HDAC

Catalog No.Inhibitor Name HDAC HDAC1 HDAC2 HDAC3 HDAC4HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2
A10979Vorinostat
****
A10611Entinostat
**
*
A10518Panobinostat
****
A10947Trichostatin A
****
A10586Mocetinostat
**
**
*
*
A10122Belinostat
***
A11920Romidepsin
***
***
A10560MC1568
*
A11042Tubastatin A HCl
*
***
A10488Givinostat
****
****
A10516Dacinostat
***
A10246CUDC-101
****
****
***
****
***
***
****
**
**
**
***
A10830Pracinostat
***
**
***
***
***
*
**
**
**
***
**
A11152PCI-34051
*
*
****
*
A10337Droxinostat
*
*
*
A10700Abexinostat
****
***
****
***
**
***
A13218RGFP966
**
A11037AR-42
***
A11940Ricolinostat
**
***
***
*
*
****
*
**
A11964Tacedinaline
*
*
*
**
A11153CUDC-907
****
****
****
**
*
***
**
**
****
****
A11355M344
**
A10954Tubacin
****
A13139RG2833
***
****
A12556Resminostat
***
***
**
A15489BRD73954
*
***
**
A11361BG45
*
*
**
A143544SC-202
*
*
*
A16431CAY10603
**
****
A14341LMK-235
***
****
A14032Nexturastat A
****
A14128TMP269
**
**
***
***
A14197HPOB
*
*
*
***
*
*
A12722Scriptaid
A12616Tasquinimod
A11042Tubastatin A
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 88个

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  1. MS-275 (Entinostat)

    Catalog No. A10611
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    HDAC 抑制剂
    MS-275 (Entinostat)是一种有效的HDAC抑制剂,对HDAC1和HDAC3的IC50分别为0.3和8uM。 了解更多
  2. Trichostatin-A (TSA)

    Catalog No. A10947
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    HDAC 抑制剂
    Trichostatin-A (TSA)是抑制HDAC 1、3、4、6和10,IC50值约为20 nM。 了解更多
  3. Belinostat (PXD101)

    Catalog No. A10122
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    HDAC 抑制剂
    Belinostat(PXD101)是一种HDAC抑制剂,可抑制HeLa细胞提取物中的HDAC活性,IC50为27 nM。 了解更多
  4. LBH589 (Panobinostat)

    Catalog No. A10518
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    HDAC 抑制剂
    LBH589是异羟肟酸,用作非选择性HDAC抑制剂,HDAC1的IC5o为0.23 nM。 了解更多
  5. MC1568

    Catalog No. A10560
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    HDAC 抑制剂
    MC1568是HDAC抑制剂的成员,它通过修饰细胞周期的各种重要基因的基因表达(主要在G1期)来抑制II类组蛋白脱乙酰基酶,从而导致细胞凋亡导致乳腺癌细胞死亡。 了解更多
  6. MGCD0103 (Mocetinostat)

    Catalog No. A10586
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    HDAC 抑制剂
    MGCD0103 (Mocetinostat)是一种苯甲酰胺组蛋白脱乙酰基酶抑制剂,主要抑制组蛋白脱乙酰基酶1(HDAC1),但也抑制HDAC2,HDAC3和HDAC11。 了解更多
  7. Vorinostat (SAHA)

    Catalog No. A10979
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    HDAC 抑制剂
    Vorinostat (SAHA)是HDAC的抑制剂,抑制脱乙酰和导致双方超乙酰化组蛋白和转录因子的积累。 了解更多
  8. AR-42 (HDAC-42)

    Catalog No. A11037
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    HDAC 抑制剂
    AR-42 (HDAC-42)是一种新型的HDAC抑制剂,通过下调本构激活的Kit表现出对恶性肥大细胞系的生物学活性。 了解更多
  9. SB939 ( Pracinostat )

    Catalog No. A10830
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    HDAC 抑制剂
    SB939 (Pracinostat)是HDAC的口服抑制剂,对I,II和IV类HDAC具有选择性,在体外HDAC1活性测定中显示IC50值为77 nM。 了解更多
  10. JNJ-26481585 (Quisinostat)

