你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
Products On Sale

Products On Sale

Quick View
Marbofloxacin

Catalog No. A10557
Quick View

添加到收藏
Topoisomerase 抑制剂

Marbofloxacin是有效的第三代氟喹诺酮类抗生素，通过抑制细菌DNA复制起作用。了解更多

Bulk Inquiry Free Sample
Quick View
Raltitrexed (Tomudex)

Catalog No. A10776
Quick View

添加到收藏
DNA/RNA Synthesis 抑制剂

Raltitrexed (Tomudex)是胸苷酸合酶的抑制剂，也是使用中最强的抗代谢物之一。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
Quick View
Topotecan HCl (Hycamtin)

Catalog No. A10939
Quick View

添加到收藏
DNA topoisomerase I 抑制剂

Topotecan HCl (Hycamtin)是一种化学治疗剂，是拓扑异构酶抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Vatalanib (PTK787) 2HCl

Catalog No. A10967
Quick View

添加到收藏
VEGFR 抑制剂

Vatalanib (PTK787) 2HCl是一种小分子蛋白激酶抑制剂，可抑制抑制所有已知VEGF受体以及血小板衍生的生长因子受体β和c-kit的血管生成，但对VEGFR-2的选择性最高。了解更多

Bulk Inquiry Free Sample
Quick View
Abiraterone (CB-7598)

Catalog No. A10020
Quick View

添加到收藏
CYP17 抑制剂

Abiraterone (CB-7598)是一种有效CYP17抑制剂，20裂合酶（CYP17A1）。了解更多

Bulk Inquiry Free Sample
Quick View
Abiraterone Acetate (CB7630)

Catalog No. A11058
Quick View

添加到收藏
CYP17 抑制剂

Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Docetaxel (Taxotere)

Catalog No. A10326
Quick View

添加到收藏
Microtubule Associated 抑制剂

Docetaxel (Taxotere)多西他赛一种taxol类似物，是一种microtubules解聚抑制剂，通过结合于稳定的微管发挥作用。了解更多

Bulk Inquiry Free Sample
Quick View
Paclitaxel (Taxol)

Catalog No. A10689
Quick View

添加到收藏
Microtubule Associated 抑制剂

Paclitaxel (Taxol)是一种有丝分裂抑制剂，可稳定微管，从而干扰细胞分裂过程中微管的正常分解，在人内皮细胞中IC50为0.1pM。了解更多

Product Citations (5)

Bulk Inquiry Free Sample
- Yu Pan, .et al. The nature of the modification at position 37 of tRNAPhe correlates with acquired taxol resistance, Nucleic Acids Res, 2021, Jan 11;49(1):38-52 PMID: 33290562
- Li-Li Li, .et al. Resonance energy transfer sensitises and monitors in situ switching of LOV2-based optogenetic actuators, Nat Commun, 2020, Oct 9;11(1):5107 PMID: 33037199
- Baglo Y, .et al. Harnessing the Potential Synergistic Interplay Between Photosensitizer Dark Toxicity and Chemotherapy, Photochem Photobiol, 2019, Dec 19 PMID: 31856423
- Owiti AO, .et al. PSMA Antibody-Conjugated Pentablock Copolymer Nanomicellar Formulation for Targeted Delivery to Prostate Cancer, AAPS PharmSciTech, 2018, Nov;19(8):3534-3549 PMID: 30151731
- Owiti AO, .et al. Strategic Pentablock Copolymer Nanomicellar Formulation for Paclitaxel Delivery System, AAPS PharmSciTech, 2018, Oct;19(7):3110-3122 PMID: 30112614
Quick View
Vincristine sulfate

Catalog No. A10973
Quick View

添加到收藏
Tubulin 抑制剂

Vincristine sulfate是一种有丝分裂抑制剂。了解更多

Bulk Inquiry
Quick View
Epothilone B (EPO906)

Catalog No. A10360
Quick View

添加到收藏
Microtubule Associated 抑制剂

Epothilone B (EPO906)是一种紫杉醇样microtubule稳定剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Yicheng Zhu, .et al. Combinatrial treatment of anti-High Mobility Group Box-1 monoclonal antibody and epothilone B improves functional recovery after spinal cord contusion injury, Neurosci Res, 2021, Apr 17 PMID: 33864880
Quick View
Dasatinib (BMS-354825)

