Cell Metabolism

产品 251 到 300 共 394个

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  1. SW033291

    Catalog No. A15798
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    15-PGDH enzyme 抑制剂
    SW033291是15-PGDH的小分子抑制剂(Ki = 0.1 nM),可增加骨髓和其他组织中前列腺素PGE2的水平。 了解更多
  2. CKD-519

    Catalog No. A18873
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    CETP inhibitor
    CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. Single doses of CKD-519 up to 400 mg were well tolerated and showed potent inhibition of CETP activity. 了解更多
  3. CETP-IN-3

    Catalog No. A18878
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    CETP inhibitor
    CETP-IN-3 (Compound 13) is an small molecule inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP. 了解更多
  4. Anacetrapib (MK-0859)

    Catalog No. A11084
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    CETP 抑制剂
    Anacetrapib (MK-0859)是一种有效的,选择性,可逆的rhCETP和突变CETP(C13S)抑制剂,IC50分别为7.9 nM和11.8 nM,提高HDL-C,降低LDL-C,不提高醛固酮和血压。 了解更多
  5. JTT-705 (Dalcetrapib)

    Catalog No. A11213
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    CETP 抑制剂
    JTT-705 (Dalcetrapib)是一种CETP抑制剂,抑制CETP是增加HDL-胆固醇并可能减少动脉粥样硬化的目标。 了解更多
  6. Torcetrapib (CP-529414)

    Catalog No. A11242
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    CETP 抑制剂
    Torcetrapib (CP-529414)是一种CETP抑制剂,IC50为37 nM。 了解更多
  7. Evacetrapib (LY2484595)

    Catalog No. A11397
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    CETP 抑制剂
    Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂,IC50为5.5 nM,可在不增加醛固酮或血压的情况下升高HDL胆固醇。 了解更多
  8. UAMC-3203

    Catalog No. A20084
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    Ferroptosis inhibitor
    UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. 了解更多
  9. UAMC-3203 hydrochloride

    Catalog No. A21683
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    Ferroptosis inhibitor
    UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. 了解更多
  10. Ferrostatin-1 (Fer-1)

    Catalog No. A13247
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    ferroptosis 抑制剂
    Ferrostatin-1 (Fer-1)是一种有效的选择性铁锈病抑制剂,EC50为60 nM。 了解更多
  11. Erastin

    Catalog No. A13822
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    VDAC 抑制剂
    Erastin是一种细胞可渗透的哌嗪基-喹唑啉酮化合物,在具有H-Ras突变的细胞中表现出癌基因选择性致死性。 了解更多
  12. RSL3

    Catalog No. A15865
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    Ferroptosis inhibitor
    RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. 了解更多
  13. Clinofibrate

    Catalog No. A11184
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    HMG-CoA Reductase 抑制剂
    Clinofibrate是一种脂质清除剂,似乎可以改变脂质代谢,减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)(羟甲基戊二酰辅酶A还原酶),IC50为0.47 mM。 了解更多
  14. Rosuvastatin

    Catalog No. A11122
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    HMG-CoA reductase 抑制剂
    Rosuvastatin是用于治疗高胆固醇和相关疾病的抑制剂。 了解更多
  15. 2-Hydroxy atorvastatin calcium salt

    Catalog No. A18971
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    HMG-CoA reductase inhibitor
    2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. 了解更多
  16. Simvastatin

    Catalog No. A10845
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    HMG-CoA reductase inhibitor
    Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. 了解更多
  17. Fluvastatin sodium

    Catalog No. A10403
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    HMG-CoA reductase inhibitor
    Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多
  18. Fluvastatin

    Catalog No. A21232
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    HMG-CoA reductase inhibitor
    Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多
  19. Rosuvastatin calcium (Crestor)

    Catalog No. A10810
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    HMG-CoA reductase 抑制剂
    Rosuvastatin calcium (Crestor)是他汀类药物中的一员,用于治疗高胆固醇及相关疾病,并预防心血管疾病。罗苏伐他汀是一种竞争性HMG-CoA reductase抑制剂,无细胞试验中IC50为11 nM。 了解更多
  20. Pravastatin sodium

    Catalog No. A11912
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    HMG-CoA reductase 抑制剂
    Pravastatin sodium是3-羟基-3-甲基辅酶A(HMG-CoA)还原酶的水溶性竞争性抑制剂。有效阻断体内胆固醇合成(Ki?1 nM)并显示出心脏保护特性。 了解更多
  21. Atorvastatin calcium

    Catalog No. A11800
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    HMG-CoA reductase 抑制剂
    Atorvastatin calcium (Lipitor)是HMG-CoA还原酶的抑制剂,可用作降低胆固醇的药物,可阻止胆固醇的产生。 了解更多
  22. Pitavastatin calcium (Livalo)

    Catalog No. A10737
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    HMG-CoA reductase 抑制剂
    Pitavastatin calcium (Livalo)是HMGCR(HMG-CoA还原酶)酶的竞争性抑制剂,可降低LDL胆固醇的合成。 了解更多
  23. Lovastatin (Mevacor)

    Catalog No. A11877
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    HMG-CoA reductase 抑制剂
    Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂,IC50为3.4 nM,用于降低胆固醇。 了解更多
  24. Swertiamarin

