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产品 1 到 50 共 64个

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  1. AZD-5991 S-enantiomer
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    AZD-5991 S-enantiomer

    Catalog No. A21361
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    Mcl-1 inhibitor
    AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay. 了解更多
  2. AZD-5991 Racemate
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    AZD-5991 Racemate

    Catalog No. A21357
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    Mcl-1 inhibitor
    AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay. 了解更多
  3. AZD-4320
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    AZD-4320

    Catalog No. A17171
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    Bcl-2/Bcl-XL 抑制剂
    AZD-4320是BH3模拟物和双重Bcl-2/Bcl-XL抑制剂。AZD4320 对于 KPUM-MS3，KPUM-UH1，和 STR-428 细胞系的 IC50 分别为 26 nM，17 nM，和 170 nM。 了解更多
  4. AZD-5904
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    AZD-5904

    Catalog No. A17062
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    MPO 抑制剂
    AZD-5904是一种有效的生物利用MPO抑制剂。在临床前研究中，AZD-5904以140 nM的IC50抑制了分离出的MPO酶，在大鼠和小鼠MPO酶活性的测定中具有大约等价性。 了解更多
  5. AZD-9291 (Osimertinib)
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    AZD-9291 (Osimertinib)

    Catalog No. A13681
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    EGFR 抑制剂
    AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。 了解更多
  6. AZD-2461
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    AZD-2461

    Catalog No. A12393
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    PARP 抑制剂
    AZD2461是新型有效的PARP抑制剂，对P-糖蛋白的亲和力较低。 了解更多
  7. AZD-7648
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    AZD-7648

    Catalog No. A20049
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    DNA-PK inhibitor
    AZD-7648 is a potent and selective DNA-PK inhibitor. Anti-tumor activity. 了解更多
  8. AZD-3965
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    AZD-3965

    Catalog No. A14186
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    MCT1 抑制剂
    AZD-3965（AZD3965）是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1（MCT1）的选择性抑制剂，是MCT2的6倍选择性，在10μM时不抑制MCT4。 了解更多
  9. AZD 7545
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    AZD 7545

    Catalog No. A14157
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    PDHK 抑制剂
    AZD7545是PDHK2的新型选择性小分子抑制剂（PDH激酶2），对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。 了解更多
  10. AZD 2932
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    AZD 2932

    Catalog No. A14156
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    mutil-targeted protein tyrosine kinase 抑制剂
    AZD2932是一种有效且靶向多用途的蛋白酪氨酸激酶抑制剂，对VEGFR-2，PDGFRβ，Flt-3和c-Kit的IC50分别为8 nM，4 nM，7 nM和9 nM。 了解更多
  11. Volitinib (Savolitinib, AZD-6094)
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    Volitinib (Savolitinib, AZD-6094)

    Catalog No. A14419
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    c-Met 抑制剂
    Volitinib (Savolitinib,AZD-6094)是c-Met受体酪氨酸激酶的生物利用抑制剂，具有潜在的抗肿瘤活性。 了解更多
  12. Cediranib maleate
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    Cediranib maleate

    Catalog No. A21857
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    VEGFR inhibitor
    Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. 了解更多
  13. AZD5991
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    AZD5991

    Catalog No. A16880
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    Mcl-1 抑制剂
    AZD-5991是一种有效的选择性Mcl-1抑制剂，在FRET分析中的IC50为0.7 nM，在表面等离子体共振（SPR）分析中的Kd为0.17 nM。 了解更多
  14. Elobixibat
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    Elobixibat

    Catalog No. A20984
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    (IBAT inhibitor
    Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ?? 0.17 nM, 0.13 ?? 0.03 nM, and 5.8 ?? 1.6 nM for human IBAT, mouse IBAT, and canine IBAT. 了解更多
  15. AZD5153 6-Hydroxy-2-naphthoic acid
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    AZD5153 6-Hydroxy-2-naphthoic acid

    Catalog No. A21852
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    BET/BRD4 bromodomain inhibitor
    AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. 了解更多
  16. AZD3839 free base
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    AZD3839 free base

    Catalog No. A21606
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    BACE1 inhibitor
    AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多
  17. AZD8329
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    AZD8329