Catalog No. A10290
Quick View

添加到收藏
Abl-Src 抑制剂

Dasatinib (BMS-354825)是一种口服多BCR/ABL和Src家族酪氨酸激酶抑制剂。Dasatinib (BMS-354825)的主要靶标是BCR/ABL，Src，c-Kit，ephrin受体和其他几种酪氨酸激酶，但不是erbB激酶，例如EGFR或Her2。了解更多

Product Citations (10)

Bulk Inquiry Free Sample
- Chihiro Motozono, .et al. The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition, Nat Commun, 2022, Sep 21;13(1):5440 PMID: 36130929
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- David E J Klawon, .et al. Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration, J Exp Med, 2021, Jun 7;218(6) PMID: 33914024
- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
- Sano T, .et al. Gliding Basal Cell Migration of the Urothelium during Wound Healing, Am J Pathol, 2018, Nov;188(11):2564-2573 PMID: 30121259
- Ines Peschel, .et al. FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia, Haematologica, 2017, Aug; 102(8): 1378-1389 PMID: 28522571
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
- John D. Leonard, .et al. Identification of natural regulatory T cell epitopes reveals convergence on a dominant autoantigen, Immunity, 2017, Jul 18; 47(1): 107-117.e8 PMID: 28709804
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Quick View
BMS-754807

Catalog No. A11059
Quick View

添加到收藏
IGF-1R 抑制剂

BMS-754807是一种有效的，口服活性生长因子1受体/胰岛素受体家族靶向的激酶抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Quick View
CX-4945 (Silmitasertib)

Catalog No. A11060
Quick View

添加到收藏
CK2 抑制剂

CX-4945 (Silmitasertib)是有效的，选择性CK2(casein kinase 2)抑制剂，可抑制人脐静脉内皮细胞迁移，管形成，并阻止癌细胞中CK2依赖性缺氧诱导的因子1α（HIF-1α）转录。了解更多

Product Citations (13)

Bulk Inquiry Free Sample
- Xixi Zhao, .et al. Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function, Cancer Res, 2022, Jun 6;82(11):2185-2195 PMID: 35385574
- Janeen H. Trembley, .et al. CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(-) HNSCC Cell Lines, Biomedicines, 2021, May; 9(5): 571 PMID: 34070147
- Tianzhi Huang, .et al. PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells, Mol Cell, 2021, Mar 18;81(6):1276-1291 PMID: 33539787
- M Afzal, .et al. Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer, Molecular and Cellular Biochemistry, 2020, 470, pages131-143
- Zaman MS, .et al. Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells, Biometals, 2019, Oct 3 PMID: 31583500
- Fukumoto Y, .et al. Human Rad17?C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex, Biochem Biophys Res Commun, 2019, Sep 17;517(2):310-316 PMID: 31353086
- Fukumoto Y, .et al. Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17, Biochem Biophys Res Commun, 2018, Oct 2;504(2):380-386 PMID: 29902452
- ST Ribeiro, .et al. Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling, Leukemia, 2017, Jul; 31(7): 1603-1610 PMID: 27899804
- Valentina Gandin, .et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly, Nat Commun, 2016, 7: 11127 PMID: 27040916
- Ampofo E, .et al. Protein Kinase CK2 Regulates Leukocyte-Endothelial Cell Interactions during Ischemia and Reperfusion in Striated Skin Muscle, Eur Surg Res, 2016, 57(1-2):111-24 PMID: 27287005
- Emmanuel Ampofo, .et al. Role of protein kinase CK2 in the dynamic interaction of platelets, leukocytes and endothelial cells during thrombus formation., Thromb Res., 2015, Nov;136(5):996-1006 PMID: 26381437
- Emmanuel Ampofo, .et al. Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-α-induced leukocyte-endothelial cell interaction., Biochim Biophys Acta., 2015, Oct;1852(10 Pt A):2123-36 PMID: 26189586
- A. Margarida Gomes, .et al. Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels, Haematologica, 2014, 99(6): 1062-1068 PMID: 24561792
Quick View
ENMD-2076

