mTOR

Catalog No.Inhibitor Name mTOR mTORC1 mTORC2 Other Targets
A10133Dactolisib
***
p110α,p110γ,p110δ
A10782Rapamycin
****
A10374Everolimus
***
A10114AZD8055
****
DNA-PK,PI3Kδ,PI3Kα
A10906Temsirolimus
*
A10726PI-103
*
p110α,p110δ,p110β
A10505KU-0063794
**
**
A10746Torkinib
**
p110δ,PDGFR,DNA-PK
A10295Ridaforolimus
****
A11461INK 128
****
PI3Kα,PI3Kγ,PI3Kδ
A10997Voxtalisib Analogue
*
PI3Kγ,PI3Kα,PI3Kδ
A11587Torin 1
***
***
**
DNA-PK,p110γ,C2α
A11035Omipalisib
****
****
p110α,p110δ,p110γ
A11056OSI-027
***
*
*
PI3Kγ,DNA-PK,PI3Kα
A11024PF-04691502
**
PI3Kδ,PI3Kα,PI3Kγ
A11023Apitolisib
*
p110α,p110δ,p110γ
A10438GSK1059615
**
PI3Kα,PI3Kβ,PI3Kδ
A11079Gedatolisib
****
PI3Kα,PI3Kγ
A10989WYE-354
***
PI3Kα,PI3Kγ
A11303Vistusertib
***
P-Akt (S473),pS6 (S235/236)
A11586Torin 2
****
ATM,ATR,DNA-PK
A11038WYE-125132
****
A11207PP121
**
PDGFR,Hck,VEGFR
A11187WYE-687
***
PI3Kα,PI3Kγ,p38α
A11169CH5132799
*
PI3Kα,PI3Kγ,PI3Kβ
A11188WAY-600
**
PI3Kα,PI3Kγ
A13328ETP-46464
****
ATR,DNA-PK,PI3Kα
A11443GDC-0349
***
PI3Kα
A12395XL388
**
**
*
CYP2C9,CYP3A4
A13078CC-223
**
cFMS,FLT4,DNA-PK
A16276Voxtalisib
*
PI3Kγ,PI3Kα,PI3Kδ
A11950Zotarolimus
***
A10389Tacrolimus
A11162BGT226
PI3Kα,PI3Kγ,PI3Kβ
A10693Palomid 529
A10210Chrysophanic Acid
EGFR
A11537QL-IX-55
A12480VS-5584
****
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A12704SF1126
PI3K
A12935PF-04979064
****
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt
A14432GNE-493
***
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A15175mTOR inhibitor (mTOR-IN-1)
***
A15508MHY1485
A16126LY3023414
PI3Kα, Akt1, DNA-PK

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PKI-587 ( Gedatolisib )

    Catalog No. A11079
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    PI3K/mTOR 抑制剂
    PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂,可抑制PI3K-α,β,γ,δ亚型和mTOR,IC50分别为0.4、6.0、5.4、6.0和1.6 nM。 了解更多

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