购物车 0 ￥ 0.00
微信关注
申请试用装
  • 主页 /
  • 搜索结果：“akt”

“akt”的搜索结果

50 个项目

每页

设置升序顺序
  1. KU-55933
    Quick View

    KU-55933

    Catalog No. A10506
    Quick View
    ATM 抑制剂
    KU-55933是ATM抑制剂，通过抑制细胞增殖，并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。 了解更多
  2. BX-795
    Quick View

    BX-795

    Catalog No. A11148
    Quick View
    PDK-1 抑制剂
    BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。 了解更多
  3. AT13148
    Quick View

    AT13148

    Catalog No. A12464
    Quick View
    multi-AGC kinase 抑制剂
    AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。 了解更多
  4. LY3023414
    Quick View

    LY3023414

    Catalog No. A16126
    Quick View
    PI3K/mTOR Dual 抑制剂
    LY3023414是从专利WO/2012097039A1（化合物实施例1）中提取的I类PI3K同种型，mTOR和DNA-PK的口服ATP竞争性抑制剂，对Akt1（pT308）的IC50为64.9 nM，42.1 nM，10.6 nM和19.1 nM。），Akt1（pS473），P70S6（pT389），S6RP（pS240/242）。 了解更多
  5. Tenalisib (RP6530)
    Quick View

    Tenalisib (RP6530)

    Catalog No. A16799
    Quick View
    dual PI3Kδ/γ 抑制剂
    Tenalisib (RP6530)是一种有效且选择性的双重PI3Kδ/PI3Kγ抑制剂，能抑制B细胞淋巴瘤细胞系的生长，同时降低下游生物标记物pAKT。 了解更多
  6. mTOR inhibitor-2
    Quick View

    mTOR inhibitor-2

    Catalog No. A13035
    Quick View
    mTOR inhibitor
    mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates. 了解更多
  7. 3CAI
    Quick View

    3CAI

    Catalog No. A20924
    Quick View
    AKT1/AKT2 inhibitor
    3CAI is a potent and specific AKT1 and AKT2 inhibitor. 了解更多
  8. MK-2206 2HCl
    Quick View

    MK-2206 2HCl

    Catalog No. A10003
    Quick View
    AKT 抑制剂
    MK-2206 2HCl是Akt1/2/3的高选择性抑制剂，IC50分别为8 nM/12 nM/65 nM。 了解更多
  9. Perifosine (NSC-639966)
    Quick View

    Perifosine (NSC-639966)

    Catalog No. A10709
    Quick View
    Akt 抑制剂
    Perifosine (也为KRX-0401) 充当Akt抑制剂和PI3K抑制剂。 了解更多
  10. GSK690693
    Quick View

    GSK690693

    Catalog No. A11030
    Quick View
    AKT 抑制剂
    GSK690693是一种新型的ATP竞争性低纳摩尔泛Akt激酶抑制剂（IC50值分别为Akt1、2和3的2、13和9 nM）。 了解更多
  11. AT7867
    Quick View

    AT7867

    Catalog No. A10094
    Quick View
    AKT 抑制剂
    AT7867是AKT和下游激酶p70 S6激酶（p70S6K）以及蛋白激酶A的新型有效抑制剂。 了解更多
  12. CCT128930
    Quick View

    CCT128930

    Catalog No. A11031
    Quick View
    AKT 抑制剂
    CCT128930是一种具有ATP竞争性的AKT抑制剂，是一种有效的高级吡咯并嘧啶铅化合物，相对于PKA表现出对AKT的选择性，可通过靶向单个氨基酸差异实现。 了解更多
  13. PHT-427
    Quick View

    PHT-427

    Catalog No. A11032
    Quick View
    AKT 抑制剂
    PHT-427是一种新型的Akt/磷脂酰肌醇依赖性蛋白激酶1 pleckstrin同源域抑制剂。 了解更多
  14. Triciribine phosphate (NSC-280594)
    Quick View

    Triciribine phosphate (NSC-280594)

    Catalog No. A11033
    Quick View
    AKT 抑制剂
    Triciribine phosphate是一种DNA synthesis抑制剂，也抑制PC3细胞系中的Akt和CEM-SS，H9，H9IIIB，U1细胞中的HIV-1，IC50分别为130 nM和20 nM；对PI3K/PDK1没有抑制作用；作用于缺乏腺苷激酶的细胞，活性降低5000 了解更多
  15. A-674563
    Quick View

    A-674563

    Catalog No. A11034
    Quick View
    Akt 抑制剂
    A-674563是一种B/Akt抑制剂，IC50为14 nM，并且还显示出对PKA和CDK2的抑制活性，IC50分别为16和46 nM。 了解更多
  16. A-443654
    Quick View

    A-443654

    Catalog No. A11287
    Quick View
    Akt 抑制剂
    A-443654是Ki值为160 pM的特异Akt抑制剂，可干扰有丝分裂进程和双极纺锤体形成。 了解更多
  17. AZD5363
    Quick View