Catalog No. A10352
Quick View

添加到收藏
Aurora A / FLT3 抑制剂

ENMD-2076具有针对Aurora A和Flt3的选择性活性，IC50为14 nM和1.86 nM，对Aurora A的选择性是Aurora B的25倍，对VEGFR2/KDR和VEGFR3，FGFR1和FGFR2和PDGFRα的作用较小。阶段2。了解更多

Bulk Inquiry Free Sample
Quick View
KW-2449

Catalog No. A10508
Quick View

添加到收藏
FLT3/FGFR/Bcr-Abl/Aurora 抑制剂

KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Curcumol

Catalog No. A10247
Quick View

添加到收藏
JAK2 抑制剂

Curcumol是常见的传统中药，具有抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
Taxifolin

Catalog No. A10893
Quick View

添加到收藏
VEGFR-2 抑制剂

Taxifolin以很大的结合能值结合在VEGFR-2激酶的ATP结合位点上，并起I型竞争性抑制剂的作用。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Keji Yu, .et al. A role for ascorbate conjugates of (+)-catechin in proanthocyanidin polymerization, Nat Commun, 2022, Jun 14;13(1):3425 PMID: 35701431
- Shinji Kondo, .et al. Antidiabetic Effect of Taxifolin in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Hyperglycemia and Hyperuricemia, Curr Issues Mol Biol, 2021, Sep 26;43(3):1293-1306 PMID: 34698101
- Shin-ichi Adachi, .et al. Anti-hyperuricemic effect of taxifolin in cultured hepatocytes and model mice, Cytotechnology, 2017, Apr; 69(2): 329-336 PMID: 28101741
Quick View
GSK461364

Catalog No. A10442
Quick View

添加到收藏
PLK 抑制剂

GSK461364 是polo样激酶1 (Plk1)的ATP竞争性抑制剂。了解更多

Bulk Inquiry
Quick View
SB 216763

Catalog No. A10825
Quick View

添加到收藏
GSK-3 抑制剂

SB 216763是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为34 nM（与GSK3β相似的效力）。了解更多

Bulk Inquiry Free Sample
Quick View
SB 415286

Catalog No. A11061
Quick View

添加到收藏
GSK-3 抑制剂

SB 415286是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为78 nM（与GSK3β相似的效价），Ki值为31 nM。了解更多

Bulk Inquiry Free Sample
Quick View
CX-5461

Catalog No. A11065
Quick View

添加到收藏
DNA/RNA Synthesis 抑制剂

CX-5461是RNA聚合酶I（Pol I）的一流的非遗传毒性小分子靶向抑制剂，可激活p53途径而不会引起DNA损伤。了解更多

Product Citations (10)

Bulk Inquiry Free Sample
- Taro Mannena, .et al. Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines, Mol Biol Cell, 2021, 32:ar33, 1?C11 PMID: 34495685
- Shuichiro Okamoto, .et al. The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells, Biosci Biotechnol Biochem, 2020, Aug 15;1-8 PMID: 32799625
- Ahmed Abdullah Ahmed, .et al. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells, Sci Rep, 2020, 10: 12192 PMID: 32699225
- Abed Saady, .et al. Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells, Dyes Pigm, 2020, 174: 107986
- Jackobel AJ, .et al. DNA binding preferences of S. cerevisiae RNA polymerase I Core Factor reveal a preference for the GC-minor groove and a conserved binding mechanism, Biochim Biophys Acta Gene Regul Mech, 2019, Aug 2:194408 PMID: 31382053
- Hiroaki Suzuki, .et al. The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesi, Cell Death Dis, 2018, Oct; 9(10): 975 PMID: 30250194
- Anastasia Gelgor, .et al. Nucleolar stress enhances lytic reactivation of the Kaposi??s sarcoma-associated herpesvirus, Oncotarget, 2018, Mar 2; 9(17): 13822-13833 PMID: 29568397
- Wang ZF, .et al. The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules, Cell Chem Biol, 2018, Nov 29. pii: S2451-9456(18)30378-7 PMID: 30503283
- Yuko Fujiwara, .et al. A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network, EBioMedicine, 2018, Jul; 33: 33-48 PMID: 30049386
- Maïmouna Coura Kone, .et al. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development, Biol Reprod, 2016, Apr;94(4):95, 1-12 PMID: 26984997
Quick View
TAK-901