    Catalog No. A21081
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    11β-HSD1 inhibitor
    AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3. 了解更多
  18. Lanabecestat
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    Lanabecestat

    Catalog No. A12282
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    BACE1 inhibitor
    Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多
  19. AZD3988
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    AZD3988

    Catalog No. A13208
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    DGAT-1 inhibitor
    AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively. 了解更多
  20. AZD9898
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    AZD9898

    Catalog No. A18959
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    LTC4S inhibitor
    AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma. 了解更多
  21. AZD4573
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    AZD4573

    Catalog No. A18321
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    CDK9 inhibitor
    AZD4573 is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. 了解更多
  22. AZD7986
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    AZD7986

    Catalog No. A17095
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    DPPI 抑制剂
    AZD7986，也称为INS 1007，是第二代可逆共价，有效和选择性DPP1抑制剂，潜在地可用于治疗慢性阻塞性肺疾病（COPD），其预测的人PK特性适用于每日一次人类给药。 了解更多
  23. AZD3229 Tosylate
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    AZD3229 Tosylate

    Catalog No. A16867
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    pan-KIT mutant 抑制剂
    AZD3229 Tosylate是一种有效的pan-KIT突变抑制剂，用于治疗胃肠道间质瘤。 了解更多
  24. AZD7507
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    AZD7507

    Catalog No. A16886
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    CSF-1R 抑制剂
    AZD7507是一种有效的选择性CSF-1R抑制剂（32 nM细胞活性），AZD7507被认为是一种很有前途的化合物，因为它保留了AZ683所需的效能和口服药代动力学特性。 了解更多
  25. AZD1208 HCl
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    AZD1208 HCl

    Catalog No. A16927
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    PIM kinases 抑制剂
    AZD1208 HCl是一种新型的，口服可生物利用的高选择性PIM激酶抑制剂。 了解更多
  26. AZD0364
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    AZD0364

    Catalog No. A16839
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    ERK 抑制剂
    AZD0364是一种临床前ERK1/2抑制剂，对ERK2的IC50为0.6 nM。 了解更多
  27. AZD1390
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    AZD1390

    Catalog No. A16798
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    ATM 抑制剂
    AZD1390是一流的口服中枢神经渗透性ATM抑制剂，在细胞中的IC50为0.78 nM，对PIKK酶家族中密切相关的成员具有10,000倍以上的选择性，并且在多种激酶中均具有出色的选择性。 了解更多
  28. AZD0156
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    AZD0156

    Catalog No. A16419
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    ATM 抑制剂
    AZD0156是有效且选择性的ATM激酶抑制剂，具有潜在的化学/放射致敏和抗肿瘤活性。 了解更多
  29. AZD8835
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    AZD8835

    Catalog No. A16352
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    PI3Kα/PI3Kδ 抑制剂
    AZD8835是一种有效的选择性PI3Kα和PI3Kδ抑制剂，IC50为5.7 nM和6.2 nM，对PI3Kβ（IC50 431 nM）和PI3Kγ（IC50 90 nM）具有选择性。 了解更多
  30. AZD3264
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    AZD3264

    Catalog No. A15900
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    IKK2 抑制剂?
    AZD3264是一种新型的IKK2抑制剂。 了解更多
  31. AZD6738 (Ceralasertib)
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    AZD6738 (Ceralasertib)

    Catalog No. A15794
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    ATR 抑制剂
    AZD6738是一种有效的ATR激酶抑制剂，对分离的酶的IC50为1 nM，对细胞中ATR激酶依赖性CHK1磷酸化的IC50为74 nM。 了解更多
  32. AZD8186
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    AZD8186

    Catalog No. A15759
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    PI3K 抑制剂
    AZD8186是一种同工型特异性小分子PI3K抑制剂，有效抑制PI3Kβ（IC50 = 4 nM）和PI3Kδ（IC50 = 12 nM），选择性高于PI3Kα（IC50 = 35 nM）和PI3Kγ（IC50 = 675 nM）。 了解更多
  33. AZD7687
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    AZD7687

    Catalog No. A15012
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    DGAT1 抑制剂
    AZD7687是一种有效的选择性DGAT1抑制剂，IC50值为80 nM（hDGAT1）。 了解更多
  34. AZD1152
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    AZD1152