    AZD5363

    Catalog No. A11759
    Quick View
    AKT 抑制剂
    AZD5363是有效的AKT抑制剂，在体内具有药效学活性，有潜力作为单一疗法或联合用药来治疗一系列实体瘤和血液肿瘤。 了解更多
  18. GDC-0068 (Ipatasertib, RG-7440)
    Quick View

    GDC-0068 (Ipatasertib, RG-7440)

    Catalog No. A11246
    Quick View
    Akt 抑制剂
    GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3的IC50值分别为5、18和8 nM。 了解更多
  19. KP372-1
    Quick View

    KP372-1

    Catalog No. A12877
    Quick View
    Akt 抑制剂
    KP372-1是合成的小分子AKT抑制剂。 了解更多
  20. Triciribine
    Quick View

    Triciribine

    Catalog No. A13210
    Quick View
    AKT 抑制剂
    Triciribine，也称为API-2，可抑制Akt的磷酸化水平和激酶活性。 了解更多
  21. TIC10 isomer
    Quick View

    TIC10 isomer

    Catalog No. A12720
    Quick View
    AKT 抑制剂?
    TIC10通过Foxo3a使Akt和ERK失活，从而诱导TRAIL，具有优越的药物特性：跨血脑屏障传递，优异的稳定性和改善的药代动力学。 了解更多
  22. Miltefosine
    Quick View

    Miltefosine

    Catalog No. A14138
    Quick View
    PI3K/Akt 抑制剂
    Miltefosine在癌细胞系A431和HeLa中抑制PI3K/Akt活性，ED50为17.2μM和8.1μM。 了解更多
  23. SR-13668
    Quick View

    SR-13668

    Catalog No. A13554
    Quick View
    AKT 抑制剂?
    SR-136683是一种口服制剂，其中含有血管内皮生长因子受体（VEGFR）和血小板衍生生长因子受体（PDGFR）的小分子受体酪氨酸激酶抑制剂，具有潜在的抗肿瘤活性。 了解更多
  24. Afuresertib HCl
    Quick View

    Afuresertib HCl

    Catalog No. A13030
    Quick View
    AKT 抑制剂?
    Afuresertib HCl，也称为GSK2110183，是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt（蛋白激酶B）的生物利用抑制剂。它结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关，PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。 了解更多
  25. AT7867 2HCl
    Quick View

    AT7867 2HCl

    Catalog No. A15006
    Quick View
    Akt 抑制剂
    AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，在AGC激酶家族之外几乎没有活性。 了解更多
  26. SC79
    Quick View

    SC79

    Catalog No. A15541
    Quick View
    Akt phosphorylation activator
    SC79是AKT激活剂。SC79绑定到模仿PtdIns（3,4,5）P3的结合的Akt的plecktrin同源（PH）域，以诱导Akt的构象变化，从而增强磷酸化和激活。 了解更多
  27. GSK2141795 (Uprosertib, GSK795)
    Quick View

    GSK2141795 (Uprosertib, GSK795)

    Catalog No. A15809
    Quick View
    Akt 抑制剂
    GSK2141795 (Uprosertib,GSK795)结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导。 了解更多
  28. SC 66
    Quick View

    SC 66

    Catalog No. A12081
    Quick View
    Akt 抑制剂
    SC 66是Akt的变构抑制剂，促进Akt的泛素化和失活。它在体外和体内显示抗癌活性。 了解更多
  29. TIC10
    Quick View

    TIC10

    Catalog No. A15903
    Quick View
    Akt 抑制剂?
    TIC10通过Foxo3a使Akt和ERK失活，从而诱导TRAIL，具有优越的药物特性：跨血脑屏障传递，优异的稳定性和改善的药代动力学。 了解更多
  30. Tomatidine
    Quick View

    Tomatidine

    Catalog No. A16233
    Quick View
    ERK/Akt/NF-kB 抑制剂
    Tomatidine抑制ERK，Akt的磷酸化以及NF-kB的核含量。具有抗炎特性。 了解更多
  31. Akt1 and Akt2-IN-1
    Quick View

    Akt1 and Akt2-IN-1

    Catalog No. A16285
    Quick View
    AKT 1/2 抑制剂
    Akt1 and Akt2-IN-1是Akt1（IC50 = 3.5 nM）和Akt2（IC50 = 42 nM）的变构抑制剂，具有有效且平衡的活性。 了解更多
  32. ARQ-092 (Miransertib)
    Quick View

    ARQ-092 (Miransertib)

    Catalog No. A16286
    Quick View
    AKT 抑制剂
    ARQ 092是一种口服活化，有效和选择性的AKT抑制剂，IC50值：5.0 nM（AKT1）；4.5 nM（AKT2）；16 nM（AKT3）。 了解更多
  33. Afuresertib
    Quick View

    Afuresertib

    Catalog No. A16392
    Quick View
    Akt 抑制剂
    Afuresertib是一种有效的口服生物利用性Akt抑制剂，对于Akt1，Akt2和Akt3，Ki分别为0.08 nM，2 nM和2.6 nM。 了解更多
  34. alpha-Bisabolol
    Quick View

    alpha-Bisabolol

    Catalog No. A18691
    Quick View
    alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells. 了解更多
  35. Rigosertib sodium
    Quick View