Catalog No. A11067
Quick View

添加到收藏
Aurora Kinase A/B 抑制剂

TAK-901是一种新型Aurora A/B抑制剂，IC50为21 nM/15 nM。它不是细胞JAK2，c-Src或Abl的有效抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
S/GSK1349572 (Dolutegravir)

Catalog No. A11068
Quick View

添加到收藏
HIV integrase 抑制剂

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
Quick View
MK-0752

Catalog No. A11194
Quick View

添加到收藏
Gamma-secretase 抑制剂

MK-0752抑制Notch信号通路，这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。了解更多

Bulk Inquiry Free Sample
Quick View
PF-562271

Catalog No. A11192
Quick View

添加到收藏
FAK 抑制剂

PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，作用于FAK比作用于Pyk2选择性高10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Jiping Yue, .et al. In vivo epidermal migration requires focal adhesion targeting of ACF7, Nat Commun, 2016, 7: 11692 PMID: 27216888
Quick View
GSK1904529A

Catalog No. A10440
Quick View

添加到收藏
IGF-1R 抑制剂

GSK1904529A分别用27和25 nmol/L的IC(50)s选择性抑制IGF-IR和IR。了解更多

Bulk Inquiry Free Sample
Quick View
AZD4547

Catalog No. A11075
Quick View

添加到收藏
FGFR 抑制剂

AZD4547是一种有效，选择性和口服活性的pan-FGFR抑制剂，对于FGFR1、2、3和4的IC50分别为0.2、2.5、1.8和165 nM。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Ryuma Tokunaga, .et al. Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma, Oncotarget, 2016, Apr 12; 7(15): 19748-19761 PMID: 26933914
- Mitsuko Kawano, .et al. FGF18 signaling in the hair cycle resting phase determines radioresistance of hair follicles by arresting hair cycling, Adv Radiat Oncol, 2016, Jul-Sep; 1(3): 170-181 PMID: 28740887
Quick View
ZM 336372

Catalog No. A11077
Quick View

添加到收藏
C-Raf 抑制剂

ZM 336372是有效的ATP Raf-1体外竞争性抑制剂 (IC50 = 70 nM)。了解更多

Bulk Inquiry Free Sample
Quick View
PKI-587 ( Gedatolisib )

Catalog No. A11079
Quick View

添加到收藏
PI3K/mTOR 抑制剂

PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。了解更多

Bulk Inquiry Free Sample
Quick View
TG-101348 (Fedratinib, SAR302503)

Catalog No. A11082
Quick View

添加到收藏
JAK2/FLT3 抑制剂

TG-101348 (Fedratinib,SAR302503)是Janus相关激酶2的口服生物利用型，ATP竞争性和选择性抑制剂，在无细胞试验中IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,具有潜在的抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
GW788388

Catalog No. A11083
Quick View

添加到收藏
TGF-beta/Smad 抑制剂

GW788388是有效的，口服活性的，选择性的转化生长因子β受体I（TGF-βR1）（激活素受体样激酶5，ALK5）抑制剂,无细胞试验中IC50为18 nM，也抑制TGF-βII型受体和activin II型受体活性，但不抑制BMP II型受体。了解更多

Bulk Inquiry Free Sample
Quick View
Telaprevir (VX-950)

Catalog No. A10902
Quick View

添加到收藏
HCV NS3-4A protease 抑制剂

Telaprevir (VX-950)被称为蛋白酶抑制剂，可抑制丙型肝炎病毒NS3.4A丝氨酸蛋白酶。了解更多

Product Citations (9)

Bulk Inquiry Free Sample
- Mahim Khan, .et al. Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease, BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
- Adita Ayu Permanasari, .et al. An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs, BMC Complement Med Ther, 2021, Oct 12;21(1):260 PMID: 34641875
- Che C Colpitts, .et al. Hepatitis C virus exploits cyclophilin A to evade PKR, eLife, 2020, 9: e52237 PMID: 32539931
- TS Wahyuni, .et al. Enhancement of Anti-Hepatitis C Virus Activity by the Combination of Chalepin From Ruta Angustifolia and Current Antiviral Drugs, Southeast Asian J Trop Med public health, 2020, 51(1)
- Stefan Bittmann, .et al. TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat, J Regen Biol Med, 2020, 2(2):1-3
- Wahyuni TS, .et al. Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor, J Basic Clin Physiol Pharmacol, 2019, Dec 14 PMID: 31837259
- Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
- Apriyanto DR, .et al. Anti-Hepatitis C Virus Activity of a Crude Extract from Longan (Dimocarpus longan Lour.) Leaves, Jpn J Infect Dis, 2016, May 20;69(3):213-20 PMID: 26255732
- Mizuki Yamamoto, .et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352
Quick View
BIBR-1048 (Dabigatran etexilate)

