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Olaparib (AZD2281)
Catalog No. A10111 PARP 抑制剂Olaparib (AZD2281)是聚ADP核糖聚合酶（PARP）的抑制剂，该酶是一种与DNA修复有关的酶。 了解更多 -
AG-014699 (Rucaparib)
Catalog No. A10045 PARP 抑制剂AG-014699 (Rucaparib)是一种PARP抑制剂，可抑制聚（ADP-核糖）聚合酶（PARP，后者是DNA修复中的关键酶。 无细胞试验中作用于PARP1的Ki为1.4 nM，对其余8个PARP位点也有结合亲和力。 了解更多 -
3-Aminobenzamide
Catalog No. A10475 PARP 抑制剂3-Aminobenzamide是一种新型PARP抑制剂，已知它通过抑制DNA损伤的修复使细胞在体外对辐射敏感。 了解更多 -
MK-4827 (Niraparib)
Catalog No. A11026 PARP 抑制剂MK-4827 (Niraparib)是一种新型有效的口服生物可利用的PARP-1和PARP-2抑制剂。 了解更多 -
PJ 34 hydrochloride
Catalog No. A12665 PARP 抑制剂PJ 34 hydrochloride是聚（ADP-核糖）聚合酶（PARP）（EC50 = 20 nM）的有效抑制剂。 了解更多 -
AZD-2461
Catalog No. A12393 -
ME0328
Catalog No. A14309 -
Benzamide
Catalog No. A14371 -
BMN-673 8R,9S
Catalog No. A15024 -
PJ34
Catalog No. A15215 -
Pamiparib
Catalog No. A17073 -
Rucaparib (Camsylate)
Catalog No. A18013 PARP 抑制剂Rucaparib Camsylate is an inhibitor of PARP with a Ki of 1.4 nM for PARP1, and also shows binding affinity to eight other PARP domains. 了解更多 -
PARP14 inhibitor H10
Catalog No. A18616 PARP14 抑制剂PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (??24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. 了解更多 -
Niraparib tosylate
Catalog No. A16618 PARP1/PARP2 inhibitorNiraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. 了解更多 -
Niraparib hydrochloride
Catalog No. A18018 PARP1 and PARP2 inhibitorNiraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多 -
Niraparib R-enantiomer
Catalog No. A21880 PARP1 inhibitorNiraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. 了解更多 -
Veliparib dihydrochloride
Catalog No. A21356 PARP inhibitorVeliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. 了解更多 -
INCB018424 (Ruxolitinib)
Catalog No. A11041 JAK1/2 抑制剂INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂，对JAK1，JAK2和JAK3的IC50分别为2.7、4.5和332 nM。 了解更多 -
AZD1480
Catalog No. A10110 -
LY2784544 (Gandotinib)
Catalog No. A10546 -
CP-690550 (Tofacitinib citrate)
Catalog No. A10241 JAK3 抑制剂CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶（JAK）酶抑制剂。 了解更多 -
Cyt387 (Momelotinib)
Catalog No. A10263 JAK 抑制剂Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂，可作为ATP竞争者，IC50值分别为11和18 nM。 了解更多 -
TG-101348 (Fedratinib, SAR302503)
Catalog No. A11082 JAK2/FLT3 抑制剂TG-101348 (Fedratinib,SAR302503)是Janus相关激酶2的口服生物利用型，ATP竞争性和选择性抑制剂，在无细胞试验中IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,具有潜在的抗肿瘤活性。 了解更多 -
NVP-BSK805
Catalog No. A11193 JAK 抑制剂NVP-BSK805是喹喔啉JAK2抑制剂对红细胞增多症的有效和选择性抑制，喹喔啉JAK2抑制剂可有效抑制小鼠和大鼠中重组人促红细胞生成素诱导的红细胞增多症和髓外红细胞生成。IC50为0.5 nM，比作用于JAK1， JAK3和TYK2选择性高20倍以上。 了解更多 -
Baricitinib (LY3009104)
Catalog No. A11329 JAK 抑制剂Baricitinib，也称为INCB028050或LY3009104，是一种选择性口服可生物利用的JAK1/JAK2抑制剂，对JAK1（5.9 nM）和JAK2（5.7 nM）具有纳摩尔浓度。 了解更多 -
Pacritinib (SB1518)
Catalog No. A12694 JAK2/FLT3 抑制剂Pacritinib (SB1518)是Janus激酶2（JAK2）和JAK2突变体JAK2V617F的口服生物利用抑制剂，无细胞试验中IC50分别为23和22 nM，具有潜在的抗肿瘤活性。Pacritinib与JAK2竞争ATP结合，这可能导致抑制JAK2活化，抑制JAK-STAT信号传导途径以及半胱天冬酶依赖性凋亡。 了解更多
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