VEGFR

Catalog No.Inhibitor Name VEGFR1VEGFR2VEGFR3Other
A10001Sorafenib Tosylate
**
Raf-1,B-Raf,B-Raf (V599E)
A10880Sunitinib Malate
*
Kit,FLT3,PDGFRβ
A10996Cabozantinib
***
****
***
c-Met,Kit,Axl
A10080Ponatinib
****
Abl,PDGFRα,FGFR1
A10103Axitinib
****
****
****
PDGFRβ,Kit,PDGFRα
A10998Foretinib
***
****
****
Met,Tie-2,RON
A10963Vandetanib
**
*
A10137Nintedanib
**
***
***
LCK,FLT3,FGFR2
A10250Regorafenib
***
****
*
RET,Raf-1,Kit
A11518Pazopanib HCl
***
**
*
FGFR,PDGFR,c-Kit
A10185Cediranib
***
****
****
c-Kit,PDGFRβ,FGFR1
A10703PD173074
*
FGFR1,c-Src
A11411Dovitinib
***
***
***
FLT3,c-Kit,FGFR1
A10025Linifanib
****
****
*
CSF-1R,FLT3,Kit
A10967Vatalanib 2HCl
*
**
*
PDGFRβ,c-Kit,c-Fms
A10773RAF265
**
B-Raf
A10101Tivozanib
**
***
**
EphB2,PDGFRα,PDGFRβ
A10608Motesanib Diphosphate
****
****
***
Kit,RET,PDGFR
A10340Lenvatinib
**
****
***
PDGFRβ,FGFR1,PDGFRα
A10953Orantinib
*
PDGFRβ,FGFR1
A10254Brivanib
*
**
FGFR1
A10587MGCD-265
****
****
****
Met,RON,Tie-2
A10043AEE788
*
*
*
EGFR,HER2/ErbB2,c-Abl
A10352ENMD-2076
*
**
FLT3,RET,Aurora A
A10679OSI-930
***
***
CSF-1R,LCK,C-Raf
A10248CYC116
**
Aurora A,Aurora B,FLT3
A10502Ki8751
****
c-Kit,PDGFRα,FGFR2
A10903Telatinib
***
****
c-Kit,PDGFRα
A11518Pazopanib
***
**
*
FGFR,PDGFR,c-Kit
A10504KRN 633
*
*
*
PDGFRα,c-Kit,BTK
A13377SAR131675
**
A10198Dovitinib Dilactic Acid
***
***
***
FLT3,c-Kit,FGFR1
A11407Apatinib
****
RET,c-Kit,c-Src
A10154BMS-794833
**
Met
A10162Brivanib Alaninate
*
**
FGFR1
A11396Golvatinib
**
c-Met
A11954ZM 323881 HCl
****
A11955ZM 306416
*
Src,Abl
A16342BFH772
****
A11558SU5402
**
FGFR1,PDGFRβ
A12437Semaxanib
*
A11244LY2874455
***
FGFR2,FGFR1,FGFR4
A13234SKLB1002
**
A14156AZD2932
***
PDGFRβ,Flt3,c-Kit
A10893Taxifolin (Dihydroquercetin)
A11772CP-547632
***
FGFR
A12693BAW2881 (NVP-BAW2881)
*
***
*
C-Raf-1,B-RAFV599E,c-Abl
A13465SKLB610
*
PDGFR, FGFR2
A13819TG 100801
****
***
FGFR1, Fyn, Src
A13820TG 100572
****
***
FGFR1, Fyn, Src
A14387ltiratinib (DCC2701)
***
MET, TIE2, TRK
A15073E-3810
***
**
***
FGFR-1, FGFR-2
A15287ZM323881
****
A15792BMS-817378
***
c-Met

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. TAK-593

    Catalog No. A13555
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    VEGFR/PDGFR 抑制剂
    TAK-5933是一种口服制剂,其中含有血管内皮生长因子受体(VEGFR)和血小板衍生生长因子受体(PDGFR)的小分子受体酪氨酸激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  2. Nintedanib esylate

    Catalog No. A16197
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    RTK 抑制剂
    Nintedanib esylate是多种受体酪氨酸激酶(RTK)和非受体酪氨酸激酶(nRTK)的有效抑制剂。 了解更多
  3. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR 抑制剂
    Pazopanib (GW-786034)是VEGFR-1,VEGFR-2,VEGFR-3,PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂,可阻止肿瘤生长并抑制血管生成。 了解更多
  4. Ki8751

    Catalog No. A10502
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    VEGFR-2 抑制剂
    ki8751是一种细胞可渗透的喹啉氧基苯基脲化合物,在基于细胞和无细胞的检测中起Flk-1 (VEGFR-2)选择性抑制剂的作用。 了解更多

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