Catalog No. A10139
Quick View

添加到收藏
Thrombin 抑制剂

BIBR-1048 (Dabigatran etexilate)是dabigatran的前体药物，dabigatran是一种有效的、非肽类小分子化合物，可特异地、可逆性地抑制游离的和结合了血凝块的凝血酶。了解更多

Bulk Inquiry Free Sample
Quick View
Anacetrapib (MK-0859)

Catalog No. A11084
Quick View

添加到收藏
CETP 抑制剂

Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。了解更多

Bulk Inquiry Free Sample
Quick View
LY315920 (Varespladib)

Catalog No. A10548
Quick View

添加到收藏
HnsPLA 抑制剂

LY315920 (Varespladib)是分泌型磷脂酶A2 (sPLA2)的IIa、V和X亚型的抑制剂。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Yap WH, .et al. Differential effects of sPLA2-GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells, Mol Cell Biochem, 2018, Oct;447(1-2):93-101 PMID: 29374817
- Yamato Okita, .et al. Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes, Infect Immun, 2016, Feb; 84(2): 573-579 PMID: 26644377
Quick View
CHIR-98014

Catalog No. A11085
Quick View

添加到收藏
GSK-3 抑制剂

CHIR-98014是一种非常有效的，选择性的，细胞可渗透的GSK-3抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
ARQ 197 (Tivantinib)

Catalog No. A11087
Quick View

添加到收藏
c-Met 抑制剂

ARQ-197是c-Met受体酪氨酸激酶的选择性抑制剂, 在无细胞试验中Ki为0.355 μM，对Ron几乎没有作用活性，对EGFR， InsR， PDGFRα和FGFR1/4没有抑制作用。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Wang L, .et al. Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function, J Am Chem Soc, 2019, Aug 14;141(32):12673-12681 PMID: 31381313
- Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
Quick View
Pyroxamide (NSC 696085)

Catalog No. A10764
Quick View

添加到收藏
HDAC 抑制剂

Pyroxamide (NSC 696085)是亲和纯化的HDAC1的有效抑制剂，可导致乙酰化核心组蛋白在用该试剂培养的MEL细胞中积累。了解更多

Bulk Inquiry Free Sample
Quick View
Nitisinone

Catalog No. A11093
Quick View

添加到收藏
HPPD 抑制剂

Nitrisinone是一种竞争性抑制剂，可逆地抑制4-羟基苯基丙酮酸氧化酶（双加氧酶）。了解更多

Bulk Inquiry Free Sample
Quick View
DAPT (GSI-IX)

Catalog No. A10288
Quick View

添加到收藏
Gamma secretase 抑制剂

DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
- Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
Quick View
Dapagliflozin (BMS512148)

Catalog No. A10285
Quick View

添加到收藏
SGLT2 抑制剂

Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白（SGLT2）的亚型2，后者负责肾脏中至少90％的葡萄糖重吸收。了解更多

Product Citations (5)

Bulk Inquiry Free Sample
- David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
- Neil Tanday, .et al. Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta- to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance, Biochem Pharmacol, 2020, Jul;177:114009 PMID: 32360307
- Subramaniam M, .et al. Comparison of Intestinal Glucose Flux and Electrogenic Current Demonstrates Two Absorptive Pathways in Pig and One in Nile Tilapia and Rainbow Trout, Am J Physiol Regul Integr Comp Physiol, 2019, Nov 20 PMID: 31746628
- Marina Subramaniam, .et al. Sigmoidal kinetics define porcine intestinal segregation of electrogenic monosaccharide transport systems as having multiple transporter population involvement, Physiol Rep, 2019, May; 7(9): e14090 PMID: 31062524
- Angelopoulou A, .et al. Magnetic Nanoparticles for the Delivery of Dapagliflozin to Hypoxic Tumors: Physicochemical Characterization and Cell Studies, AAPS PharmSciTech, 2018, Feb;19(2):621-633 PMID: 8924948
Quick View
NU-7441 (KU-57788)