    Rigosertib sodium

    Catalog No. A21824
    Quick View
    multi-kinase inhibitor
    Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. 了解更多
  36. Palomid 529 (P529)
    Quick View

    Palomid 529 (P529)

    Catalog No. A10693
    Quick View
    AKT 抑制剂
    Palomid 529是PI3K/Akt/mTOR途径的双重TORC1/2抑制剂，在血管生成和细胞增殖中具有广泛的活性。 了解更多
  37. WYE-687
    Quick View

    WYE-687

    Catalog No. A11187
    Quick View
    mTOR 抑制剂
    WYE-687是雷帕霉素（mTOR）哺乳动物靶标的新型ATP竞争性和选择性抑制剂，IC50为7 nM；抑制mTORC1/pS6K(T389)和mTORC2/P-AKT(S473)，但不抑制P-AKT(T308)，作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。 了解更多
  38. WAY-600
    Quick View

    WAY-600

    Catalog No. A11188
    Quick View
    mTOR 抑制剂
    WAY-600是一种有效的，ATP竞争性的，选择性的mTOR抑制剂，IC50为9 nM；抑制mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473)，但不抑制P-AKT(T308)；作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。 了解更多
  39. 10-DEBC HCl
    Quick View

    10-DEBC HCl

    Catalog No. A13590
    Quick View
    AKT/PKB 抑制剂?
    10-DEBC HCl是Akt/PKB的选择性抑制剂。它抑制IGF-1刺激的磷酸化和Akt的激活（在2.5μM时完全抑制），抑制mTOR，p70 S6激酶的下游激活。 了解更多
  40. Borussertib
    Quick View

    Borussertib

    Catalog No. A13364
    Quick View
    Akt inhibitor
    Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. 了解更多
  41. Isobavachalcone
    Quick View

    Isobavachalcone

    Catalog No. A11453
    Quick View
    Akt inhibitor
    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). 了解更多
  42. OSU-T315
    Quick View

    OSU-T315

    Catalog No. A20870
    Quick View
    ILK inhibitor
    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). 了解更多
  43. Solenopsin
    Quick View

    Solenopsin

    Catalog No. A21087
    Quick View
    ATP-competitive AKT inhibitor
    Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . 了解更多
  44. YS-49
    Quick View

    YS-49

    Catalog No. A21198
    Quick View
    PI3K/Akt activator
    YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. 了解更多
  45. Ipatasertib dihydrochloride
    Quick View

    Ipatasertib dihydrochloride

    Catalog No. A21734
    Quick View
    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. 了解更多
  46. Akt-l-1
    Quick View

    Akt-l-1

    Catalog No. A12435
    Quick View
    AKT1 抑制剂
    Akt-I-1是Akt1（IC50为4.6 μM）的特异性抑制剂，不抑制AKT2或AKT3。 了解更多
  47. PF-AKT400
    Quick View

    PF-AKT400

    Catalog No. A21991
    Quick View
    Akt inhibitor
    PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). 了解更多
  48. AKT inhibitor VIII (AKTI-1/2)
    Quick View

    AKT inhibitor VIII (AKTI-1/2)

    Catalog No. A11286
    Quick View
    AKT 抑制剂
    AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物，在体外激酶测定中，该化合物有效和选择性地抑制Akt1/Akt2活性（对于Akt1，Akt2和Akt3，IC50分别为58 nM，210 nM和2.12μM）。 了解更多
  49. AKT Kinase Inhibitor
    Quick View

    AKT Kinase Inhibitor

    Catalog No. A11285
    Quick View
    Akt kinase inhibitor
    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity. 了解更多
  50. AKT-IN-1
    Quick View

    AKT-IN-1

    Catalog No. A21009
    Quick View
    AKT inhibitor
    AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. 了解更多

50 个项目

每页

设置升序顺序
联系我们
ChinaChina

Adooq 中国 (南京百鑫德诺生物科技有限公司)

免费电话: 400-025-6535

企业QQ: 400-025-6535

www.adooq.cn

sales@adooq.cn

United StatesUnited States

Adooq Bioscience

Toll Free: (866) 930-6790

Fax: +1-323-606-8156

Email: sales@adooq.com

Not your Region? View all Distributors

FILTER BY:

Filtering:

  1. 分类: PI3K / Akt / mTOR 删除该内容
清除全部

购物选项

分类
  1. Akt (40)
  2. PI3K (7)
  3. mTOR (5)
  4. PDK1 (2)
  5. DNA-PK (1)
  6. RSK (3)
  7. ATM / ATR (1)
作用机制
  1. Inhibitor (抑制剂) (47)
  2. Activator (激活剂) (2)
靶点
  1. AKT1 (8)
  2. AKT2 (7)
  3. AKT3 (5)
ADOOQ 产品质量保证
Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.

立即申请
Get Code
联系我们
查看FAQs

Adooq 公司

产品订购

技术资源

地址

© 2006-2019 AdooQ BioScience （南京百鑫德诺生物科技有限公司）. All Rights Reserved.
苏ICP备14027875号
Accept Payment
Rewards