    Catalog No. A10492
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    HDAC 抑制剂
    JNJ-26481585 (Quisinostat)是一种pan-HDAC抑制剂,对HDAC1具有显著的效力(IC(50),0.16 nmol/L)。 了解更多
  11. CUDC-907 (Fimepinostat)

    Catalog No. A11153
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    PI3K/HDAC 抑制剂
    CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂,作用于PI3Kα和HDAC1/2/3/10,IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。 了解更多
  12. Romidepsin (FK228 ,Depsipeptide)

    Catalog No. A11920
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    HDAC 抑制剂
    Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2,IC50分别为1.6 nM和3.9 nM,但相对较弱地分别抑制HDAC4和HDAC6,IC50值为25 nM和79 nM。 了解更多
  13. TMP 269

    Catalog No. A14128
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    HDAC 抑制剂
    TMP 269是一种有效的选择性IIa类HDAC抑制剂,对HDAC4,HDAC5,HDAC7和HDAC9的IC50分别为157 nM,97 nM,43 nM和23 nM。 了解更多
  14. RG2833 (RGFP109)

    Catalog No. A13139
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    HDAC 抑制剂
    RG2833 (RGFP109)是一种脑渗透性HDAC抑制剂,IC50为60 nM,HDAC1和HDAC3为50 nM。 了解更多
  15. Resminostat hydrochloride

    Catalog No. A15220
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    HDAC 抑制剂
    Resminostat hydrochloride是HDAC1/3/6的有效抑制剂(IC50 = 43-72 nM);对HDAC8的效力较低,IC50为877 nM。 了解更多
  16. KD 5170

    Catalog No. A15354
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    HDAC 抑制剂
    KD 5170是一种新型的基于巯基酮的组蛋白脱乙酰基酶抑制剂,在体外和体内均表现出广谱的抗肿瘤活性。 了解更多
  17. NCH 51

    Catalog No. A15355
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    HDAC 抑制剂
    NCH 51是细胞可渗透的前药,可在细胞内转化为有效的HDAC抑制剂,IC50为48 nM。 了解更多
  18. NSC 3852

    Catalog No. A15356
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    HDAC 抑制剂
    NSC 3852是HDAC(组蛋白脱乙酰基酶)抑制剂。 了解更多
  19. TC-H 106

    Catalog No. A15357
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    HDAC 抑制剂
    TC-H 106是一种慢速,紧密结合的I类HDAC(组蛋白脱乙酰基酶)抑制剂。 了解更多
  20. TCS HDAC6 20b

    Catalog No. A15387
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    HDAC6 抑制剂
    TCS HDAC6 20b是组蛋白脱乙酰基酶6(HDAC6)的选择性抑制剂。与紫杉醇联合抑制HCT116的生长。还抑制雌激素刺激的MCF-7细胞的生长。 了解更多
  21. R306465

    Catalog No. A15437
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    HDAC 抑制剂
    R306465是一种新型的基于异羟肟酸酯的组蛋白脱乙酰基酶(HDAC)抑制剂,在临床前模型中具有针对实体和血液恶性肿瘤的广谱抗肿瘤活性。 了解更多
  22. Citarinostat (ACY-241)

    Catalog No. A12758
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    HDAC6 抑制剂
    ACY-241是HDAC6的新型,选择性和口服抑制剂。对HDAC6和HDAC3的IC50分别为2.6 nM和46 nM。 了解更多
  23. ACY-738

    Catalog No. A15934
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    HDAC6 抑制剂
    ACY-738是一种有效的选择性HDAC6抑制剂,具有改善的脑生物利用度。ACY-738抑制HDAC6的纳摩尔浓度低,选择性比I类HDAC高60到1500倍。 了解更多
  24. BML-210

    Catalog No. A15935
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    HDAC 抑制剂?
    BML-210是HDAC抑制剂。BML-210诱导宫颈癌细胞中的生长抑制和凋亡并调节HDAC和DAPC复合物的表达水平。 了解更多
  25. M344

    Catalog No. A11355
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    HDAC 抑制剂
    M344是HDAC的有效抑制剂,IC50为100 nM,能够诱导细胞分化。 了解更多
  26. BG45

    Catalog No. A11361
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    HDAC 抑制剂
    BG45是一种HDAC I类抑制剂,对HDAC3具有选择性(IC50 = 289 nM)。它抑制HDAC1,HDAC2和HDAC6的效力大大降低(IC50分别为2、2和> 20μM)。 了解更多
  27. ITSA-1