Catalog No. A11098
Quick View

添加到收藏
DNA-PK 抑制剂

NU-7441 (KU-57788)是一种有效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂。对于DNA-PK，mTOR，PI 3-K，ATM和ATR，IC50值分别为14、1700、5000，> 100000和> 100000 nM。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Shahar Biechonski, .et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation, Sci Rep, 2018, Apr 17 PMID: 29666389
- Ihara M, .et al. Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines, J Radiat Res, 2018, Nov 23 PMID: 30476230
- Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201
- Masaaki Yanai, .et al. DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair, Yonago Acta Med, 2017, Mar; 60(1): 9-15 PMID: 28331416
Quick View
AS-252424

Catalog No. A11099
Quick View

添加到收藏
PI3K 抑制剂

AS-252424是有效的PI3K抑制剂，对γ亚型具有选择性。它抑制人重组PI3Kγ，α，β和δ，IC50值分别为30、940、20,000和20,000 nM。了解更多

Bulk Inquiry Free Sample
Quick View
Canagliflozin

Catalog No. A11100
Quick View

添加到收藏
SGLT2 抑制剂

canagliflozin是2型亚钠葡萄糖转运蛋白（SGLT2）的抑制剂,作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
- Angelopoulou A, .et al. Canagliflozin-loaded magnetic nanoparticles as potential treatment of hypoxic tumors in combination with radiotherapy, Nanomedicine, 2018, Oct;13(19):2435-2454 PMID: 30311542
Quick View
AZ-960

Catalog No. A10104
Quick View

添加到收藏
JAK2抑制剂

AZ-960是一种有效的，选择性的和ATP竞争性的JAK2抑制剂，在体外抑制JAK2激酶的Ki为0.45 nM，并诱导成年T细胞白血病（ATL）细胞的生长停滞和凋亡了解更多

Bulk Inquiry Free Sample
Quick View
Methotrexate (Abitrexate)

Catalog No. A10021
Quick View

添加到收藏
DHFR 抑制剂

Methotrexate (Abitrexate)是一种抑制胸苷酸合成酶和从头嘌呤合成的细胞毒剂。了解更多

Bulk Inquiry Free Sample
Quick View
Saxagliptin (BMS-477118)

Catalog No. A11109
Quick View

添加到收藏
DPP-4 抑制剂

Saxagliptin (BMS-477118)是一种新型二肽基肽酶4（DPP-4）抑制剂，IC50为50 nM。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- OHE El-Shoubashy, .et al. Comparative study of HPLC-DAD and HPTLC for the simultaneous determination of a new multitarget antidiabetic ternary mixture in combined tablets, JPC, 2020, 33, 59-70
- Sato T, .et al. DPP8 is a novel therapeutic target for multiple myeloma, Sci Rep, 2019, Dec 2;9(1):18094 PMID: 31792328
- Chintan N. Koyani, .et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes, Front Physiol, 2018, 9: 1622 PMID: 30487758
- Koyani CN, .et al. Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure, Biochem Pharmacol, 2016, Dec 1;145:64-80 PMID: 28859968
Quick View
Rasagiline

Catalog No. A11111
Quick View

添加到收藏
MAO B 抑制剂

Rasagiline是MAO-B（单胺氧化酶-B）的选择性不可逆抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Avasimibe (CI-1011)

Catalog No. A10102
Quick View

添加到收藏
CYP17 抑制剂

Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂，IC50分别为2.9 μM， 13.9 μM和26.5 μM。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Yuyan Zhu, .et al. Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake, Metabolism, 2021, Oct;123:154861 PMID: 34371065
Quick View
TOK-001 (Galeterone)

Catalog No. A11138
Quick View

添加到收藏
CYP17 抑制剂

TOK-001 (Galeterone)既是雄激素受体拮抗剂又是CYP17A1抑制剂。了解更多

Bulk Inquiry Free Sample

联系我们

Not your Region? View all Distributors

溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.