    Catalog No. A12128
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    HMG-CoA reductase 抑制剂
    Swertiamarin通过抑制高胆固醇喂养大鼠的HMG-CoA还原酶活性显示出作为抗动脉粥样硬化剂的潜力。 了解更多
  25. Mevastatin

    Catalog No. A13709
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    HMG-CoA reductase 抑制剂
    Mevastatin是HMG-CoA还原酶的抑制剂。 了解更多
  26. Atorvastatin

    Catalog No. A13743
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    HMG-CoA reductase 抑制剂
    Atorvastatin是一种HMG-CoA还原酶抑制剂(IC50 = 154 nM),可有效治疗高胆固醇血症和某些血脂异常。 了解更多
  27. Pitavastatin Lactone

    Catalog No. A13896
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    HMG-CoA reductase 抑制剂
    Pitavastatin Lactone是HMG-CoA还原酶抑制剂。 了解更多
  28. Mutant IDH1 inhibitor

    Catalog No. A21150
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    mutant IDH1 R132H inhibitor
    Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM. 了解更多
  29. Mutant IDH1-IN-2

    Catalog No. A21339
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    IDH inhibitor
    Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. 了解更多
  30. Mutant IDH1-IN-1

    Catalog No. A21359
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    mutant-selective IDH1 inhibitor
    Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. 了解更多
  31. AGI-5198 (IDH-C35)

    Catalog No. A12902
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    IDH1 抑制剂
    AGI-5198 (IDH-C35)是一种非常有效的选择性IDH1突变抑制剂,具有潜在的抗癌活性。 了解更多
  32. AGI-6780

    Catalog No. A12903
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    IDH2 R140Q 抑制剂
    AGI-6780是有效的选择性IDH2突变抑制剂,IC50值为23 nM。 了解更多
  33. IDH-C227

    Catalog No. A12923
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    IDH1 R132H 抑制剂
    IDH-C227是一种有效的选择性IDH1 R132H抑制剂。 了解更多
  34. Enasidenib

    Catalog No. A15808
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    IDH2 抑制剂
    Enasidenib是一种有效的选择性IDH2抑制剂,具有潜在的抗癌活性(IDH2 =异柠檬酸脱氢酶2)。 了解更多
  35. AG-120 (Ivosidenib)

    Catalog No. A14386
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    IDH1 抑制剂
    AG-120 (Ivosidenib)是1型异柠檬酸脱氢酶(IDH1)的口服抑制剂,具有潜在的抗肿瘤活性。 了解更多
  36. IDH-305

    Catalog No. A16943
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    IDH1 抑制剂
    IDH305是柠檬酸循环酶异柠檬酸脱氢酶[NADP]细胞质的抑制剂(异柠檬酸脱氢酶1,IDH1),在残基R132(IDH1(R132))处具有突变,具有潜在的抗肿瘤活性。 了解更多
  37. Vorasidenib

    Catalog No. A16908
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    IDH1 抑制剂
    Vorasidenib (AG-881)是一种有效且选择性的口服抑制剂,可抑制细胞质中异柠檬酸脱氢酶1型(IDH1,IDH1 [NADP+]可溶)和2型(IDH2异柠檬酸脱氢酶[NADP+])的突变形式。线粒体中的线粒体,具有潜在的抗肿瘤活性。 了解更多
  38. BAY-1436032

    Catalog No. A17059
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    mIDH1 抑制剂
    BAY-1436032是一种有效的,选择性的,口服的突变型异柠檬酸脱氢酶1(mIDH1)抑制剂。 了解更多
  39. Olutasidenib (FT-2102)

    Catalog No. A18789
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    IDH1 inhibitor
    Olutasidenib is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia. 了解更多
  40. Mutant IDH1-IN-4

    Catalog No. A19106
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    IDH1 inhibitor
    Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ?? 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells. 了解更多
  41. IDH1 Inhibitor 2

    Catalog No. A18420
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    IDH1 inhibitor
    DH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. 了解更多
  42. Epacadostat (INCB024360)

    Catalog No. A15554
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    IDO 抑制剂
    Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶(IDO1)抑制剂,第2期的IC50为10 nM。 了解更多
  43. IDO/TDO-IN-1

    Catalog No. A18566
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    IDO/TDO dual inhibitor
    IDO/TDO-IN-1 is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively . 了解更多
  44. IDO-IN-12

    Catalog No. A18988
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    IDO inhibitor
    IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1. 了解更多
  45. GNF-PF-3777

    Catalog No. A13507
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    hIDO2 inhibitor
    GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM. 了解更多
  46. IDO-IN-3

    Catalog No. A20898
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    IDO inhibitor
    IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM. 了解更多
  47. IDO-IN-5

    Catalog No. A21074
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    IDO inhibitor
    IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM. 了解更多
  48. IDO-IN-4

    Catalog No. A21077
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    IDO-1 inhibitor
    IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1. 了解更多
  49. IACS-8968 R-enantiomer

    Catalog No. A21555
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    dual IDO/TDO inhibitor
    IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多
  50. IACS-8968 S-enantiomer

    Catalog No. A21559
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    dual IDO/TDO inhibitor
    IACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多

产品 251 到 300 共 394个

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