    Catalog No. A16127
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    HDAC 抑制剂
    ITSA-1具有膜渗透性,可以特异性抑制TSA对HDAC(组蛋白脱乙酰基酶)的抑制,但不能抑制其他HDAC抑制剂。 了解更多
  28. CRA-026440

    Catalog No. A12179
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    HDAC inhibitor
    CRA-026440 is a potent, broad-spectrum HDAC inhibitor. 了解更多
  29. Valproic acid sodium salt

    Catalog No. A10855
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    HDAC inhibitor
    Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. 了解更多
  30. JAK/HDAC-IN-1

    Catalog No. A13362
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    JAK2/HDAC dual inhibitor
    JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. 了解更多
  31. Sodium phenylbutyrate

    Catalog No. A16714
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    HDAC/ER stress inhibitor
    Sodium phenylbutyrate is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. 了解更多
  32. Tubastatin A

    Catalog No. A16770
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    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). 了解更多
  33. CG-200745

    Catalog No. A20939
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    HDAC inhibitor
    CG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. 了解更多
  34. Givinostat

    Catalog No. A21126
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    HDAC inhibitor
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. 了解更多
  35. HDAC-IN-7

    Catalog No. A21252
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    HDAC1/2/3/10 inhibitor
    HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. 了解更多
  36. Givinostat hydrochloride

    Catalog No. A21487
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    HDAC inhibitor
    Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. 了解更多
  37. Nanatinostat

    Catalog No. A21625
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    HDAC inhibitor
    Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. 了解更多
  38. Belinostat

    Catalog No. A21772
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    HDAC inhibitor
    Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. 了解更多
  39. HDAC-IN-5

    Catalog No. A20972
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    HDAC inhibitor
    HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. 了解更多
  40. Domatinostat tosylate

    Catalog No. A20986
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    HDAC1 inhibitor
    Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 了解更多
  41. CUDC-101

    Catalog No. A10246
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    HDAC 抑制剂
    CUDC-101是一种抑制多种靶标的新型化合物,旨在抑制HDAC,EGFR和Her2。 了解更多
  42. ITF2357 (Givinostat)

    Catalog No. A10488
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    HDAC 抑制剂
    ITF2357 (Givinostat)是一种HDACS抑制剂,具有潜在的抗炎、抗血管生成和抗肿瘤活性。 了解更多
  43. Droxinostat

    Catalog No. A10337
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    HDAC 抑制剂
    Droxinostat是HDAC3,HDAC6和HDAC8的选择性抑制剂,显示出可比较的HDAC6和HDAC8抑制作用,IC50分别为2.47和1.46μmol/ L。 了解更多
  44. PCI-24781 (Abexinostat)

    Catalog No. A10700
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    HDAC 抑制剂
    PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。 了解更多
  45. Tubastatin A HCl

    Catalog No. A11042
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    HDAC6 抑制剂
    Tubastatin A HCl是一种有效的选择性HDAC6抑制剂,在无细胞试验中IC50为15 nM。它对除HDAC8(57倍)以外的所有其他同工酶(1000倍)具有选择性。 了解更多
  46. Pyroxamide (NSC 696085)

    Catalog No. A10764
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    HDAC 抑制剂
    Pyroxamide (NSC 696085)是亲和纯化的HDAC1的有效抑制剂,可导致乙酰化核心组蛋白在用该试剂培养的MEL细胞中积累。 了解更多
  47. PCI-34051

    Catalog No. A11152
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    HDAC 抑制剂
    PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8(HDAC8)抑制剂,其选择性是其他HDAC亚型的200倍以上。 了解更多
  48. Parthenolide ((-)-Parthenolide)

    Catalog No. A10698
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    Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。 了解更多
  49. Tubacin

    Catalog No. A10954
    HDAC6 抑制剂
    Tubacin (tubulin acetylation inducer)是一种高效且选择性强,可逆,可透过细胞的HDAC6抑制剂,IC50为4 nM。 了解更多
  50. LAQ824 (NVP-LAQ824, Dacinostat)

    Catalog No. A10516
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    HDAC 抑制剂
    LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂,具有显著的抗多发性骨髓瘤活性。 了解更多

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