剂
    LEE011 (Ribociclib)是一种可口服的细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向细胞周期蛋白D1/CDK4和细胞周期蛋白D3/CDK6细胞周期途径，具有潜在的抗肿瘤活性。 了解更多
  36. LDC000067
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    LDC000067

    Catalog No. A14273
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    CDK 抑制剂
    LDC000067是一种高选择性CDK9抑制剂。 了解更多
  37. AMG-925
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    AMG-925

    Catalog No. A14025
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    Dual FLT3/CDK4 抑制剂
    AMG-925是一种有效，选择性和生物利用性的FLT3/细胞周期蛋白依赖性激酶4（CDK4）双激酶抑制剂。 了解更多
  38. CVT-313
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    CVT-313

    Catalog No. A15054
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    CDK2 抑制剂
    CVT-313是一种有效，选择性，可逆且具有ATP竞争性的CDK2抑制剂（对于Cdk2/A和Cdk2/E，IC50 = 0.5 uM；对于Cdk1/B为4.2 uM；对于Cdk4/D1为215 uM）。 了解更多
  39. Purvalanol A
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    Purvalanol A

    Catalog No. A15517
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    CDK 抑制剂
    Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶（cdk）抑制剂。对于cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35，IC50值分别为4、70、35、850和75 nM。 了解更多
  40. NVP-LCQ195
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    NVP-LCQ195

    Catalog No. A15196
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    CDK 抑制剂
    NVP-LCQ195是CDK1，CDK2，CDK3和CDK5的小分子杂环抑制剂，IC50为1-42 nM。 了解更多
  41. AG-024322
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    AG-024322

    Catalog No. A15485
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    CDK 抑制剂
    AG-24322是第二代CDK抑制剂。AG-024322是有效的CDK1，CDK2和CDK4抑制剂，可在临床前模型中产生细胞周期停滞和抗肿瘤活性。 了解更多
  42. NU2058
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    NU2058

    Catalog No. A15767
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    CDK 抑制剂
    NU2058是基于鸟嘌呤的CDK抑制剂，对CDK2和CDK1的IC50为17 uM和26 uM。 了解更多
  43. CDK8-IN-1
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    CDK8-IN-1

    Catalog No. A12961
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    CDK8 inhibitor
    CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. 了解更多
  44. CDK-IN-2
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    CDK-IN-2

    Catalog No. A11353
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    CDK9 inhibitor
    CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. 了解更多
  45. Senexin A
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    Senexin A

    Catalog No. A21166
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    CDK8 inhibitor
    Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. 了解更多
  46. Voruciclib hydrochloride
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    Voruciclib hydrochloride

    Catalog No. A21385
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    CDK inhibitor
    Voruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. 了解更多
  47. PHA-767491 hydrochloride
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    PHA-767491 hydrochloride

    Catalog No. A21395
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    dual Cdc7/Cdk9 inhibitor
    PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. 了解更多
  48. CDKI-73
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    CDKI-73

    Catalog No. A21467
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    CDK9 inhibitor
    CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). 了解更多
  49. CDK9-IN-1
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    CDK9-IN-1

    Catalog No. A21552
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    CDK9 inhibitor
    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87. 了解更多
  50. (±)-BAY-1251152
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    (±)-BAY-1251152

    Catalog No. A21564
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    PTEF/CDK9 inhibitor
    (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. 了解更多

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