    Catalog No. A15011
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    Aurora B 抑制剂
    AZD1152是一种前药，可在血清中迅速经历磷酸酶介导的裂解作用，释放出Barasertib-hQPA（一种选择性的Aurora B激酶抑制剂），在急性髓细胞性白血病（AML）患者的临床研究中显示出初步活性。 了解更多
  35. AZD4017
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    AZD4017

    Catalog No. A13542
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    HSD1 抑制剂
    AZD4017是一种有效的，选择性的，口服可生物利用的11b-HSD1抑制剂（11b-羟基类固醇脱氢酶1型抑制剂）。 了解更多
  36. AZD8186
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    AZD8186

    Catalog No. A14164
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    PI3K 抑制剂
    AZD8186是磷酸肌醇-3激酶(PI3K)β亚型的抑制剂，具有潜在的抗肿瘤活性。 了解更多
  37. AZD6642
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    AZD6642

    Catalog No. A14400
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    FLAP 抑制剂
    AZD6642是5-Lipoxygenase激活蛋白（FLAP）的抑制剂，可用于治疗炎症。 了解更多
  38. Alvelestat
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    Alvelestat

    Catalog No. A12779
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    neutrophil elastase 抑制剂
    Avelestat，也称为AZD9668，是可口服的,高度选择性neutrophil elastase (NE)抑制剂，IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。 了解更多
  39. AZD3463
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    AZD3463

    Catalog No. A13065
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    ALK/IGF1R 抑制剂
    AZD3463是ALK/IGF1R抑制剂。 了解更多
  40. AZD2858
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    AZD2858

    Catalog No. A13060
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    GSK-3β 抑制剂
    AZD2858是一种选择性GSK-3抑制剂，IC50为68 nM，激活Wnt信号，增加大鼠的骨量。 了解更多
  41. AZD1208
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    AZD1208

    Catalog No. A13203
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    pan-Pim kinase 抑制剂
    AZD1208是PIM激酶的小分子抑制剂，具有潜在的抗肿瘤活性。 了解更多
  42. AZD3514
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    AZD3514

    Catalog No. A12396
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    AR 抑制剂 downregulator
    AZD3514是一种有效的雄激素受体下调剂，具有潜在的抗癌活性。 了解更多
  43. AZD1080
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    AZD1080

    Catalog No. A12819
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    GSK3 抑制剂
    AZD1080是一种新型GSK3抑制剂，可消除啮齿动物大脑中的突触可塑性缺陷，并在人类中表现出外周靶标参与。 了解更多
  44. AZD3839
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    AZD3839

    Catalog No. A12825
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    BACE1 抑制剂
    AZD3839是人类BACE1的有效选择性抑制剂，Ki为26.1 nM。 了解更多
  45. AZD5363
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    AZD5363

    Catalog No. A11759
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    AKT 抑制剂
    AZD5363是有效的AKT抑制剂，在体内具有药效学活性，有潜力作为单一疗法或联合用药来治疗一系列实体瘤和血液肿瘤。 了解更多
  46. AZD3759
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    AZD3759

    Catalog No. A15551
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    EGFR 抑制剂
    AZD3759是表皮生长因子受体（EGFR）的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。 了解更多
  47. AZ5104
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    AZ5104

    Catalog No. A15516
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    EGFR 抑制剂
    AZD-9291的去甲基代谢产物AZ5104是一种有效的EGFR抑制剂，对于EGFR（L858R/T790M），EGFR（L858R），EGFR（L861Q）和EGFR，IC50 <1 nM，6 nM，1 nM和25 nM EGFR（野生型）。 了解更多
  48. AZD5597
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    AZD5597

    Catalog No. A13506
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    CDK 抑制剂
    AZD5597是有效的CDK抑制剂，对一系列癌细胞具有体外抗增殖作用。 了解更多
  49. AZD2014 (Vistusertib)
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    AZD2014 (Vistusertib)

    Catalog No. A11303
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    mTORC1/2 抑制剂
    Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。 了解更多
  50. AZD5438
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    AZD5438

    Catalog No. A11105
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    CDK 抑制剂
    AZD5438是有效的细胞周期蛋白依赖性激酶（CDK）1、2和9抑制剂（IC50值分别为16、6和20 nM）。 了解更多

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